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Long-term therapy with recombinant human growth hormone (Saizen®) in children with idiopathic and organic growth hormone deficiency

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Abstract

In an open-label study, 69 children with organic or idiopathic growth hormone deficiency (GHD) were treated with recombinant human growth hormone (Saizen®) for an average of 64.4 mo, with treatment periods as long as 140.9 mo. Auxologic measurements, including height velocity, height standard deviation score, and bone age, were made on a regular basis. The data suggest that long-term treatment with Saizen in children with GHD results in a positive catch-up growth response and proportionate changes in bone age vs height age during treatment. In addition, long-term Saizen therapy was well tolerated, with the majority of adverse events related to common childhood disorders or existing baseline medical conditions and not to study treatment. There were no significant changes in laboratory safety data or vital signs, and no positive antibody tests for Saizen.

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Authors and Affiliations

  1. Division of Pediatric Endocrinology, Diabetes and Metabolism, Departments of Pediatrics and Pharmacology and Therapeutics, University of South Florida, Tampa

    Barry B. Bercu

  2. Serono Laboratories, Norwell, MA

    F. T. Murray, Louis S. O'Dea, J. Brentzel, B. Hanson & H. Landy

  3. Department of Pediatrics, University of California, Los Angeles

    S. D. Frasier

  4. School of Medicine, Richmond, VA

    C. Rudlin

  5. Department 6900, All Children's Hospital, 801 Sixth Street South, 33701, St. Petersburg, FL

    Barry B. Bercu

Authors
  1. Barry B. Bercu
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  2. F. T. Murray
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  3. S. D. Frasier
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  4. C. Rudlin
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  5. Louis S. O'Dea
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  6. J. Brentzel
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  7. B. Hanson
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  8. H. Landy
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Correspondence to Barry B. Bercu.

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Bercu, B.B., Murray, F.T., Frasier, S.D. et al. Long-term therapy with recombinant human growth hormone (Saizen®) in children with idiopathic and organic growth hormone deficiency. Endocr 15, 43–49 (2001). https://doi.org/10.1385/ENDO:15:1:043

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