Skip to main content
SpringerLink
Log in

Plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men

  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Adiponectin, an adipocyte-derived protein, seems to be a link between obesity, insulin resistance, and atherosclerosis. The present study investigated the association between adiponectin and coronary artery disease in middle-aged men. Material and methods: We examined 48 men (aged 40–60) with angiographically confirmed coronary atherosclerosis and 19 healthy men, matched by age, as a control group. Concentrations of glucose and lipids were estimated with enzymatic methods. Plasma level of adiponectin, total and free testosterone, estradiol, estrone, DHEA-S, and insulin were estimated with RIA commercial kits. Results: Men with coronary atherosclerosis had lower plasma adiponectin level than controls (16.2±9.2 vs 20.5±6.7 µg/mL; p<0.05). However, after including BMI and waist as covariate data in ANCOVA, the difference in adiponectin levels between men with CAD and controls lost statistical significance (respectively for BMI and waist: p=0.4 and p=0.7). Moreover, although not significant, adiponectin levels decreased as a function of the number of significantly narrowed coronary arteries. In a priori comparison the lowest adiponectin plasma concentration was in men with three-vessel coronary artery disease (14.3±9.8 µg/mL) and the highest in controls (20.5±6.8 µg/mL; p=0.09). Adiponectin plasma level correlated negatively (p<0.05) with BMI, waist, percentage of total fat, fasting-insulin-resistance index (FIRI), total cholesterol and triglycerides, and positively with quantitative insulin sensitivity check index (QUICKI), HDL cholesterol, total testosterone, and total testosterone/estradiol ratio. Conclusions: Our data suggest that low plasma adiponectin level is connected with insulin resistance syndrome and atherogenic lipid profile. It seems that adiponectin plays a role in pathogenesis of coronary atherosclerosis, especially in obese and insulin-resistant subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H. F. (1995). J. Biol. Chem. 270, 26746–26749.

    Article  PubMed  CAS  Google Scholar 

  2. Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001). Nat. Med. 7, 947–953.

    Article  PubMed  CAS  Google Scholar 

  3. Kazumi, Y., Kawaguchi, A., Sakai, K., Hirano, T., and Yoshino, G. (2002). Diabetes Care 25, 971–976.

    Article  PubMed  Google Scholar 

  4. Matsubara, M., Maruoka, S., and Katayose, S. (2002). J. Clin. Endocrinol. Metab. 87, 2764–2769.

    Article  PubMed  CAS  Google Scholar 

  5. Yamauchi, T., Kamon, J., Waki, H., et al. (2001). Nat. Med. 7, 941–946.

    Article  PubMed  CAS  Google Scholar 

  6. Fruebis, J., Tsao, T. S., Javorschi, S., et al. (2001). Proc. Natl. Acad. Sci. USA 98, 2005–2010.

    Article  PubMed  CAS  Google Scholar 

  7. Stefan, N., Bunt, J. C., Salbe, A. D., Funahashi, T., Matsuzawa, Y., and Tataranni, A. (2002). J. Clin. Endocrinol. Metab. 87, 4652–4656.

    Article  PubMed  CAS  Google Scholar 

  8. Ouchi, N., Kihara, S., Arita, Y., et al. (1999). Circulation 100, 2473–2476.

    PubMed  CAS  Google Scholar 

  9. Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., and Ouschi, N. (2000). Blood 96, 1723–1732.

    PubMed  CAS  Google Scholar 

  10. Kihara, S., Arita,Y., Ouchi, N., Maeda, K., Masahiko, T., and Yamashita, S. (1998). Int. J. Obesity 22 (Suppl. 3), O16 [Abstract].

  11. Matsuda, M., Shimomura, I., Sata, M., et al. (2002). J. Biol. Chem. 277, 37487–37491.

    Article  PubMed  CAS  Google Scholar 

  12. Lindsay, R. S., Funahashi, T., Hanson, R. L., et al. (2002). Lancet 360, 57–58.

    Article  PubMed  CAS  Google Scholar 

  13. Kondo, H., Shimomura, I., Matsukawa, Y., et al. (2002). Diabetes 51, 2325–2328.

    Article  PubMed  CAS  Google Scholar 

  14. Weyer, C., Funahashi, T., Tanaka, S., et al. (2001). J. Clin. Endocrinol. Metab. 86, 1930–1935.

    Article  PubMed  CAS  Google Scholar 

  15. Hotta, K., Funahashi, T., Arita, Y., et al. (2000). Arterioscler. Thromb. Vasc. Biol. 20, 1595–1599.

    PubMed  CAS  Google Scholar 

  16. Yang, W. S., Lee, W. J., Funahashi, T., et al. (2001). J. Clin. Endocrinol. Metab. 86, 3815–3819.

    Article  PubMed  CAS  Google Scholar 

  17. Wajchenberg, B. L. (2000). End. Rev. 21, 637–738.

    Google Scholar 

  18. McFarlane, S. I., Banerji, M., and Siwers, J. R. (2001). J. Clin. Endocrinol. Metab. 86, 713–718.

    Article  PubMed  CAS  Google Scholar 

  19. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. (2001). JAMA 285, 2486–2497.

    Article  Google Scholar 

  20. Ohashi, K., Ouchi, N., Kihara, S., et al. (2004). J. Am. Coll. Cardiol. 43, 1195–1200.

    Article  PubMed  CAS  Google Scholar 

  21. Ouchi, N., Kihara, S., Funahashi, T., et al. (2003). Circulation 107, 671–674.

    Article  PubMed  CAS  Google Scholar 

  22. Kumada, M., Kihara, S., Sumitsuji, S., et al. (2003). Arterioscler. Thromb. Vasc. Biol. 23, 85–89.

    Article  PubMed  CAS  Google Scholar 

  23. Dzielinska, Z., Januszewicz, A., Wiecek, A., et al. (2003). Thromb. Res. 110, 365–369.

    Article  PubMed  CAS  Google Scholar 

  24. Nakamura, Y., Shimada, K., Fukuda, D., et al. (2004). Heart 90, 528–533.

    Article  PubMed  CAS  Google Scholar 

  25. Shimada, K., Miyauchi, K., Mokuno, H., et al. (2002). Jpn. Heart J. 43, 85–91.

    Article  PubMed  CAS  Google Scholar 

  26. Arita, Y., Kihara, S., Ouchi, N., et al. (1999). Biochem. Biophys. Res. Commun. 257, 79–83.

    Article  PubMed  CAS  Google Scholar 

  27. Yamamoto, Y., Hirose, H., Saito, I., et al. (2002). Clin. Sci. (Lond.) 103, 137–142.

    CAS  Google Scholar 

  28. Philips, G., Pinkernell, B. H., and Jing, T. Y. (1994). Arterioscler. Thromb. 14, 701–706.

    Google Scholar 

  29. Glueck, C. J., Glueck, H. I., Stroop, D., Speirs, J., Hamer, T., and Tracy, T. (1993). J. Lab. Clin. Med. 122, 412–420.

    PubMed  CAS  Google Scholar 

  30. Khaw, K. T. and Barrett-Connor, E. (1991). Arterioscler. Thromb. 11, 489–494.

    PubMed  CAS  Google Scholar 

  31. Xu, T., Wang, X., Hou, S., Zhu, J., Zhang, X., and Huang, X. (2002). Chin. Med. J. (Engl.) 115, 1336–1340.

    Google Scholar 

  32. Simon, D., Charles, M. A., Nahoul, K., et al. (1997). J. Clin. Endocrinol. Metab. 82, 682–685.

    Article  PubMed  CAS  Google Scholar 

  33. Nishizawa, H., Shimomura, I., Kishida, K., et al. (2002). Diabetes 51, 2734–2741.

    Article  PubMed  CAS  Google Scholar 

  34. Word Health Organization (1999). J. Hypertension 17, 905–918.

    Google Scholar 

  35. Greenfield, J. R., Samaras, K., and Chisholm, D. J. (2002). J. Clin. Endocrinol. Metab. 87, 1036–1040.

    Article  PubMed  CAS  Google Scholar 

  36. Mock, M. B., Ringqvist, I., Fisher, L. D., Davis, K. B., and Chaitman, B. R. (1982). Circulation 66, 562–568.

    PubMed  CAS  Google Scholar 

  37. Fletcher, G. F., Balady, G. J., Amsterdam, E. A., et al. (2001). Circulation 104, 1694–1740.

    PubMed  CAS  Google Scholar 

  38. Katz, A., Nambi, S. S., Mather, K., et al. (2000). J. Clin. Endocrinol. Metab. 85, 2402–2410.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Endocrinology and Diabetology, Wroclaw Medical University, Poland

    Andrzej Milewicz, Diana Jcedrzejuk & Jadwiga Szymczak

  2. Department of Cardiology, Wroclaw Medical University, Poland

    Wiktor Kuliczkowski, Piotr Salomon, Dariusz Biały, Karol Poczcatek & Przemysław Nowicki

  3. Dept. of Health Promotion and Hygiene, Wroclaw University of Physical Education, al. Paderewskiego 35 (P-3, p. 200), Wroclaw, Poland

    Katarzyna Dunajska

Authors
  1. Katarzyna Dunajska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrzej Milewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Diana Jcedrzejuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jadwiga Szymczak
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Wiktor Kuliczkowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Piotr Salomon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dariusz Biały
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Karol Poczcatek
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Przemysław Nowicki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Katarzyna Dunajska.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dunajska, K., Milewicz, A., Jcedrzejuk, D. et al. Plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men. Endocr 25, 215–221 (2004). https://doi.org/10.1385/ENDO:25:3:215

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/ENDO:25:3:215

Key Words

Search

Navigation