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Melatonin and parkinson’s disease

Endocrine volume 27, pages 169–178 (2005)Cite this article

Abstract

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnosis or effective treatments extremely difficult. Only symptomatic therapies have been used, including levodopa (l-dopa), to restore dopamine content; however, the use of l-dopa leads to some long-term pro-oxidant damage. In addition to a few specific mutations, oxidative stress and generation of free radicals from both mitochondrial impairment and dopamine metabolism are considered to play critical roles in PD etiology. Thus, the use of antioxidants as an important co-treatment with traditional therapies for PD has been suggested. Melatonin, or N-acetyl-5-methoxy-tryptamine, an indole mainly produced in the pineal gland, has been shown to have potent endogenous antioxidant actions. Because neurodegenerative disorders are mainly caused by oxidative damage, melatonin has been tested successfully in both in vivo and in vitro models of PD. The present review provides an up-to-date account of the findings and mechanisms involved in neuroprotection of melatonin in PD.

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References

  1. de Rijk, M. C., Launer, L. J., Berger, K., et al. (2000). Neurology 54, S21-S23.

    PubMed  Google Scholar 

  2. Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998). Proc. Natl. Acad. Sci. USA 95, 6469–6473.

    PubMed  CAS  Article  Google Scholar 

  3. Huang, Y., Cheung, L., Rowe, D., and Halliday, G. (2004). Brain Res. Brain Res. Rev. 46, 44–70.

    PubMed  CAS  Article  Google Scholar 

  4. Vila, M. and Przedborski, S. (2004). Nat. Med. 10(Suppl.), S58-S62.

    PubMed  Article  CAS  Google Scholar 

  5. Halliwell, B. and Gutteridge, J. M. C. (eds.) (1999). Free radicals in biology and medicine. Oxford University Press: Oxford, UK.

    Google Scholar 

  6. Halliwell, B. and Gutteridge, J. M. (1984). Lancet 1, 1396–1397.

    PubMed  CAS  Article  Google Scholar 

  7. Halliwell, B. and Whiteman, M. (2004). Br. J. Pharmacol. 142, 231–255.

    PubMed  CAS  Article  Google Scholar 

  8. Dexter, D. T., Sian, J., Jenner, P., and Marsden, C. D. (1993). Adv. Neurol. 60, 273–281.

    PubMed  CAS  Google Scholar 

  9. Youdim, M. B., Stephenson, G., and Ben Shachar, D. (2004). Ann. NY Acad. Sci. 1012, 306–325.

    PubMed  CAS  Article  Google Scholar 

  10. Sian, J., Dexter, D. T., Lees, A. J., et al. (1994). Ann. Neurol. 36, 348–355.

    PubMed  CAS  Article  Google Scholar 

  11. Dexter, D. T., Carter, C. J., Wells, F. R., et al. (1989). J. Neurochem. 52, 381–389.

    PubMed  CAS  Article  Google Scholar 

  12. Sanchez-Ramos, J., Overvik, E., and Ames, A. B. (1994). Neurodegeneration 3, 197–204.

    Google Scholar 

  13. Schapira, A. H. (1998). Biochim. Biophys. Acta 1366, 225–233.

    PubMed  CAS  Article  Google Scholar 

  14. Beal, M. F. (2003). Ann. NY Acad. Sci. 991, 120–131.

    PubMed  CAS  Article  Google Scholar 

  15. Beal, M. F. (1998). Ann. Neurol. 44, S110-S114.

    PubMed  CAS  Article  Google Scholar 

  16. Graham, D. G. (1978). Mol. Pharmacol. 14, 633–643.

    PubMed  CAS  Google Scholar 

  17. Spina, M. B. and Cohen, G. (1988). J. Pharmacol. Exp. Ther. 247, 502–507.

    PubMed  CAS  Google Scholar 

  18. Zecca, L., Youdim, M. B., Riederer, P., Connor, J. R., and Crichton, R. R. (2004). Nat. Rev. Neurosci. 5, 863–873.

    PubMed  CAS  Article  Google Scholar 

  19. Tieu, K., Ischiropoulos, H., and Przedborski, S. (2003). IUBMB Life 55, 329–335.

    PubMed  CAS  Google Scholar 

  20. Carreras, M. C., Franco, M. C., Peralta, J. G., and Poderoso, J. J. (2004). Mol. Aspects Med. 25, 125–139.

    PubMed  CAS  Article  Google Scholar 

  21. Schulz, J. B., Matthews, R. T., Muqit, M. M., Browne, S. E., and Beal, M. F. (1995). J. Neurochem. 64, 936–939.

    PubMed  CAS  Article  Google Scholar 

  22. Przedborski, S., Jackson-Lewis, V., Yokoyama, R., Shibata, T., Dawson, V. L., and Dawson, T. M. (1996). Proc. Natl. Acad. Sci. USA 93, 4565–4571.

    PubMed  CAS  Article  Google Scholar 

  23. Wu, D. C., Jackson-Lewis, V., Vila, M., et al. (2002). J. Neurosci. 22, 1763–1771.

    PubMed  CAS  Google Scholar 

  24. Olanow, C. W., Agid, Y., Mizuno, Y., et al. (2004). Mov. Disord. 19, 997–1005.

    PubMed  Article  Google Scholar 

  25. Dauer, W. and Przedborski, S. (2003). Neuron 39, 889–909.

    PubMed  CAS  Article  Google Scholar 

  26. Meissner, W., Hill, M. P., Tison, F., Gross, C. E., and Bezard, E. (2004). Trends Pharmacol. Sci. 25, 249–253.

    PubMed  CAS  Article  Google Scholar 

  27. Stocchi, F. and Olanow, C. W. (2003). Ann. Neurol. 53(Suppl. 3), S87-S97.

    PubMed  CAS  Article  Google Scholar 

  28. Langston, J. W., Ballard, P., Tetrud, J. W., and Irwin, I. (1983). Science 219, 979–980.

    PubMed  CAS  Article  Google Scholar 

  29. Liu, Y., Roghani, A., and Edwards, R. H. (1992). Proc. Natl. Acad. Sci. USA 89, 9074–9078.

    PubMed  CAS  Article  Google Scholar 

  30. Nicklas, W. J., Vyas, I., and Heikkila, R. E. (1985). Life Sci. 36, 2503–2508.

    PubMed  CAS  Article  Google Scholar 

  31. Ungerstedt, U., Ljungberg, T., and Steg, G. (1974). Adv. Neurol. 5, 421–426.

    PubMed  CAS  Google Scholar 

  32. Cohen, G. and Kesler, N. (1999). J. Neurochem. 73, 2310–2315.

    PubMed  CAS  Article  Google Scholar 

  33. Day, B. J., Patel, M., Calavetta, L., Chang, L. Y., and Stamler, J. S. (1999). Proc. Natl. Acad. Sci. USA 96, 12760–12765.

    PubMed  CAS  Article  Google Scholar 

  34. Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V., and Greenamyre, J. T. (2000). Nat. Neurosci. 3, 1301–1306.

    PubMed  CAS  Article  Google Scholar 

  35. Sherer, T. B., Betarbet, R., Testa, C. M., et al. (2003). J. Neurosci. 23, 10756–10764.

    PubMed  CAS  Google Scholar 

  36. Good, P. F., Hsu, A., Werner, P., Perl, D. P., and Olanow, C. W. (1998). J. Neuropathol. Exp. Neurol. 57, 338–342.

    PubMed  CAS  Google Scholar 

  37. Dennis, J. and Bennett, J. P. Jr. (2003). J. Neurosci. Res. 72, 89–97.

    PubMed  CAS  Article  Google Scholar 

  38. Schapira, A. H., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., and Marsden, C. D. (1990). J. Neurochem. 54, 823–827.

    PubMed  CAS  Article  Google Scholar 

  39. Gu, M., Cooper, J. M., Taanman, J. W., and Schapira, A. H. (1998). Ann. Neurol. 44, 177–186.

    PubMed  CAS  Article  Google Scholar 

  40. Swerdlow, R. H., Parks, J. K., Miller, S. W., et al. (1996). Ann. Neurol. 40, 663–671.

    PubMed  CAS  Article  Google Scholar 

  41. Sheehan, J. P., Swerdlow, R. H., Parker, W. D., Miller, S. W., Davis, R. E., and Tuttle, J. B. (1997). J. Neurochem. 68, 1221–1233.

    PubMed  CAS  Article  Google Scholar 

  42. Vila, M. and Przedborski, S. (2003). Nat. Rev. Neurosci. 4, 365–375.

    PubMed  CAS  Article  Google Scholar 

  43. Hartmann, A., Hunot, S., Michel, P. P., et al. (2000). Proc. Natl. Acad. Sci. USA 97, 2875–2880.

    PubMed  CAS  Article  Google Scholar 

  44. Yang, L., Matthews, R. T., Schulz, J. B., et al. (1998). J. Neurosci. 18, 8145–8152.

    PubMed  CAS  Google Scholar 

  45. Tatton, N. A. and Kish, S. J. (1997). Neuroscience 77, 1037–1048.

    PubMed  CAS  Article  Google Scholar 

  46. Kreutzberg, G. W. (1996). Trends Neurosci. 19, 312–318.

    PubMed  CAS  Article  Google Scholar 

  47. Liu, B., Gao, H. M., and Hong, J. S. (2003). Environ. Health Perspect. 111, 1065–1073.

    PubMed  CAS  Google Scholar 

  48. Lindsay, R. M., Wiegand, S. J., Altar, C. A., and DiStefano, P. S. (1994). Trends Neurosci. 17, 182–190.

    PubMed  CAS  Article  Google Scholar 

  49. Qin, L., Liu, Y., Cooper, C., Liu, B., Wilson, B., and Hong, J. S. (2002). J. Neurochem. 83, 973–983.

    PubMed  CAS  Article  Google Scholar 

  50. Kim, W. G., Mohney, R. P., Wilson, B., Jeohn, G. H., Liu, B., and Hong, J. S. (2000). J. Neurosci. 20, 6309–6316.

    PubMed  CAS  Google Scholar 

  51. Hunt, S., Boissiere, F., Faucheux, B., et al. (1996). Neuroscience 72, 355–363.

    Article  Google Scholar 

  52. Hunot, S., Dugas, N., Faucheux, B., et al. (1999). J. Neurosci. 19, 3440–3447.

    PubMed  CAS  Google Scholar 

  53. Teismann, P., Vila, M., Choi, D. K., et al. (2003). Ann. NY Acad. Sci. 991, 272–277.

    PubMed  CAS  Article  Google Scholar 

  54. Teismann, P., Tieu, K., Choi, D. K., et al. (2003). Proc. Natl. Acad. Sci. USA 100, 5473–5478.

    PubMed  CAS  Article  Google Scholar 

  55. Gao, H. M., Jiang, J., Wilson, B., Zhang, W., Hong, J. S., and Liu, B. (2002). J. Neurochem. 81, 1285–1297.

    PubMed  CAS  Article  Google Scholar 

  56. Reiter, R. J. (1991). Mol. Cell Endocrinol. 79, C153-C158.

    PubMed  CAS  Article  Google Scholar 

  57. Gern, W. A. and Ralph, C. L. (1979). Science 204, 183–184.

    PubMed  CAS  Article  Google Scholar 

  58. Menendez-Pelaez, A., Reiter, R. J., Howes, K. A., et al. (1988). Endocr. Res. 14, 121–130.

    PubMed  CAS  Article  Google Scholar 

  59. Tan, D. X., Manchester, L. C., Reiter, R. J., et al. (1999). Biochim. Biophys. Acta 1472, 206–214.

    PubMed  CAS  Google Scholar 

  60. Hardeland, R. and Poeggeler, B. (2003). J. Pineal Res. 34, 233–241.

    PubMed  CAS  Article  Google Scholar 

  61. Reiter, R. J. (1991). Endocr. Rev. 12, 151–180.

    PubMed  CAS  Article  Google Scholar 

  62. Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., and Ruhoff, M. S. (1999). Adv. Exp. Med. Biol. 460, 337–343.

    PubMed  CAS  Article  Google Scholar 

  63. Fraschini, F. and Reiter, R. J. (eds.) (1991). Role of melatonin and pineal peptides in neuroimmunomodulation. Plenum Press: New York.

    Google Scholar 

  64. Guerrero, J. M. and Reiter, R. J. (2002). Curr. Top. Med. Chem. 2, 167–179.

    PubMed  CAS  Article  Google Scholar 

  65. Tan, D. X., Chen, L. D., Poeggeler, B., Manchester, L. C., and Reiter, R. J. (1993). Endocr. J. 1, 57–60.

    Google Scholar 

  66. Tan, D. X., Manchester, L. C., Reiter, R. J., et al. (1998). Biochem. Biophys. Res. Commun. 253, 614–620.

    PubMed  CAS  Article  Google Scholar 

  67. Tan, D. X., Manchester, L. C., Burkhardt, S., et al. (2001). FASEB J. 15, 2294–2296.

    PubMed  CAS  Google Scholar 

  68. Barlow-Walden, L. R., Reiter, R. J., Abe, M., et al. (1995). Neurochem. Int. 26, 497–502.

    PubMed  CAS  Article  Google Scholar 

  69. Mayo, J. C., Sainz, R. M., Antoli, I., Herrera, F., Martin, V., and Rodriguez, C. (2002). Cell Mol. Life Sci. 59, 1706–1713.

    PubMed  CAS  Article  Google Scholar 

  70. Antolin, I., Rodriguez, C., Sainz, R. M., et al. (1996). FASEB J. 10, 882–890.

    PubMed  CAS  Google Scholar 

  71. Sofic, E., Rimpapa, Z., Kundurovic, Z., et al. (2005). J. Neural Transm. 112, 349–358.

    PubMed  CAS  Article  Google Scholar 

  72. Tan, D. X., Reiter, R. J., Manchester, L. C., et al. (2002). Curr. Top. Med. Chem. 2, 181–197.

    PubMed  CAS  Article  Google Scholar 

  73. Reiter, R. J., Tan, D. X., and Pappolla, M. A. (2004). Ann. NY Acad. Sci. 1035, 179–196.

    PubMed  CAS  Article  Google Scholar 

  74. Sewerynek, E., Melchiorri, D., Ortiz, G. G., Poeggeler, B., and Reiter, R. J. (1995). J. Pineal Res. 19, 51–56.

    PubMed  CAS  Article  Google Scholar 

  75. Mohanan, P. V. and Yamamoto, H. A. (2002). Toxicol. Lett. 129, 99–105.

    PubMed  CAS  Article  Google Scholar 

  76. Lopez-Burillo, S., Tan, D. X., Mayo, J. C., Sainz, R. M., Manchester, L. C., and Reiter, R. J. (2003). J. Pineal Res. 34, 269–277.

    PubMed  CAS  Article  Google Scholar 

  77. Mayo, J. C., Tan, D. X., Sainz, R. M., Natarajan, M., Lopez-Burillo, S., and Reiter, R. J. (2003). Biochim. Biophys. Acta 1620, 139–150.

    PubMed  CAS  Google Scholar 

  78. Stefulj, J., Hortner, M., Ghosh, M., et al. (2001). J. Pineal Res. 30, 243–247.

    PubMed  CAS  Article  Google Scholar 

  79. Tan, D. X., Manchester, L. C., Hardeland, R., et al. (2003). J. Pineal Res. 34, 75–78.

    PubMed  CAS  Article  Google Scholar 

  80. Borlongan, C. V., Yamamoto, M., Takei, N., et al. (2000). FASEB J. 14, 1307–1317.

    PubMed  CAS  Article  Google Scholar 

  81. Cheung, R. T. (2003). J. Pineal Res. 34, 153–160.

    PubMed  CAS  Article  Google Scholar 

  82. Reiter, R. J., Tan, D. X., Leon, J., Kilic, U., and Kilic, E. (2005). Exp. Biol. Med. (Maywood.) 230, 104–117.

    CAS  Google Scholar 

  83. Antolin, I., Mayo, J. C., Sainz, R. M., et al. (2002). Brain Res. 943, 163–173.

    PubMed  CAS  Article  Google Scholar 

  84. Pappolla, M. A., Simovich, M. J., Bryant-Thomas, T., et al. (2002). J. Pineal Res. 32, 135–142.

    PubMed  CAS  Article  Google Scholar 

  85. Reiter, R. J., Cabrera, J., Sainz, R. M., Mayo, J. C., Manchester, L. C., and Tan, D. X. (1999). Ann. NY Acad. Sci. 890, 471–485.

    PubMed  CAS  Article  Google Scholar 

  86. Sandyk, R. (1990). Int. J. Neurosci. 50, 37–53.

    PubMed  CAS  Google Scholar 

  87. Miller, J. W., Selhub, J., and Joseph, J. A. (1996). Free Radic. Biol. Med. 21, 241–249.

    PubMed  CAS  Article  Google Scholar 

  88. Khaldy, H., Escames, G., Leon, J., Vives, F., Luna, J. D., and Acuna-Castroviejo, D. (2000). J. Pineal Res. 29, 100–107.

    PubMed  CAS  Article  Google Scholar 

  89. Acuna-Castroviejo, D., Coto-Montes, A., Gaia, M. M., Ortiz, G. G., and Reiter, R. J. (1997). Life Sci. 60, L23-L29.

    Google Scholar 

  90. Jin, B. K., Shin, D. Y., Jeong, M. Y., et al. (1998). Neurosci. Lett. 245, 61–64.

    PubMed  CAS  Article  Google Scholar 

  91. Kim, Y. S., Joo, W. S., Jin, B. K., Cho, Y. H., Baik, H. H., and Park, C. W. (1998). Neuroreport 9, 2387–2390.

    PubMed  CAS  Article  Google Scholar 

  92. Joo, W. S., Jin, B. K., Park, C. W., Maeng, S. H., and Kim, Y. S. (1998). Neuroreport 9, 4123–4126.

    PubMed  CAS  Article  Google Scholar 

  93. Ortiz, G. G., Crespo-Lopez, M. E., Moran-Moguel, C., Garcia, J. J., Reiter, R. J., and Acuna-Castroviejo, D. (2001). Neuroendocrinol. Lett. 22, 101–108.

    PubMed  CAS  Google Scholar 

  94. Dabbeni-Sala, F., Di Santo, S., Franceschini, D., Skaper, S. D., and Giusti, P. (2001). FASEB J. 15, 164–170.

    PubMed  CAS  Article  Google Scholar 

  95. Leon, J., Acuna-Castroviejo, D., Escames, G., Tan, D. X., and Reiter, R. J. (2005). J. Pineal Res. 38, 1–9.

    PubMed  CAS  Article  Google Scholar 

  96. Khaldy, H., Escames, G., Leon, J., Bikjdaouene, L., and Acuna-Castroviejo, D. (2003). Neurobiol. Aging 24, 491–500.

    PubMed  CAS  Article  Google Scholar 

  97. Chen, S. T., Chuang, J. I., Hong, M. H., and Li, E. I. (2002). J. Pineal Res. 32, 262–269.

    PubMed  CAS  Article  Google Scholar 

  98. Thomas, B. and Mohanakumar, K. P. (2004). J. Pineal Res. 36, 25–32.

    PubMed  CAS  Article  Google Scholar 

  99. Coulom, H. and Birman, S. (2004). J. Neurosci. 24, 10993–10998.

    PubMed  CAS  Article  Google Scholar 

  100. Iacovitti, L., Stull, N. D., and Johnston, K. (1997). Brain Res. 768, 317–326.

    PubMed  CAS  Article  Google Scholar 

  101. Iacovitti, L., Stull, N. D., and Mishizen, A. (1999). Brain Res. 816, 276–285.

    PubMed  CAS  Article  Google Scholar 

  102. Walkinshaw, G. and Waters, C. M. (1994). Neuroscience 63, 975–987.

    PubMed  CAS  Article  Google Scholar 

  103. Andersen, J. K. (2001). Bioessays 23, 640–646.

    PubMed  CAS  Article  Google Scholar 

  104. Mayo, J. C., Sainz, R. M., Uria, H., Antolin, I., Esteban, M. M., and Rodriguez, C. (1998). J. Pineal Res. 24, 179–192.

    PubMed  CAS  Article  Google Scholar 

  105. Mayo, J. C., Sainz, R. M., Antolin, I., and Rodriguez, C. (1999). Brain Res. 818, 221–227.

    PubMed  CAS  Article  Google Scholar 

  106. Pappolla, M. A., Sos, M., Omar, R. A., et al. (1997). J. Neurosci. 17, 1683–1690.

    PubMed  CAS  Google Scholar 

  107. Feng, Z. and Zhang, J. T. (2004). J. Pineal Res. 37, 257–266.

    PubMed  CAS  Article  Google Scholar 

  108. Cazevieille, C., Safa, R., and Osborne, N. N. (1997). Brain Res. 768, 120–124.

    PubMed  CAS  Article  Google Scholar 

  109. Herrera, F., Sainz, R. M., Mayo, J. C., Martin, V., Antolin, I., and Rodriguez, C. (2001). J. Pineal Res. 31, 356–362.

    PubMed  CAS  Article  Google Scholar 

  110. Jou, M. J., Peng, T. I., Reiter, R. J., Jou, S. B., Wu, H. Y., and Wen, S. T. (2004). J. Pineal Res. 37, 55–70.

    PubMed  CAS  Article  Google Scholar 

  111. Imam, S. Z., el Yazal, J., Newport, G. D., et al. (2001). Ann. NY Acad. Sci. 939, 366–380.

    PubMed  CAS  Article  Google Scholar 

  112. Lezoualc’h, F., Sparapani, M., and Behl, C. (1998). J. Pineal Res. 24, 168–178.

    PubMed  CAS  Article  Google Scholar 

  113. Chetsawang, B., Govitrapong, P., and Ebadi, M. (2004). Neurosci. Lett. 371, 205–208.

    PubMed  CAS  Article  Google Scholar 

  114. Martin, V., Sainz, R. M., Antolin, I., Mayo, J. C., Herrera, F., and Rodriguez, C. (2002). J. Pineal Res. 33, 204–212.

    PubMed  CAS  Article  Google Scholar 

  115. Mayo, J. C., Tan, D. X., Sainz, R. M., Lopez-Burillo, S., and Reiter, R. J. (2003). Free Radic. Res. 37, 543–553.

    PubMed  CAS  Article  Google Scholar 

  116. Armstrong, K. J. and Niles, L. P. (2002). Neuroreport 13, 473–475.

    PubMed  CAS  Article  Google Scholar 

  117. Chung, S. Y. and Han, S. H. (2003). J. Pineal Res. 34, 95–102.

    PubMed  CAS  Article  Google Scholar 

  118. Martin, M., Macias, M., Leon, J., Escames, G., Khaldy, H., and Acuna-Castroviejo, D. (2002). Int. J. Biochem. Cell Biol. 34, 348–357.

    PubMed  CAS  Article  Google Scholar 

  119. Martin, M., Macias, M., Escames, G., Leon, J., and Acuna-Castroviejo, D. (2000). FASEB J. 14, 1677–1679.

    PubMed  CAS  Google Scholar 

  120. Acuna, C. D., Escames, G., Carazo, A., Leon, J., Khaldy, H., and Reiter, R. J. (2002). Curr. Top. Med. Chem. 2, 133–151.

    PubMed  Article  Google Scholar 

  121. Boeve, B. F., Silber, M. H., and Ferman, T. J. (2003). Sleep Med. 4, 281–284.

    PubMed  Article  Google Scholar 

  122. Boeve, B. F., Silber, M. H., and Ferman, T. J. (2004). J. Geriatr. Psychiatry Neurol. 17, 146–157.

    PubMed  Article  Google Scholar 

  123. Bruguerolle, B. and Simon, N. (2002). Clin. Neuropharmacol. 25, 194–201.

    PubMed  Article  Google Scholar 

  124. Sandyk, R. (1990). Int. J. Neurosci. 51, 73–77.

    PubMed  CAS  Google Scholar 

  125. Bordet, R., Devos, D., Brique, S., et al. (2003). Clin. Neuropharmacol. 26, 65–72.

    PubMed  CAS  Article  Google Scholar 

  126. Stull, N. D., Polan, D. P., and Iacovitti, L. (2002). Brain Res. 931, 181–185.

    PubMed  CAS  Article  Google Scholar 

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Authors and Affiliations

  1. Departamento de Morfología y Biología Celular, School of Medicine, University of Oviedo, Oviedo, Spain

    Juan C. Mayo, Rosa M. Sainz, Isaac Antolín & Carmen Rodríguez

  2. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78229-3900, San Antonio, TX, USA

    Dun-Xian Tan & Russel J. Reiter

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  1. Juan C. Mayo
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Mayo, J.C., Sainz, R.M., Tan, DX. et al. Melatonin and parkinson’s disease. Endocr 27, 169–178 (2005). https://doi.org/10.1385/ENDO:27:2:169

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Key Words

  • Melatonin
  • Parkinson’s disease
  • antioxidant
  • oxidative damage
  • dopaminergic neurons
  • neurodegeneration