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Recent progress in studies of pituitary tumor pathogenesis

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Abstract

The mechanisms of tumorigenesis of the human pituitary have been elucidated to a limited extent. Classically, pituitary tumor formation was shown to be induced by thyroidectomy and estrogen administration. Molecular biological and immunohistochemical studies have revealed several aspects of pituitary tumorigenesis. Trans-lineage cell differentiation has been shown to be induced by the aberrant expression of transcription factors and co-factors, such as Pit-1, Prop-1, and estrogen receptor. Defects or overexpression of cell cycle regulators, such as CDK inhibitors, PTTG, and GADD45γ, result in the abnormal proliferation of pituitary cells. Recently, epigenetic regulation has been suggested to be related to pituitary tumor formation. This article presents a review and update of recent progress in studies of the development and differentiation of pituitary tumors.

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Authors and Affiliations

  1. Department of Pathology, Tokai University School of Medicine, 259-1193, Boseidai, Isehara, Kanagawa, Japan

    Takeo Minematsu, Shunsuke Miyai, Hanako Kajiya, Susumu Takekoshi & Robert Y. Osamura MD

  2. Department of Neurosurgery, Nippon Medical School Bunkyo-ku, 133-8603, Tokyo, Japan

    Masanori Suzuki, Naoko Sanno & Akira Teramoto

Authors
  1. Takeo Minematsu
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  2. Shunsuke Miyai
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  3. Hanako Kajiya
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  4. Masanori Suzuki
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  5. Naoko Sanno
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  6. Susumu Takekoshi
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  7. Akira Teramoto
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  8. Robert Y. Osamura MD
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Correspondence to Robert Y. Osamura MD.

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Minematsu, T., Miyai, S., Kajiya, H. et al. Recent progress in studies of pituitary tumor pathogenesis. Endocr 28, 37–41 (2005). https://doi.org/10.1385/ENDO:28:1:037

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  • DOI: https://doi.org/10.1385/ENDO:28:1:037

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