Endocrine

, Volume 16, Issue 3, pp 151–165 | Cite as

Recent discoveries in physiology of insulin-like growth factor-1 and its interaction with gonadotropins in folliculogenesis

  • F. Khamsi
  • S. Roberge
  • Y. Yavas
  • I. C. Lacanna
  • X. Zhu
  • J. Wong
Review

Abstract

Ovarian follicular development is under the influence of gonadotrophins. The manner by which gonadotrophins achieve their role in cell replication and hormone production is through other specialized molecules. Insulin-like growth factor-1 (IGF-1) is considered to be one of the most important of these molecules. IGF-1 is present in relatively large amounts in the ovary and the IGF-1 gene is expressed in the graafian follicle. IGF-1 binding proteins modulate the action of IGF-1 and are influenced by gonadotrophins. Null mutations of genes encoding IGF-1 and type-1 IGF receptor have demonstrated the obligatory role of IGF-1 in folliculogenesis. It was proposed that IGF-1 may be an obligatory mediator of gonadotrophin-induced folliculogenesis and that the interaction is synergistic.

From this point, one group embarked on a series of physiological studies to further elucidate the interaction of these molecules. We discovered that, according to circumstances, follicle stimulating hormone (FSH) may act with IGF-1 synergistically (as was postulated before), additively, independently, or even antagonistically. We discovered that granulosa cells must first be exposed to FSH and then they respond well to IGF-1. All previous studies of granulosa cells were done on mural granulosa cells. We subsequently showed that cumulus type of granulosa cells (adjacent to the oocyte) behave differently in their responses to gonadotrophins and IGF-1.

Key Words

Insulin-like growth factor-1 follicle-stimulating hormone luteinizing hormone granulosa cells cumulus cells DNA synthesis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Dorrington, J. H. and Armstrong, D. T. (1979). Recent Prog. Horm. Res. 35, 301–342.PubMedGoogle Scholar
  2. 2.
    Richards, J. S. (1980). Physiol. Rev. 60, 51–89.PubMedGoogle Scholar
  3. 3.
    Savion, N., Lui, G.-M., Laherty, R., and Gospodarowicz, D. (1981). Endocrinology 109, 409–417.PubMedGoogle Scholar
  4. 4.
    May, J. V., Frost, J. P., and Schomberg, D. W. (1988). Endocrinology 123, 168–179.PubMedGoogle Scholar
  5. 5.
    Greenwald, G. S. and Terranova, P. F. (1988). In: The physiology of reproduction, vol. 1. Knobil, E. and Neill, J. (eds.). Raven: New York.Google Scholar
  6. 6.
    Adashi, E. Y., Resnick, C. E., D’ercole, A. J., et al. (1985). Endocr. Rev. 6(3), 400–420.PubMedGoogle Scholar
  7. 7.
    Singh, B. and Armstrong, D. T. (1994). Theriogenology 41, 295–301.CrossRefGoogle Scholar
  8. 8.
    Erickson, G. F. and Shimasaki, S. (1996). Department of Reproductive Medicine (0674), University of California.Google Scholar
  9. 9.
    Murphy, L. J., Bell, G. I., and Friesen, H. G. (1987). Endocrinology 120, 1279–1282.PubMedGoogle Scholar
  10. 10.
    Oliver, J. E., Aitman, T. J., Powell, J. F., Wilson, C. A., and Ciayton, R. N. (1989). Endocrinology 124, 2670–2679.Google Scholar
  11. 11.
    Zhou, J., Chin, E., and Bondy, C. (1991). Endocrinology 129, 3281–3288.PubMedGoogle Scholar
  12. 12.
    Hernandez, E. R., Roberts, C. H., LeRoith, D., and Adashi, E. Y. (1989). Endocrinology 125, 572–574.PubMedGoogle Scholar
  13. 13.
    Hansson, H.-A., Nilsson, A., Isgaard, J., Billig, H., Isaksson, O., Skottner, A., Andersson, I. K., and Rozell, B. (1988). Histochemistry 89, 403–410.PubMedCrossRefGoogle Scholar
  14. 14.
    Goldenberg, R. L., Vaitukaitis, J. L., and Ross, G. T. (1972). Endocrinology 90, 1492–1498.PubMedGoogle Scholar
  15. 15.
    Lonergan, P., Monaghan, P., Rizos, D., Boland, M. P., and Gordon, I. (1994). Mol. Reprod. Dev. 37, 48–53.PubMedCrossRefGoogle Scholar
  16. 16.
    Hsu, C.-J. and Hammond, J. M. (1986). Endocrinology 120, 198–207.Google Scholar
  17. 17.
    Hammond, J. M., Hsu, C.-J., Klindt, J., Tsang, B. K., and Downey, B. R. (1988). Biol. Reprod. 38, 304–308.PubMedCrossRefGoogle Scholar
  18. 18.
    Magoffin, D. A. and Erickson, G. F. (1988). Cell. Dev. Biol. 24, 862–870.CrossRefGoogle Scholar
  19. 19.
    Magoffin, D. A., Kurtz, K. M., and Erickson, G. F. (1990). Mol. Endocrinol. 4, 489–496.PubMedGoogle Scholar
  20. 20.
    Hernandez, E. R., Resnick, C. E., Svoboda, M. E., Van Wyk, J. J., Payne, D. W., and Adashi, E. Y. (1988). Endocrinology 122, 1603–1612.PubMedGoogle Scholar
  21. 21.
    Caubo, B., De Vinna, R. S., and Tonetta, S. A. (1989). Endocrinology 125, 321–326.PubMedGoogle Scholar
  22. 22.
    Cara, J. F. and Rosenfield, R. L. (1988). Endocrinology 123, 733–739.PubMedGoogle Scholar
  23. 23.
    Cara, J. F., Fan, J., Azzarello, J., and Rosenfield, R. L. (1990). J. Clin. Invest. 86, 560–565.PubMedGoogle Scholar
  24. 24.
    Magoffin, D. A. and Weitsman, S. R. (1994). Biol. Reprod. 1994; 51, 766–775.PubMedCrossRefGoogle Scholar
  25. 25.
    Magoffin, D. A. and Weitsman, S. R. (1993). Biol. Reprod. 48, 1166–1173.PubMedCrossRefGoogle Scholar
  26. 26.
    Magoffin, D. A. and Weitsman, S. R. (1993). Mol. Cell. Endocrinol. 96, 45–51.PubMedCrossRefGoogle Scholar
  27. 27.
    Magoffin, D. A. and Weitsman, S. R. (1993). Endocrinology 132, 1945–1951.PubMedCrossRefGoogle Scholar
  28. 28.
    Nakatani, A., Shimasaki, S., Erickson, G. F., and Ling, N. (1991). Endocrinology 129, 1521–1529.PubMedGoogle Scholar
  29. 29.
    Erickson, G. F., Nakatani, A., Ling, N., and Shimasaki, S. (1992). Endocrinology 130, 625–636.PubMedCrossRefGoogle Scholar
  30. 30.
    Erickson, G., Nakatani, A., Ling, N., and Shimasaki, S. (1992). Endocrinology 130, 1867–1878.PubMedCrossRefGoogle Scholar
  31. 31.
    Adashi, E. Y., Resnick, C. E., Svoboda, M. E., and Van Wyk, J. J. (1986). Biol. Reprod. 34, 81–88.PubMedCrossRefGoogle Scholar
  32. 32.
    Ricciarelli, E., Hernandez, E. R., Hurwitz, A., Kokia, E., Rosenfeld, R. G., Schwander, J., and Adashi, E. Y. (1991). Endocrinology 129, 2266–2268.PubMedGoogle Scholar
  33. 33.
    Ricciarelli, E., Hernandez, E. R., Kokia, E., Rohan, R. M., Tedeschi, C., Botero, L., Rosenfeld, R. G., Albiston, A. L., Herington, A. C., and Adashi, E. Y. (1992). Endocrinology 130, 3092–3094.PubMedCrossRefGoogle Scholar
  34. 34.
    Rohan, R. M., Ricciarelli, E., Kiefer, M. C., Resnick, C. E., and Adashi, E. Y. (1993). Endocrinology 132, 2507–2512.PubMedCrossRefGoogle Scholar
  35. 35.
    Ui, M., Shimonaka, M., Shimasaki, S., and Ling, N. (1989). Endocrinology 25, 912–916.CrossRefGoogle Scholar
  36. 36.
    Shimasaki, S., Shimonaka, M., Ui, M., Inouye, S., Shibata, F., and Ling, N. (1990). J. Biol. Chem. 265, 2198–2202.PubMedGoogle Scholar
  37. 37.
    Bicsak, T. S., Shimonaka, M., Malkowski, M., and Ling, N. (1990). Endocrinology 126, 2184–2189.PubMedGoogle Scholar
  38. 38.
    Bicsak, T. S., Long, N., and DePaolo, L. V. (1991). Biol. Reprod. 44, 599–603.PubMedCrossRefGoogle Scholar
  39. 39.
    Shimasaki, S., Murakami, K., Morita, Y., and Erickson, G. F. (1995). Frontiers in endocrinology. Serono Symposium, Elsevier, New York.Google Scholar
  40. 40.
    Erickson, G. F., Nakatani, A., Liu, X.-J., Shimasaki, S., and Ling, N. (1994). In: Molecular biology of the female reproductive system. Findlay, J. K. (ed.). Academic: New York.Google Scholar
  41. 41.
    Liu, X.-J., Malkowski, M., Guo, T.-L., Erickson, G. F., Shimasaki, S., and Ling, N. (1993). Endocrinology 132, 1176–1183.PubMedCrossRefGoogle Scholar
  42. 42.
    Erickson, G. F., Li, D., Sadkhanloo, R., Liu, X.-J., Shimasaki, S., and Ling, N. (1994). Endocrinology 134, 1365–1372.PubMedCrossRefGoogle Scholar
  43. 43.
    Erickson, G. F., Li, D., Weitsman, S. R., Shimasaki, S., Ling, N., and Magoffin, D. A. (1995). Endocrine 3, 525–531.Google Scholar
  44. 44.
    Yoshimura, Y., Aoki, N., Sueoka, K., Miyazarki, T., Kuji, N., Tanaka, M., and Kobayashi, T. J. (1996). Clin. Invest. 98(2), 308–316.CrossRefGoogle Scholar
  45. 45.
    Efstratiadis, A. (1994). In: Developmental endocrinology, frontiers in endocrinology, vol. 6. Sizonenko, P. C., Aubert, M. L., and Vassali, J. D. (eds.). Ares-Serono Symposia Publications.Google Scholar
  46. 46.
    Xia, P., Tekpetey, F. R., and Armstrong, D. T. (1994). Mol. Reprod. Dev. 38, 373–379.PubMedCrossRefGoogle Scholar
  47. 47.
    Brower, P. T. and Schultz, R. M. (1982). Dev. Biol. 90, 144–153.PubMedCrossRefGoogle Scholar
  48. 48.
    Moore, R. M. (1983). In: Current problems in germ cell differentiation. McLaren, A. and Wylie, C. C. (eds.). University Press: Cambridge, UK.Google Scholar
  49. 49.
    Adashi, E. Y., Resnick, C. E., Dercole, A. J., Svoboda, M. C., and Van Wyk, J. J. (1985). Endocr. Rev. 6(3), 400–420.PubMedGoogle Scholar
  50. 50.
    Armstrong, D. T., Xia, P., de Gannes, G., Tekpetey, F. R., and Khamsi, F. (1996). Biol. Reprod. 54, 331–338.PubMedCrossRefGoogle Scholar
  51. 51.
    Khamsi, F. and Armstrong, D. T. (1997). Biol. Reprod. 57, 684–688.PubMedCrossRefGoogle Scholar
  52. 52.
    Khamsi, F. and Roberge, S. (2001). Fertil. Steril. 75, 997–1002.PubMedCrossRefGoogle Scholar
  53. 53.
    Khamsi, F. and Roberge, S. (2001). J. Endocrinol. 170, 565–573.PubMedCrossRefGoogle Scholar
  54. 54.
    Francis, A. L., Ross, M., Ballard, F. J., Milner, S. J., Senn, E., McNeil, K. M., Wallace, J. C., King, R., and Wells, J. R. E. (1992). J. Mol. Endocrinol. 8, 213–230.PubMedCrossRefGoogle Scholar
  55. 55.
    Ballafd, F. J., Francis, A. L., Walton, P. E., Knowles, S. E., Owens, P. C., Read, L. C., and Tomas, F. M. (1993). Aust. J. Agric. Sci. 44, 567–577.CrossRefGoogle Scholar
  56. 56.
    Khamsi, F. and Roberge, S. (2000). Endocrine 12(1), 41–45.PubMedCrossRefGoogle Scholar
  57. 57.
    Khamsi, F., Roberge, S., and Wong, J. (2001). Endocrine 14(3), 175–180.PubMedCrossRefGoogle Scholar
  58. 58.
    Khainsi, F., Roberge, S., Lacanna, I., Wong, J., and Yavas, Y. (1999). Endocrine 10, 161–166.CrossRefGoogle Scholar

Copyright information

© Humana Press Inc 2001

Authors and Affiliations

  • F. Khamsi
    • 1
    • 2
    • 3
  • S. Roberge
    • 1
  • Y. Yavas
    • 1
  • I. C. Lacanna
    • 1
  • X. Zhu
    • 1
  • J. Wong
    • 1
    • 4
  1. 1.Toronto Fertility Sterility InstituteTorontoCanada
  2. 2.Division of Endocrinology and Metabolism, Toronto General HospitalUniversity Health NetworkCanada
  3. 3.Department of MedicineUniversity of TorontoCanada
  4. 4.Department of Obstetrics and GynaecologyUniversity of Toronto and Sunnybrook Health Science CentreTorontoCanada

Personalised recommendations