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Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist increases plasma adiponectin levels in type 2 diabetic patients with proteinuria

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Abstract

Adiponectin appears to be an important modulator for metabolic and vascular diseases. A case-controlled study was designed to measure plasma adiponectin levels and investigate the effects of rosiglitazone on adiponectin levels in type 2 diabetic patients with proteinuria. Sixty-four patients (mean age, 46.1±4.6 yr; 30 male, 34 female) and 26 healthy volunteers (mean age, 45.3±4.8 yr; 14 male, 12 female) were included. Patients with proteinuria were treated with 4-mg/d rosiglitazone (n = 21, 10 males, 11 females) for 4 wk. Adiponectin levels in patients were significantly lower than those of controls (p<0.001). There were significant negative correlations between adiponectin concentrations and insulin levels as well as homeostasis model assessment (HOMA) index in patient’s group (r=−0.538, p<0.001; r,=−0.393, p=0.001, respectively). There was also a significant negative correlation between plasma adiponectin concentrations and the degree of proteinuria (r=−0.526, p=0.002). Plasma adiponectin levels in patients with proteinuria ?(n=31; 3.91±2.57 µg/mL) were significantly lower than those without proteinuria (n=33; 10.15±1.97 µg/mL) (p<0.001). After the treatment period, adiponectin levels significantly increased (p<0.001) and proteinuria, plasma insulin, and HOMA indexes significantly decreased in treatment group (p<0.001, p<0.001, p<0.001, respectively). The results suggest that adiponectin is inversely correlated with proteinuria and treatment with peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist rosiglitazone both corrects proteinuria and increases the low adiponectin levels in diabetic patients.

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Authors and Affiliations

  1. Department of Internal Medicine, Gülhane School of Medicine, 06018, Etlik-Ankara, Turkey

    Alper Sonmez, Deniz Engin Gok & Müjdat Yenicesu

  2. Department of Epidemiology, Gülhane School of Medicine, 06018, Etlik-Ankara, Turkey

    Cengizhan Acikel & Selim Kilic

  3. Department of Biochemistry, Bayindir Medical Center, Ankara, Turkey

    Mahmut Ilker Yilmaz MD, Alper Sonmez, Kayser Caglar, Deniz Engin Gok, Tayfun Eyileten, Müjdat Yenicesu, Cengizhan Acikel, Necati Bingol, Selim Kilic, Yusuf Oguz & Abdulgaffar Vural

  4. Department of Nephrology, Gülhane School of Medicine, 06018, Etlik-Ankara, Turkey

    Mahmut Ilker Yilmaz MD, Kayser Caglar, Tayfun Eyileten, Necati Bingol, Yusuf Oguz & Abdulgaffar Vural

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  1. Mahmut Ilker Yilmaz MD
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Correspondence to Mahmut Ilker Yilmaz MD.

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Yilmaz, M.I., Sonmez, A., Caglar, K. et al. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist increases plasma adiponectin levels in type 2 diabetic patients with proteinuria. Endocr 25, 207–214 (2004). https://doi.org/10.1385/ENDO:25:3:207

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  • DOI: https://doi.org/10.1385/ENDO:25:3:207

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