, Volume 27, Issue 2, pp 169–178 | Cite as

Melatonin and parkinson’s disease

  • Juan C. Mayo
  • Rosa M. Sainz
  • Dun-Xian Tan
  • Isaac Antolín
  • Carmen Rodríguez
  • Russel J. ReiterEmail author


Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is characterized by a progressive loss of dopamine in the substantia nigra and striatum. However, over 70% of dopaminergic neuronal death occurs before the first symptoms appear, which makes either early diagnosis or effective treatments extremely difficult. Only symptomatic therapies have been used, including levodopa (l-dopa), to restore dopamine content; however, the use of l-dopa leads to some long-term pro-oxidant damage. In addition to a few specific mutations, oxidative stress and generation of free radicals from both mitochondrial impairment and dopamine metabolism are considered to play critical roles in PD etiology. Thus, the use of antioxidants as an important co-treatment with traditional therapies for PD has been suggested. Melatonin, or N-acetyl-5-methoxy-tryptamine, an indole mainly produced in the pineal gland, has been shown to have potent endogenous antioxidant actions. Because neurodegenerative disorders are mainly caused by oxidative damage, melatonin has been tested successfully in both in vivo and in vitro models of PD. The present review provides an up-to-date account of the findings and mechanisms involved in neuroprotection of melatonin in PD.

Key Words

Melatonin Parkinson’s disease antioxidant oxidative damage dopaminergic neurons neurodegeneration 


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  1. 1.
    de Rijk, M. C., Launer, L. J., Berger, K., et al. (2000). Neurology 54, S21-S23.PubMedGoogle Scholar
  2. 2.
    Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998). Proc. Natl. Acad. Sci. USA 95, 6469–6473.PubMedCrossRefGoogle Scholar
  3. 3.
    Huang, Y., Cheung, L., Rowe, D., and Halliday, G. (2004). Brain Res. Brain Res. Rev. 46, 44–70.PubMedCrossRefGoogle Scholar
  4. 4.
    Vila, M. and Przedborski, S. (2004). Nat. Med. 10(Suppl.), S58-S62.PubMedCrossRefGoogle Scholar
  5. 5.
    Halliwell, B. and Gutteridge, J. M. C. (eds.) (1999). Free radicals in biology and medicine. Oxford University Press: Oxford, UK.Google Scholar
  6. 6.
    Halliwell, B. and Gutteridge, J. M. (1984). Lancet 1, 1396–1397.PubMedCrossRefGoogle Scholar
  7. 7.
    Halliwell, B. and Whiteman, M. (2004). Br. J. Pharmacol. 142, 231–255.PubMedCrossRefGoogle Scholar
  8. 8.
    Dexter, D. T., Sian, J., Jenner, P., and Marsden, C. D. (1993). Adv. Neurol. 60, 273–281.PubMedGoogle Scholar
  9. 9.
    Youdim, M. B., Stephenson, G., and Ben Shachar, D. (2004). Ann. NY Acad. Sci. 1012, 306–325.PubMedCrossRefGoogle Scholar
  10. 10.
    Sian, J., Dexter, D. T., Lees, A. J., et al. (1994). Ann. Neurol. 36, 348–355.PubMedCrossRefGoogle Scholar
  11. 11.
    Dexter, D. T., Carter, C. J., Wells, F. R., et al. (1989). J. Neurochem. 52, 381–389.PubMedCrossRefGoogle Scholar
  12. 12.
    Sanchez-Ramos, J., Overvik, E., and Ames, A. B. (1994). Neurodegeneration 3, 197–204.Google Scholar
  13. 13.
    Schapira, A. H. (1998). Biochim. Biophys. Acta 1366, 225–233.PubMedCrossRefGoogle Scholar
  14. 14.
    Beal, M. F. (2003). Ann. NY Acad. Sci. 991, 120–131.PubMedCrossRefGoogle Scholar
  15. 15.
    Beal, M. F. (1998). Ann. Neurol. 44, S110-S114.PubMedCrossRefGoogle Scholar
  16. 16.
    Graham, D. G. (1978). Mol. Pharmacol. 14, 633–643.PubMedGoogle Scholar
  17. 17.
    Spina, M. B. and Cohen, G. (1988). J. Pharmacol. Exp. Ther. 247, 502–507.PubMedGoogle Scholar
  18. 18.
    Zecca, L., Youdim, M. B., Riederer, P., Connor, J. R., and Crichton, R. R. (2004). Nat. Rev. Neurosci. 5, 863–873.PubMedCrossRefGoogle Scholar
  19. 19.
    Tieu, K., Ischiropoulos, H., and Przedborski, S. (2003). IUBMB Life 55, 329–335.PubMedGoogle Scholar
  20. 20.
    Carreras, M. C., Franco, M. C., Peralta, J. G., and Poderoso, J. J. (2004). Mol. Aspects Med. 25, 125–139.PubMedCrossRefGoogle Scholar
  21. 21.
    Schulz, J. B., Matthews, R. T., Muqit, M. M., Browne, S. E., and Beal, M. F. (1995). J. Neurochem. 64, 936–939.PubMedCrossRefGoogle Scholar
  22. 22.
    Przedborski, S., Jackson-Lewis, V., Yokoyama, R., Shibata, T., Dawson, V. L., and Dawson, T. M. (1996). Proc. Natl. Acad. Sci. USA 93, 4565–4571.PubMedCrossRefGoogle Scholar
  23. 23.
    Wu, D. C., Jackson-Lewis, V., Vila, M., et al. (2002). J. Neurosci. 22, 1763–1771.PubMedGoogle Scholar
  24. 24.
    Olanow, C. W., Agid, Y., Mizuno, Y., et al. (2004). Mov. Disord. 19, 997–1005.PubMedCrossRefGoogle Scholar
  25. 25.
    Dauer, W. and Przedborski, S. (2003). Neuron 39, 889–909.PubMedCrossRefGoogle Scholar
  26. 26.
    Meissner, W., Hill, M. P., Tison, F., Gross, C. E., and Bezard, E. (2004). Trends Pharmacol. Sci. 25, 249–253.PubMedCrossRefGoogle Scholar
  27. 27.
    Stocchi, F. and Olanow, C. W. (2003). Ann. Neurol. 53(Suppl. 3), S87-S97.PubMedCrossRefGoogle Scholar
  28. 28.
    Langston, J. W., Ballard, P., Tetrud, J. W., and Irwin, I. (1983). Science 219, 979–980.PubMedCrossRefGoogle Scholar
  29. 29.
    Liu, Y., Roghani, A., and Edwards, R. H. (1992). Proc. Natl. Acad. Sci. USA 89, 9074–9078.PubMedCrossRefGoogle Scholar
  30. 30.
    Nicklas, W. J., Vyas, I., and Heikkila, R. E. (1985). Life Sci. 36, 2503–2508.PubMedCrossRefGoogle Scholar
  31. 31.
    Ungerstedt, U., Ljungberg, T., and Steg, G. (1974). Adv. Neurol. 5, 421–426.PubMedGoogle Scholar
  32. 32.
    Cohen, G. and Kesler, N. (1999). J. Neurochem. 73, 2310–2315.PubMedCrossRefGoogle Scholar
  33. 33.
    Day, B. J., Patel, M., Calavetta, L., Chang, L. Y., and Stamler, J. S. (1999). Proc. Natl. Acad. Sci. USA 96, 12760–12765.PubMedCrossRefGoogle Scholar
  34. 34.
    Betarbet, R., Sherer, T. B., MacKenzie, G., Garcia-Osuna, M., Panov, A. V., and Greenamyre, J. T. (2000). Nat. Neurosci. 3, 1301–1306.PubMedCrossRefGoogle Scholar
  35. 35.
    Sherer, T. B., Betarbet, R., Testa, C. M., et al. (2003). J. Neurosci. 23, 10756–10764.PubMedGoogle Scholar
  36. 36.
    Good, P. F., Hsu, A., Werner, P., Perl, D. P., and Olanow, C. W. (1998). J. Neuropathol. Exp. Neurol. 57, 338–342.PubMedGoogle Scholar
  37. 37.
    Dennis, J. and Bennett, J. P. Jr. (2003). J. Neurosci. Res. 72, 89–97.PubMedCrossRefGoogle Scholar
  38. 38.
    Schapira, A. H., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., and Marsden, C. D. (1990). J. Neurochem. 54, 823–827.PubMedCrossRefGoogle Scholar
  39. 39.
    Gu, M., Cooper, J. M., Taanman, J. W., and Schapira, A. H. (1998). Ann. Neurol. 44, 177–186.PubMedCrossRefGoogle Scholar
  40. 40.
    Swerdlow, R. H., Parks, J. K., Miller, S. W., et al. (1996). Ann. Neurol. 40, 663–671.PubMedCrossRefGoogle Scholar
  41. 41.
    Sheehan, J. P., Swerdlow, R. H., Parker, W. D., Miller, S. W., Davis, R. E., and Tuttle, J. B. (1997). J. Neurochem. 68, 1221–1233.PubMedCrossRefGoogle Scholar
  42. 42.
    Vila, M. and Przedborski, S. (2003). Nat. Rev. Neurosci. 4, 365–375.PubMedCrossRefGoogle Scholar
  43. 43.
    Hartmann, A., Hunot, S., Michel, P. P., et al. (2000). Proc. Natl. Acad. Sci. USA 97, 2875–2880.PubMedCrossRefGoogle Scholar
  44. 44.
    Yang, L., Matthews, R. T., Schulz, J. B., et al. (1998). J. Neurosci. 18, 8145–8152.PubMedGoogle Scholar
  45. 45.
    Tatton, N. A. and Kish, S. J. (1997). Neuroscience 77, 1037–1048.PubMedCrossRefGoogle Scholar
  46. 46.
    Kreutzberg, G. W. (1996). Trends Neurosci. 19, 312–318.PubMedCrossRefGoogle Scholar
  47. 47.
    Liu, B., Gao, H. M., and Hong, J. S. (2003). Environ. Health Perspect. 111, 1065–1073.PubMedGoogle Scholar
  48. 48.
    Lindsay, R. M., Wiegand, S. J., Altar, C. A., and DiStefano, P. S. (1994). Trends Neurosci. 17, 182–190.PubMedCrossRefGoogle Scholar
  49. 49.
    Qin, L., Liu, Y., Cooper, C., Liu, B., Wilson, B., and Hong, J. S. (2002). J. Neurochem. 83, 973–983.PubMedCrossRefGoogle Scholar
  50. 50.
    Kim, W. G., Mohney, R. P., Wilson, B., Jeohn, G. H., Liu, B., and Hong, J. S. (2000). J. Neurosci. 20, 6309–6316.PubMedGoogle Scholar
  51. 51.
    Hunt, S., Boissiere, F., Faucheux, B., et al. (1996). Neuroscience 72, 355–363.CrossRefGoogle Scholar
  52. 52.
    Hunot, S., Dugas, N., Faucheux, B., et al. (1999). J. Neurosci. 19, 3440–3447.PubMedGoogle Scholar
  53. 53.
    Teismann, P., Vila, M., Choi, D. K., et al. (2003). Ann. NY Acad. Sci. 991, 272–277.PubMedCrossRefGoogle Scholar
  54. 54.
    Teismann, P., Tieu, K., Choi, D. K., et al. (2003). Proc. Natl. Acad. Sci. USA 100, 5473–5478.PubMedCrossRefGoogle Scholar
  55. 55.
    Gao, H. M., Jiang, J., Wilson, B., Zhang, W., Hong, J. S., and Liu, B. (2002). J. Neurochem. 81, 1285–1297.PubMedCrossRefGoogle Scholar
  56. 56.
    Reiter, R. J. (1991). Mol. Cell Endocrinol. 79, C153-C158.PubMedCrossRefGoogle Scholar
  57. 57.
    Gern, W. A. and Ralph, C. L. (1979). Science 204, 183–184.PubMedCrossRefGoogle Scholar
  58. 58.
    Menendez-Pelaez, A., Reiter, R. J., Howes, K. A., et al. (1988). Endocr. Res. 14, 121–130.PubMedCrossRefGoogle Scholar
  59. 59.
    Tan, D. X., Manchester, L. C., Reiter, R. J., et al. (1999). Biochim. Biophys. Acta 1472, 206–214.PubMedGoogle Scholar
  60. 60.
    Hardeland, R. and Poeggeler, B. (2003). J. Pineal Res. 34, 233–241.PubMedCrossRefGoogle Scholar
  61. 61.
    Reiter, R. J. (1991). Endocr. Rev. 12, 151–180.PubMedCrossRefGoogle Scholar
  62. 62.
    Blask, D. E., Sauer, L. A., Dauchy, R. T., Holowachuk, E. W., and Ruhoff, M. S. (1999). Adv. Exp. Med. Biol. 460, 337–343.PubMedCrossRefGoogle Scholar
  63. 63.
    Fraschini, F. and Reiter, R. J. (eds.) (1991). Role of melatonin and pineal peptides in neuroimmunomodulation. Plenum Press: New York.Google Scholar
  64. 64.
    Guerrero, J. M. and Reiter, R. J. (2002). Curr. Top. Med. Chem. 2, 167–179.PubMedCrossRefGoogle Scholar
  65. 65.
    Tan, D. X., Chen, L. D., Poeggeler, B., Manchester, L. C., and Reiter, R. J. (1993). Endocr. J. 1, 57–60.Google Scholar
  66. 66.
    Tan, D. X., Manchester, L. C., Reiter, R. J., et al. (1998). Biochem. Biophys. Res. Commun. 253, 614–620.PubMedCrossRefGoogle Scholar
  67. 67.
    Tan, D. X., Manchester, L. C., Burkhardt, S., et al. (2001). FASEB J. 15, 2294–2296.PubMedGoogle Scholar
  68. 68.
    Barlow-Walden, L. R., Reiter, R. J., Abe, M., et al. (1995). Neurochem. Int. 26, 497–502.PubMedCrossRefGoogle Scholar
  69. 69.
    Mayo, J. C., Sainz, R. M., Antoli, I., Herrera, F., Martin, V., and Rodriguez, C. (2002). Cell Mol. Life Sci. 59, 1706–1713.PubMedCrossRefGoogle Scholar
  70. 70.
    Antolin, I., Rodriguez, C., Sainz, R. M., et al. (1996). FASEB J. 10, 882–890.PubMedGoogle Scholar
  71. 71.
    Sofic, E., Rimpapa, Z., Kundurovic, Z., et al. (2005). J. Neural Transm. 112, 349–358.PubMedCrossRefGoogle Scholar
  72. 72.
    Tan, D. X., Reiter, R. J., Manchester, L. C., et al. (2002). Curr. Top. Med. Chem. 2, 181–197.PubMedCrossRefGoogle Scholar
  73. 73.
    Reiter, R. J., Tan, D. X., and Pappolla, M. A. (2004). Ann. NY Acad. Sci. 1035, 179–196.PubMedCrossRefGoogle Scholar
  74. 74.
    Sewerynek, E., Melchiorri, D., Ortiz, G. G., Poeggeler, B., and Reiter, R. J. (1995). J. Pineal Res. 19, 51–56.PubMedCrossRefGoogle Scholar
  75. 75.
    Mohanan, P. V. and Yamamoto, H. A. (2002). Toxicol. Lett. 129, 99–105.PubMedCrossRefGoogle Scholar
  76. 76.
    Lopez-Burillo, S., Tan, D. X., Mayo, J. C., Sainz, R. M., Manchester, L. C., and Reiter, R. J. (2003). J. Pineal Res. 34, 269–277.PubMedCrossRefGoogle Scholar
  77. 77.
    Mayo, J. C., Tan, D. X., Sainz, R. M., Natarajan, M., Lopez-Burillo, S., and Reiter, R. J. (2003). Biochim. Biophys. Acta 1620, 139–150.PubMedGoogle Scholar
  78. 78.
    Stefulj, J., Hortner, M., Ghosh, M., et al. (2001). J. Pineal Res. 30, 243–247.PubMedCrossRefGoogle Scholar
  79. 79.
    Tan, D. X., Manchester, L. C., Hardeland, R., et al. (2003). J. Pineal Res. 34, 75–78.PubMedCrossRefGoogle Scholar
  80. 80.
    Borlongan, C. V., Yamamoto, M., Takei, N., et al. (2000). FASEB J. 14, 1307–1317.PubMedCrossRefGoogle Scholar
  81. 81.
    Cheung, R. T. (2003). J. Pineal Res. 34, 153–160.PubMedCrossRefGoogle Scholar
  82. 82.
    Reiter, R. J., Tan, D. X., Leon, J., Kilic, U., and Kilic, E. (2005). Exp. Biol. Med. (Maywood.) 230, 104–117.Google Scholar
  83. 83.
    Antolin, I., Mayo, J. C., Sainz, R. M., et al. (2002). Brain Res. 943, 163–173.PubMedCrossRefGoogle Scholar
  84. 84.
    Pappolla, M. A., Simovich, M. J., Bryant-Thomas, T., et al. (2002). J. Pineal Res. 32, 135–142.PubMedCrossRefGoogle Scholar
  85. 85.
    Reiter, R. J., Cabrera, J., Sainz, R. M., Mayo, J. C., Manchester, L. C., and Tan, D. X. (1999). Ann. NY Acad. Sci. 890, 471–485.PubMedCrossRefGoogle Scholar
  86. 86.
    Sandyk, R. (1990). Int. J. Neurosci. 50, 37–53.PubMedGoogle Scholar
  87. 87.
    Miller, J. W., Selhub, J., and Joseph, J. A. (1996). Free Radic. Biol. Med. 21, 241–249.PubMedCrossRefGoogle Scholar
  88. 88.
    Khaldy, H., Escames, G., Leon, J., Vives, F., Luna, J. D., and Acuna-Castroviejo, D. (2000). J. Pineal Res. 29, 100–107.PubMedCrossRefGoogle Scholar
  89. 89.
    Acuna-Castroviejo, D., Coto-Montes, A., Gaia, M. M., Ortiz, G. G., and Reiter, R. J. (1997). Life Sci. 60, L23-L29.Google Scholar
  90. 90.
    Jin, B. K., Shin, D. Y., Jeong, M. Y., et al. (1998). Neurosci. Lett. 245, 61–64.PubMedCrossRefGoogle Scholar
  91. 91.
    Kim, Y. S., Joo, W. S., Jin, B. K., Cho, Y. H., Baik, H. H., and Park, C. W. (1998). Neuroreport 9, 2387–2390.PubMedCrossRefGoogle Scholar
  92. 92.
    Joo, W. S., Jin, B. K., Park, C. W., Maeng, S. H., and Kim, Y. S. (1998). Neuroreport 9, 4123–4126.PubMedCrossRefGoogle Scholar
  93. 93.
    Ortiz, G. G., Crespo-Lopez, M. E., Moran-Moguel, C., Garcia, J. J., Reiter, R. J., and Acuna-Castroviejo, D. (2001). Neuroendocrinol. Lett. 22, 101–108.PubMedGoogle Scholar
  94. 94.
    Dabbeni-Sala, F., Di Santo, S., Franceschini, D., Skaper, S. D., and Giusti, P. (2001). FASEB J. 15, 164–170.PubMedCrossRefGoogle Scholar
  95. 95.
    Leon, J., Acuna-Castroviejo, D., Escames, G., Tan, D. X., and Reiter, R. J. (2005). J. Pineal Res. 38, 1–9.PubMedCrossRefGoogle Scholar
  96. 96.
    Khaldy, H., Escames, G., Leon, J., Bikjdaouene, L., and Acuna-Castroviejo, D. (2003). Neurobiol. Aging 24, 491–500.PubMedCrossRefGoogle Scholar
  97. 97.
    Chen, S. T., Chuang, J. I., Hong, M. H., and Li, E. I. (2002). J. Pineal Res. 32, 262–269.PubMedCrossRefGoogle Scholar
  98. 98.
    Thomas, B. and Mohanakumar, K. P. (2004). J. Pineal Res. 36, 25–32.PubMedCrossRefGoogle Scholar
  99. 99.
    Coulom, H. and Birman, S. (2004). J. Neurosci. 24, 10993–10998.PubMedCrossRefGoogle Scholar
  100. 100.
    Iacovitti, L., Stull, N. D., and Johnston, K. (1997). Brain Res. 768, 317–326.PubMedCrossRefGoogle Scholar
  101. 101.
    Iacovitti, L., Stull, N. D., and Mishizen, A. (1999). Brain Res. 816, 276–285.PubMedCrossRefGoogle Scholar
  102. 102.
    Walkinshaw, G. and Waters, C. M. (1994). Neuroscience 63, 975–987.PubMedCrossRefGoogle Scholar
  103. 103.
    Andersen, J. K. (2001). Bioessays 23, 640–646.PubMedCrossRefGoogle Scholar
  104. 104.
    Mayo, J. C., Sainz, R. M., Uria, H., Antolin, I., Esteban, M. M., and Rodriguez, C. (1998). J. Pineal Res. 24, 179–192.PubMedCrossRefGoogle Scholar
  105. 105.
    Mayo, J. C., Sainz, R. M., Antolin, I., and Rodriguez, C. (1999). Brain Res. 818, 221–227.PubMedCrossRefGoogle Scholar
  106. 106.
    Pappolla, M. A., Sos, M., Omar, R. A., et al. (1997). J. Neurosci. 17, 1683–1690.PubMedGoogle Scholar
  107. 107.
    Feng, Z. and Zhang, J. T. (2004). J. Pineal Res. 37, 257–266.PubMedCrossRefGoogle Scholar
  108. 108.
    Cazevieille, C., Safa, R., and Osborne, N. N. (1997). Brain Res. 768, 120–124.PubMedCrossRefGoogle Scholar
  109. 109.
    Herrera, F., Sainz, R. M., Mayo, J. C., Martin, V., Antolin, I., and Rodriguez, C. (2001). J. Pineal Res. 31, 356–362.PubMedCrossRefGoogle Scholar
  110. 110.
    Jou, M. J., Peng, T. I., Reiter, R. J., Jou, S. B., Wu, H. Y., and Wen, S. T. (2004). J. Pineal Res. 37, 55–70.PubMedCrossRefGoogle Scholar
  111. 111.
    Imam, S. Z., el Yazal, J., Newport, G. D., et al. (2001). Ann. NY Acad. Sci. 939, 366–380.PubMedCrossRefGoogle Scholar
  112. 112.
    Lezoualc’h, F., Sparapani, M., and Behl, C. (1998). J. Pineal Res. 24, 168–178.PubMedCrossRefGoogle Scholar
  113. 113.
    Chetsawang, B., Govitrapong, P., and Ebadi, M. (2004). Neurosci. Lett. 371, 205–208.PubMedCrossRefGoogle Scholar
  114. 114.
    Martin, V., Sainz, R. M., Antolin, I., Mayo, J. C., Herrera, F., and Rodriguez, C. (2002). J. Pineal Res. 33, 204–212.PubMedCrossRefGoogle Scholar
  115. 115.
    Mayo, J. C., Tan, D. X., Sainz, R. M., Lopez-Burillo, S., and Reiter, R. J. (2003). Free Radic. Res. 37, 543–553.PubMedCrossRefGoogle Scholar
  116. 116.
    Armstrong, K. J. and Niles, L. P. (2002). Neuroreport 13, 473–475.PubMedCrossRefGoogle Scholar
  117. 117.
    Chung, S. Y. and Han, S. H. (2003). J. Pineal Res. 34, 95–102.PubMedCrossRefGoogle Scholar
  118. 118.
    Martin, M., Macias, M., Leon, J., Escames, G., Khaldy, H., and Acuna-Castroviejo, D. (2002). Int. J. Biochem. Cell Biol. 34, 348–357.PubMedCrossRefGoogle Scholar
  119. 119.
    Martin, M., Macias, M., Escames, G., Leon, J., and Acuna-Castroviejo, D. (2000). FASEB J. 14, 1677–1679.PubMedGoogle Scholar
  120. 120.
    Acuna, C. D., Escames, G., Carazo, A., Leon, J., Khaldy, H., and Reiter, R. J. (2002). Curr. Top. Med. Chem. 2, 133–151.PubMedCrossRefGoogle Scholar
  121. 121.
    Boeve, B. F., Silber, M. H., and Ferman, T. J. (2003). Sleep Med. 4, 281–284.PubMedCrossRefGoogle Scholar
  122. 122.
    Boeve, B. F., Silber, M. H., and Ferman, T. J. (2004). J. Geriatr. Psychiatry Neurol. 17, 146–157.PubMedCrossRefGoogle Scholar
  123. 123.
    Bruguerolle, B. and Simon, N. (2002). Clin. Neuropharmacol. 25, 194–201.PubMedCrossRefGoogle Scholar
  124. 124.
    Sandyk, R. (1990). Int. J. Neurosci. 51, 73–77.PubMedGoogle Scholar
  125. 125.
    Bordet, R., Devos, D., Brique, S., et al. (2003). Clin. Neuropharmacol. 26, 65–72.PubMedCrossRefGoogle Scholar
  126. 126.
    Stull, N. D., Polan, D. P., and Iacovitti, L. (2002). Brain Res. 931, 181–185.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  • Juan C. Mayo
    • 1
  • Rosa M. Sainz
    • 1
  • Dun-Xian Tan
    • 2
  • Isaac Antolín
    • 1
  • Carmen Rodríguez
    • 1
  • Russel J. Reiter
    • 2
    Email author
  1. 1.Departamento de Morfología y Biología Celular, School of MedicineUniversity of OviedoOviedoSpain
  2. 2.Department of Cellular and Structural BiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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