Asymmetric effects of acute hemiovariectomy on steroid hormone secretion by the In situ ovary
The acute effects of hemiovariectomy on progesterone, testosterone, estradiol, and luteinizing hormone (LH) concentrations in serum were studied in rats under the following experimental conditions: control, sham-operated (left or right), hemiovariectomized, bilateral adrenalectomized, and hemiovariectomized plus bilateral adrenalectomized. One-hour after surgery, the concentration of progesterone and testosterone in the serum of right-side sham-operated rats was significantly higher than in control animals. Testosterone concentration in serum in rats with the right ovary in situ was higher than in sham-operated animals; injecting atropine sulfate 1 h before surgery blocked such increase, while the same treatment to rats with the left ovary remaining in situ resulted in a significant increase of testosterone concentration. Adrenalectomy resulted in an increase of testosterone concentration, which was higher when atropine sulfate was injected before surgery. Our results support the idea that left and right ovaries play different roles in the regulation of hormone secretion, and that such differences are related to ovarian innervation.
Key WordsAsymmetry estrus day hemiovariectomy adrenalectomy steroid secretion
Unable to display preview. Download preview PDF.
- 1.Greenwald, G. S. and Roy, S. K. (1994). In: The physiology of reproduction. Knobil, E. and Neild, J. D. (eds.). Raven Press: New York.Google Scholar
- 9.Domínguez, R., Cruz, M. E., and Chávez, R. (1988). In: Growth factors and the ovary. Hirshfield, A. N. (ed.). Plenum Press: New York.Google Scholar
- 17.Ojeda, S. and Urbanski, H. F. (1994). In: The physiology of reproduction. Knobil, E. and Neill, J. D. (eds.). Raven Press: New York.Google Scholar
- 18.Burden, H. W. (1978). The vertebrate ovary. In: Comparative biology. Jones, R. E. (ed.). Plenum Press: New York.Google Scholar
- 25.Chen, L. W., Guan, Z. L., and Ding, Y. Q. (1997). J. Hirnforschung. 38, 363–367.Google Scholar
- 27.Nakamura, Y., Kato, H., and Terranova, P. F. (1992). Endocrinol. Jap. 39, 141–145.Google Scholar