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The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2

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Abstract

We initiated the present work to determine whether the presence of the HFE C282Y or H63D mutations could be related to the clinical expression of diabetes mellitus type 2. Two hundred and twenty five type 2 consecutive diabetic patients were included and the HFE genotypes were determined. Younger ages of onset of diabetes as well as a longer duration of the disease were detected in patients carrying at least one C282Y allele (p=0.007). An increased prevalence of retinopathy (p=0.014) and of nephropathy (p=0.04) were also detected in individuals carrying at least one C282Y allele in comparison with patients carrying the other alleles. The increased prevalence of retinopathy in C282Y carriers is related to the increased duration of the disease, but we not have detected that the prevalence of nephropathy is associated with the duration of the disease. However, multivariate logistic regression confirms that the prevalence of nephropathy is higher in the group of patients carrying at least one C282Y allele or the H63D/H63D genotype as compared to the group of patients with the wild-type (N/N) or the N/H63D genotype. To our knowledge our study is the first one to report an earlier age of onset in type 2 diabetic patients carrying HFE mutations.

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Authors and Affiliations

  1. Grup de Genètica Molecular, Hospital Clínic and Faculty of Medicine, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Spain

    Rafael Oliva MD PhD, Mayka Sánchez, Marga Villa & Mercedes Ingelmo

  2. Fundació Sardà Farriol, Spain

    Anna Novials & Mónica Recasens

  3. Biostatistics Unit, Department of Public Health, IDIBAPS, Faculty of Medicine, University of Barcelona, Spain

    Carlos Ascaso

  4. Hepatology Unit, Hospital Clínic, IDIBAPS, Spain

    Miquel Bruguera

  5. Servicio de Endocrinología y Diabetes, Hospital Clínic, IDIBAPS, Barcelona, Spain

    Ramón Gomis

Authors
  1. Rafael Oliva MD PhD
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  2. Anna Novials
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  3. Mayka Sánchez
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  4. Marga Villa
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  5. Mercedes Ingelmo
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  6. Mónica Recasens
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  7. Carlos Ascaso
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  8. Miquel Bruguera
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  9. Ramón Gomis
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Correspondence to Rafael Oliva MD PhD.

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Oliva, R., Novials, A., Sánchez, M. et al. The HFE gene is associated to an earlier age of onset and to the presence of diabetic nephropathy in diabetes mellitus type 2. Endocr 24, 111–114 (2004). https://doi.org/10.1385/ENDO:24:2:111

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  • DOI: https://doi.org/10.1385/ENDO:24:2:111

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