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Growth hormone-releasing hormone and growth hormone secretagogues in normal aging

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Abstract

Growth hormone (GH) secretion declines with aging, and parallels between normal aging and the signs and symptoms of adult GH deficiency have led to interest in the potential utility of replacing or stimulating GH to promote physical and psychological function and to prolong the capacity for independent living in older adults. The aging pituitary remains responsive to GH-releasing hormone (GHRH) and to ghrelin-mimetic GH secretagogues (GHS), and these agents have both theoretical and practical potential advantages as alternatives to the use of GH itself in this setting. Studies of the long duration and large scale needed to test the efficacy of GHRH or GHS on clinically important endpoints cannot be designed or conducted without first obtaining promising results in studies of smaller size focused on manageable intermediate endpoints, and all studies published to date have been of this latter type. GHRH and GHS both stimulate GH secretion, and, when given repeatedly, elevate IGF-I levels to within younger adult normal ranges. When GHRH treatment is continued for several months, these hormonal changes yield an increase in lean body (muscle) mass. GHRH, like GH, reduces body fat, but similar effects have not yet been shown with GHS. GHRH treatment has not yielded consistent improvements in physical function, although it may have a stabilizing effect. Chronic treatment with a short-acting GHRH did not improve sleep, possibly due to lack of sustained activity throughout the night. Compared to placebo, GHRH treatment improved certain tests of cognitive performance. These results, while encouraging, do not yet support the routine use of GHRH or GHS in normal aging.

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References

  1. Gelato, M. C. and Merriam, G. R. (1986). Ann. Rev. Physiology 48, 569–591.

    Article  CAS  Google Scholar 

  2. Bowers, C. Y., Sartor, A. O., Reynolds, G. A., and Badger, T. M. (1991). Endocrinology 128, 2027–2035.

    PubMed  CAS  Google Scholar 

  3. Bowers, C. Y. (1998). Cell. Molec. Life Sci. 54, 1316–1329.

    Article  PubMed  CAS  Google Scholar 

  4. Pong, S. S., Chaung, L. Y., Dean, D. C., Nargund, R. P., Patchett, A. A., and Smith, R. G. (1996). Mol. Endocrinol. 10, 57–61.

    Article  PubMed  CAS  Google Scholar 

  5. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., and Kangawa, K. (1999). Nature 402, 656–660.

    Article  PubMed  CAS  Google Scholar 

  6. Patchett, A. A., Nargund, R. P., Tata, J. R., et al. (1995). Proc. Natl. Acad. Sci. USA 92, 7001–7005.

    Article  PubMed  CAS  Google Scholar 

  7. Cummings, D. E. and Schwartz, M. W. (2003). Ann. Rev. Med. 54, 453–471.

    Article  PubMed  CAS  Google Scholar 

  8. Cowley, M. A., Smith, R. G., Diano, S., et al. (2003). Neuron 37, 550–553.

    Article  Google Scholar 

  9. Tannenbaum, G. S., Epelbaum, J., and Bowers, C. Y. (2003). Endocrinology 144, 967–974.

    Article  PubMed  CAS  Google Scholar 

  10. Kletke, M. L., Cummings, D. E., Frayo, R. S., et al. (2003). Endocrine Society Annual Meeting, Philadelphia, PA, 21 June, abstract OR32-4.

  11. Ohlsson, C., Sjogren, K., Jansson, J. O., and Isaksson, O. G. (2000). Pediatr. Nephrol. 14, 541–543.

    Article  PubMed  CAS  Google Scholar 

  12. Pavlov, E. P., Harman, S. M., Merriam, G. R., Gelato, M. C., and Blackman, M. R. (1986). J. Clin. Endocrinol. Metab. 62, 595–600.

    PubMed  CAS  Google Scholar 

  13. Ghigo, E., Goffi, S., Nicolosi, M., et al. (1990). J. Clin. Endocrinol. Metab. 71, 1481–1485.

    Article  PubMed  CAS  Google Scholar 

  14. Chapman, I. M., Hartman, M. L., Pezzoli, S. S., et al. (1997). J. Clin. Endocrinol. Metab. 82, 2996–3004.

    Article  PubMed  CAS  Google Scholar 

  15. Ho, K. Y., Evans, W. S., Blizzard, R. M., et al. (1987). J. Clin. Endocrinol. Metab. 64, 51–58.

    PubMed  CAS  Google Scholar 

  16. Vitiello, M. V., Schwartz, R. S., Buchner, D. R., Moe, K. E., Mazzoni, G., and Merriam, G. R. (2001). Dialogs Clin. Neurosci. 3, 229–236.

    Google Scholar 

  17. Alexandre, B., Allas, S., de Villars, A., et al. (2003). Endocrine Society Annual Meeting, Philadelphia, PA, 20 June, abstract P2-372.

  18. Mericq, V., Cassorla, F., Bowers, C. Y., Avila, A., Gonen, B., and Merriam, G. R. (2003). J. Ped. Endocrinol. Metab. 16, 981–985.

    CAS  Google Scholar 

  19. Svensson, J., Lonn, L., Jansson, J.-O., et al. (1998). J. Clin. Endocrinol. Metab. 83, 362–369.

    Article  PubMed  CAS  Google Scholar 

  20. Bengtsson, B.-Å., Edén, S., Ernest, I., Oden, A., and Sjogren, B. (1988). Acta Med. Scand. 223, 327–335.

    Article  PubMed  CAS  Google Scholar 

  21. Chan, J. M., Stampfer, M. J., and Giovanucci, E. (1998). Science 279, 563–566.

    Article  PubMed  CAS  Google Scholar 

  22. Hankinson, S. E., Willett, W. C., and Colditz, G. A. (1998). Lancet 351, 1373–1375.

    Article  Google Scholar 

  23. Fradkin, J. E., Mills, J. L., Schonberger, L. B., et al. (1993). J. Am. Med. Assoc. 270, 2829–2832.

    Article  CAS  Google Scholar 

  24. Swerdlow, A. J., Higgins, C. D., Adlard, P., and Preece, M. A. (2002). Lancet 360, 273–277.

    Article  PubMed  CAS  Google Scholar 

  25. Corpas, E., Harman, S. M., Pineyro, M. A., Roberson, R., and Blackman, M. R. (1992). J. Clin. Endocrinol. Metab. 75, 530–535.

    Article  PubMed  CAS  Google Scholar 

  26. Corpas, E., Harman, S. M., Pineyro, M. A., Roberson, R., and Blackman, M. R. (1993). J. Clin. Endocrinol. Metab. 76, 134–138.

    Article  PubMed  CAS  Google Scholar 

  27. Khorram, O., Laughlin, G. A., and Yen, S. S. C. (1997). J. Clin. Endocrinol. Metab. 82, 1472–1479.

    Article  PubMed  CAS  Google Scholar 

  28. Schwartz, R. S., Buchner, D., Merriam, G., Cress, E., and Vitiello, M. (2000). Endocrine Society Annual Meeting, Toronto, 47 (abstract 218).

  29. Schwartz, R., Merriam, G., Vitiello, M., Barsness, S., Hastings, R., and Buchner, D. (2000). J. Am. Geriatrics Soc. 48, S115.

    Google Scholar 

  30. Schwartz, R., Merriam, G., Cress, M., et al. (2000). J. Am. Geriatrics Soc. 48, S116.

  31. Cress, M. E., Buchner, D. M., Questad, K. A., Esselman, P. C., deLateur, B. J., and Schwartz, R. S. (1999). J. Gerontol. A. Biol. Sci. Med. Sci. 54, M242-M248.

    PubMed  CAS  Google Scholar 

  32. Vitiello, M. V., Mazzoni, G., Moe, K. E., et al. (2000). The Gerontologist 40, 39.

    Google Scholar 

  33. Vitiello, M. V., Buchner, D. R., Cress, M. E., et al. (2001). The Gerontologist 41, 66.

    Google Scholar 

  34. Vitiello, M. V., Mazzoni, G., Moe, K. E., et al. (2002). J. Clin. Psych. 63, 1084.

    Google Scholar 

  35. Merriam, G. R., Galt, S., Drolet, G., et al. (1999). J. Invest. Med. 47, 23A.

  36. Kletke, M. L., Barsness, S., Drolet, G., et al. (2000). J. Invest. Med. 48, 337A.

  37. Burman, P., Johansson, A., Siegbahn, A., Vessby, B., and Karlsson, F. (1997). J. Clin. Endocrinol. Metab. 82, 550–555.

    Article  PubMed  CAS  Google Scholar 

  38. Cook, D. M., Ludlum, W. H., and Cook, D. M. (1999). J. Clin. Endocrinol. Metab. 84, 3956–3960.

    Article  PubMed  CAS  Google Scholar 

  39. Merriam, G. R., Barsness, S., Drolet, G., et al. (2000). Endocrine Society Annual Meeting, Toronto, 395 (abstract 1634).

  40. Vitiello, M. V., Wilkinson, C. W., Merriam, G. R., et al. (1997). J. Gerontol. Med. Sci. 52A, 149–154.

    Google Scholar 

  41. Merriam, G. R., Barsness, S., Drolet, G., et al. (1999). Endocrine Society, San Diego, CA, abstract OR9-6.

  42. Vitiello, M. V., Moe, K. E., Larsen, L. H., Merriam, G. R., and Schwartz, R. S. (2003). Sleep 26, A154.

    Google Scholar 

  43. Bowers, C. Y. and Granda-Ayala, R. (2001). Endocrine 14, 79–86.

    Article  PubMed  CAS  Google Scholar 

  44. Chapman, I. M., Bach, M. A., van Cauter, E., et al. (1996). J. Clin. Endocrinol. Metab. 81, 4249–4257.

    Article  PubMed  CAS  Google Scholar 

  45. Murphy, M. G., Bach, M. A., Plotkin, D., et al. (1999). J. Bone Min. Res. 14, 1182–1188.

    Article  CAS  Google Scholar 

  46. Thorner, M. O. (2001). The somatopause, Endocrine Society Annual Meeting, Denver, CO, 20 (abstract L5-2)

  47. Hensley, S. (2002). Wall Street Journal, May 2.

  48. Blackman, M. R., Sorkin, J. D., Munzer, T., et al. (2002). J. Am. Med. Assoc. 288, 2282–2292.

    Article  CAS  Google Scholar 

  49. Cummings, D. E. and Merriam, G. R. (2003). Ann. Rev. Med. 54, 513–533.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research (A-151), VA Puget Sound Health Care System, 98493, Tacoma, WA

    George R. Merriam

  2. Department of Medicine, University of Washington, Seattle, Washington

    George R. Merriam & Robert S. Schwartz

  3. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington

    Michael V. Vitiello

  4. Division of Geriatric Medicine, University of Colorado Health Sciences Center, Denver, Colorado

    Robert S. Schwartz

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  1. George R. Merriam
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  2. Robert S. Schwartz
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  3. Michael V. Vitiello
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Correspondence to George R. Merriam.

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Merriam, G.R., Schwartz, R.S. & Vitiello, M.V. Growth hormone-releasing hormone and growth hormone secretagogues in normal aging. Endocr 22, 41–48 (2003). https://doi.org/10.1385/ENDO:22:1:41

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  • DOI: https://doi.org/10.1385/ENDO:22:1:41

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