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Secretion of leptin throughout pregnancy and early postpartum period in Japanese Monkeys

Placenta as another potential source of leptin

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An Erratum to this article was published on 01 August 2005

Abstract

Leptin is one of the most important factors linking nutrition and reproduction. In the present study, plasma concentrations of leptin during pregnancy and early lactation in the Japanese monkey were determined. Plasma concentrations of gonadotropins, immunoreactive (ir-)inhibin, and steroid hormones were also measured. Plasma concentrations of leptin significantly increased during the second quarter of pregnancy and progressively elevated throughout pregnancy. During the fourth quarter of pregnancy, leptin levels reached up to 89 and 64 times of those during pre-pregancy and first quarter of pregnancy periods, respectively. After parturition, the circulating leptin level abruptly decreased. During the first 10 d of lactation, its average level decreased to the levels of the second quarter of pregnancy. Plasma ir-inhibin and estradiol-17β were elevated throughout the pregnancy and decreased after parturition, and both of them were positively correlated with leptin levels during the whole pregnancy and early lactation. Plasma concentrations of progesterone significantly increased during the first quarter of pregnancy and kept at a higher level compared with pre-pregnancy and sharply decreased after parturition. Placental homogenates contain a large amount of leptin protein. These results suggest that placenta secretes a large amount of leptin and may be another source of leptin during pregnancy in Japanese monkeys. In addition, high correlations among leptin, ir-inhibin, and estradiol-17β during these stages suggest that these hormones may have important regulating roles on leptin secretion during pregnancy in the Japanese monkey.

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Authors and Affiliations

  1. College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, China

    Cheng Wang

  2. Department of Theriogenology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

    Mohamed S. Medan

  3. Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, 484-8506, Aichi, Japan

    Keiko Shimizu & Mariko Itoh

  4. Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, 501-1183, Gifu, Japan

    Gen Watanabe & Kazuyoshi Taya DVM, PhD

  5. Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu, 183-8509, Tokyo, Japan

    Cheng Wang, Mohamed S. Medan, Chihiro Kojima, Gen Watanabe & Kazuyoshi Taya DVM, PhD

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  1. Cheng Wang
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  2. Mohamed S. Medan
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  3. Keiko Shimizu
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Correspondence to Kazuyoshi Taya DVM, PhD.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s12020-005-0002-z.

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Wang, C., Medan, M.S., Shimizu, K. et al. Secretion of leptin throughout pregnancy and early postpartum period in Japanese Monkeys. Endocr 27, 75–81 (2005). https://doi.org/10.1385/ENDO:27:1:075

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  • DOI: https://doi.org/10.1385/ENDO:27:1:075

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