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Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactation

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Abstract

Since normal human pregnancy is characterized by normotension in the face of an increased renin-angiotensin-aldosterone system (RAAS), we evaluated the temporal pattern of urinary excretion of a novel vasodilator within this system, angiotensin-(1–7) (Ang-[1–7]), during the menstrual cycle, pregnancy, and lactation. The urinary profiles of Ang I, Ang II, human chorionic gonadotropin, 17β-estradiol, and progesterone were also determined. During the menstrual cycle, urinary Ang-(1–7) and Ang II remained stable (mean cycle value: 94.6±11.3 and 11.4±1.1 pmol/g of creatinine, respectively) in nine females. In 10 normal pregnant women, urinary Ang-(1–7) and Ang II increased throughout gestation, averaging 1499.8±310 and 224.4±58 pmol/g of creatinine, respectively (p<0.05) at wk 35 and falling during lactation to 394.0±95 and 65.7±20 pmol/g of creatinine (p<0.05), respectively. The Ang-(1–7)/Ang II ratio was unchanged in the different reproductive periods. During the menstrual cycle, Ang II and Ang-(1–7) correlated with 17β-estradiol and progesterone using multivariate analysis (r=0.31, p<0.001) and r=0.28, p<0.02, respectively). During gestation, 17β-estradiol and progesterone correlated with urinary Ang-(1–7) (r=0.48, p<0.001 and r=0.47, p<0.001, respectively) and Ang II (r=0.24, p<0.03 and r=0.25, p<0.03, respectively); by multiple regression, only Ang-(1–7) correlated with both steroids (r=0.49, p<0.001). The progressive rise of Ang-(1–7) throughout gestation, probably modulated by estrogen and progesterone, suggests a physiologic counterregulation within the RAAS.

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Authors and Affiliations

  1. Departamento de Nefrología, Pontificia Universidad Católica, Santiago, Chile

    Gloria Valdés

  2. Departamento de Obstetricia/Ginecología, Pontificia Universidad Católica, Santiago, Chile

    Alfredo M. Germain & Cecilia Berrios

  3. Departamento de Centro de Investigaciones Médicas, Pontificia Universidad Católica, Santiago, Chile

    Gloria Valdés, Alfredo M. Germain & Jenny Corthorn

  4. Departmento de Unidad de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica, Santiago, Chile

    Arnaldo C. Foradori

  5. Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Medical Center Boulevard, 27157-1032, Winston-Salem, NC

    Carlos M. Ferrario &  K. Bridget Brosnihan

Authors
  1. Gloria Valdés
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  2. Alfredo M. Germain
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  3. Jenny Corthorn
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  4. Cecilia Berrios
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  5. Arnaldo C. Foradori
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  6. Carlos M. Ferrario
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  7. K. Bridget Brosnihan
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Correspondence to K. Bridget Brosnihan.

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Valdés, G., Germain, A.M., Corthorn, J. et al. Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactation. Endocr 16, 117–122 (2001). https://doi.org/10.1385/ENDO:16:2:117

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  • DOI: https://doi.org/10.1385/ENDO:16:2:117

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