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Alzheimer’s disease

Pathophysiological implications of measurement of plasma cortisol, plasma dehydroepiandrosterone sulfate, and lymphocytic corticosteroid receptors

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Abstract

Alzheimer’s disease is often characterized by an increase in plasma cortisol without clinical evidence of hypercorticism. Twenty-three consecutive patients with Alzheimer’s disease and 23 age- and sex-matched healthy controls were studied by measuring plasma cortisol and dehydroepiandrosterone sulfate (DHEAS) (by enzyme immunoassay), the number of type I and type II corticosteroid receptors in mononuclear leukocytes (by radioreceptorassay), and the lymphocyte subpopulations (by cytofluorimetry). Results are expressed in terms of median and range. In Alzheimer’s disease, plasma cortisol was higher than in controls (median 0.74, range 0.47–1.21 vs 0.47, 0.36–0.77 mmol/L; p<0.001). Plasma DHEAS, the DHEAS/cortisol ratio, and the number of type II corticosteroid receptors were significantly lower in AD than in controls (DHEAS: median 1.81, range 0.21–3.69 vs 3.51, 1.35–9.07 µmol/L; DHEAS/cortisol: 2.04, range 0.3–5.8 vs 6.8, range 2.7–24 and type II receptors: 1219, 1000–2700 vs 1950, 1035–2750 receptors per cell; p<0.001). No correlation was found between the hormonal parameters, age, and minimental test score. These data support the hypothesis of a dysregulation of the adrenal pituitary axis in Alzheimer’s disease, which is probably the consequence of damage to target tissues by corticosteroids.

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Authors and Affiliations

  1. Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100, Padua, Italy

    Decio Armanini MD, Maria Simoncini, Cristina Fiore, Mee Joung Mattarello & Paola Sartorato

  2. Neurology Mirano Hospital, Venice

    Franco Vecchio

  3. Metabolic Unit, Vicenza Hospital, Padua, Italy

    Alfonso Basso

  4. Neurology, Vicenza Hospital, Padua, Italy

    Francesco Ferro Milone

  5. Clinical Pathology, Piove di Sacco Hospital, Padua, Italy

    Isabella Karbowiak

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  1. Decio Armanini MD
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  2. Franco Vecchio
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  3. Alfonso Basso
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  4. Francesco Ferro Milone
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  5. Maria Simoncini
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  9. Isabella Karbowiak
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Correspondence to Decio Armanini MD.

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Armanini, D., Vecchio, F., Basso, A. et al. Alzheimer’s disease. Endocr 22, 113–118 (2003). https://doi.org/10.1385/ENDO:22:2:113

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  • DOI: https://doi.org/10.1385/ENDO:22:2:113

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