Skip to main content
SpringerLink
Log in

Steroid hormone receptors in target cell membranes

  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Numerous reports of rapid steroid hormone effects in diverse cell types cannot be explained by the generally prevailing theory that centers on the activity of hormone receptors located exclusively in the nucleus. Cell membrane forms of steroid hormone receptors coupled to intracellular signaling pathways may also play an important role in hormone action. Membrane-initiated signals appear to be the primary response of the target cell to steroid hormones and may be prerequisite to subsequent genomic activation. Recent dramatic advances in this area have intensified efforts to delineate the nature and biologic roles of all receptor molecules that function in steroid hormone-signaling pathways. This work has profound implications for our understanding of the physiology and pathophysiology of hormone actions in responsive cells and may lead to development of nvoel approaches for the treatment of many cell proliferative, metabolic, inflammatory, reproductive, cardiovascular, and neurologic defects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Evans, R. M. (1988). Science 240, 889–895.

    Article  PubMed  CAS  Google Scholar 

  2. Szego, C. M. (1984). Life Sci. 35, 2383–2396.

    Article  PubMed  CAS  Google Scholar 

  3. Szego, C. M. and Pietras, R. J. (1981). In: Biochemical actions of hormones, vol. 8. Litwack, G. (ed.). Academic; New York.

    Google Scholar 

  4. Moss, R. L., Gu, Q., and Wong, M. (1997). Recent Prog. Horm. Res. 52, 33–70.

    PubMed  CAS  Google Scholar 

  5. Nemere, I. and Farach-Carson, M. (1998). Biochem. Biophys. Res. Commun. 248, 443–449.

    Article  PubMed  CAS  Google Scholar 

  6. Christ, M., Haseroth, K., Falkenstein, E., and Wehling, M. (1999). Vitam Horm. 57, 325–373.

    PubMed  CAS  Google Scholar 

  7. Watson, C. S. and Gametchu, B. (1999). Proc. Soc. Exp. Biol. Med. 220, 9–19.

    Article  PubMed  CAS  Google Scholar 

  8. Milgrom, E., Atger, M., and Baulieu, E. E. (1973). Biochim. Biophys. Acta 320, 267–283.

    PubMed  CAS  Google Scholar 

  9. Pietras, R. J. and Szego, C. M. (1975). Nature 253, 357–359.

    Article  PubMed  CAS  Google Scholar 

  10. Improta-Brears, T., Whorton, A. R., Codazzi, F., York, J. D., Meyer, T., and McDonnell, D. P. (1999). Proc. Natl. Acad. Sci. USA 96, 4686–4691/

    Article  PubMed  CAS  Google Scholar 

  11. Szego, C. M. and Davis, J. S. (1967). Proc. Natl. Acad. Sci. USA 58, 1711–1718.

    Article  PubMed  CAS  Google Scholar 

  12. Aronica, S., Kraus, W., and Katzenellenbogen, B (1994). Proc. Natl. Acad. Sci. USA 91, 8517–8521.

    Article  PubMed  CAS  Google Scholar 

  13. Endoh, H., Sasaki, H., Maruyama, K., Takeyama, K., Waga, I., Shimizu, T., Kato, S., and Kawashima, H. (1997). Biochem. Biophys. Res. Commun. 235, 99–102.

    Article  PubMed  CAS  Google Scholar 

  14. Le Mellay, V., Grosse, B., and Lieberherr, M. (1997). J. Biol. Chem. 272, 11,902–11,907.

    Article  CAS  Google Scholar 

  15. Ramirez, V. D. and Zheng, J. (1996). Front. Neuroendocrinol. 17, 402–439.

    Article  PubMed  CAS  Google Scholar 

  16. Pietras, R. J. and Szego, C. M. (1977). Nature 265, 69–72.

    Article  PubMed  CAS  Google Scholar 

  17. Pietras, R. J. and Szego, C. M. (1979). J. Cell. Physiol. 98, 145–159.

    Article  PubMed  CAS  Google Scholar 

  18. Pietras, R. J. and Szego, C. M. (1980). Biochem. J. 191, 743–760.

    PubMed  CAS  Google Scholar 

  19. Selye, H. (1942). Endocrinology 30, 437–453.

    CAS  Google Scholar 

  20. Dufy, B., Partouche, C., Poulain, D., Dufy-Barbe, L., and Vincent, J. (1976). Neuroendocrinology 22, 38–47.

    PubMed  CAS  Google Scholar 

  21. Kelly, M. J., Moss, R. L., and Dudley, C. A. (1977). Exp. Brain Res. 30, 53–64.

    PubMed  CAS  Google Scholar 

  22. Mendelsohn, M. and Karas, R. (1999). N. Engl. J. Med. 340, 1801–1811.

    Article  PubMed  CAS  Google Scholar 

  23. Chen, Z., Yuhanna, I. S., Galcheva-Gargova, Z., Karas, R. H., Mendelsohn, M., and Shaul, P. (1999). J. Clin. Invest. 103, 401–406.

    PubMed  CAS  Google Scholar 

  24. Kim, H. P., Lee, J. Y., Jeong, J. K., Bae, S. W., Lee, H. K., and Jo, I. (1999). Biochem. Biophys. Res. Commun. 263, 257–262.

    Article  PubMed  CAS  Google Scholar 

  25. Razandi, M., Pedram, A., Greene, G., and Levin, E. (1999). Mol. Endocrinol. 13, 307–319.

    Article  PubMed  CAS  Google Scholar 

  26. Berthois, Y., Pourreau-Schneider, N., Gandilhon, P., Mittre, H., Tubiana, N., and Martin, P. M. (1986). J. Steroid Biochem. 25, 963–972.

    Article  PubMed  CAS  Google Scholar 

  27. Stevis, P., Deecher, D., Suhadolnik, L., Mallis, L., and Frail, D. (1999). Endocrinology 140, 5455–5458.

    Article  PubMed  CAS  Google Scholar 

  28. McEwen, B. S. (1991). Trends Pharmacol. Sci. 12, 141–147.

    Article  PubMed  CAS  Google Scholar 

  29. Godeau, J., Schorderet-Slatkine, S., Hubert, P., and Baulieu, E. E. (1978). Proc. Natl. Acad. Sci. USA 75, 2353–2357.

    Article  PubMed  CAS  Google Scholar 

  30. Kostellow, A. B., Weinstein, S. P., and Morrill, G. A. (1982). Biochim. Biophys. Acta 720, 356–363.

    Article  PubMed  CAS  Google Scholar 

  31. Sadler, S. and Maller, J. (1982). J. Biol. Chem. 257, 355–361.

    PubMed  CAS  Google Scholar 

  32. Morrill, G. A. and Kostellow, A. B. (1999). Steroids 64, 157–167.

    Article  PubMed  CAS  Google Scholar 

  33. Blakemore, P., Neulen, J., Lattanzio, F., and Beebe, S. (1991). J. Biol. Chem. 266, 18,655–18,659.

    Google Scholar 

  34. Meizel, S. and Turner, K. (1991). Mol. Cell. Endocrinol. 77, 1–5.

    Article  Google Scholar 

  35. Sabeur, K., Edwards, D., and Meizel, S. (1996). Biol. Reprod. 54, 993–1001.

    Article  PubMed  CAS  Google Scholar 

  36. Gorczynska, E. and Handelsman, D. (1995). Endocrinology 136, 2052–2059.

    Article  PubMed  CAS  Google Scholar 

  37. Peterziel, H., Mink, S., Schonert, A., Becker, M., Klocker, H., and Cato, A. C. (1999). Oncogene 18, 6322–6329.

    Article  PubMed  CAS  Google Scholar 

  38. Perusquia, M. and Villalon, C. (1999). Eur. J. Pharmacol. 371, 169–178.

    Article  PubMed  CAS  Google Scholar 

  39. Lieberherr, M. and Grosse, B. (1994). J. Biol. Chem. 269, 7217–7223.

    PubMed  CAS  Google Scholar 

  40. Benten, W., Lieberherr, M., Stamm, O., Wrehlke, C., Guo, Z., and Wunderlich, F. (1999). Mol. Biol. Cell 10, 3113–3123.

    PubMed  CAS  Google Scholar 

  41. Hummerick, H. and Soboll, S. (1989). Biochem. J. 258, 363–367.

    Google Scholar 

  42. Segal, J. (1989). Endocrinology 124, 2755–2764.

    PubMed  CAS  Google Scholar 

  43. Segal, J., Masalha, S., Schwalb, H., Merin, G., Borman, J. B., and Uretzky, G. (1996). J. Endocrinol. 149, 73–80.

    Article  PubMed  CAS  Google Scholar 

  44. Davis, P. and Davis, F. (1996). Thyroid 6, 497–504.

    PubMed  CAS  Google Scholar 

  45. Lakatos, P. and Stern, P. (1991). Acta Endocrinol. (Copenh.) 125, 603–608.

    CAS  Google Scholar 

  46. Roussel, J. P., Grazzini, E., Zumbihl, R., Rodriguez, E., and Astier, H. (1995). Eur. J. Pharmacol. 289, 205–215.

    Article  PubMed  CAS  Google Scholar 

  47. Alderson, R., Pastan, I., and Cheng, S.-Y. (1985). Endocrinology 116, 2621–2630.

    PubMed  CAS  Google Scholar 

  48. Pontecorvi, A., Lakshmanan, M., and Robbins, J. (1987). Endocrinology 121, 2145–2152.

    PubMed  CAS  Google Scholar 

  49. Estupina, C., Belmar, J., Tapia-Arancibia, L., Astier, H., and Arancibia, S. (1997). Exp. Brain Res. 113, 337–342.

    Article  PubMed  CAS  Google Scholar 

  50. Towle, A. C. and Sze, P. Y. (1983). J. Steroid Biochem. 1, 135–143.

    Article  Google Scholar 

  51. Orchinik, M., Murray, T., and Moore, F. (1991). Science 252, 1848–1851.

    Article  PubMed  CAS  Google Scholar 

  52. Andres, M., Marino, A., Macarulla, J., and Trueba, M. (1997). Cell. Mol. Life Sci. 53, 673–680.

    Article  PubMed  CAS  Google Scholar 

  53. Gametchu, B. (1987). Science 236, 456–461.

    Article  PubMed  CAS  Google Scholar 

  54. Gametchu, B., Watson, C. S., and Wu, S. (1993). FASEB J. 7, 1283–1292.

    PubMed  CAS  Google Scholar 

  55. Powell, C., Watson, C., and Gametchu, B. (1999). Endocrine 10, 271–280.

    PubMed  CAS  Google Scholar 

  56. Chen, F., Watson, C., and Gametchu, B. (1999). J. Cell. Biochem. 74, 418–429.

    Article  PubMed  CAS  Google Scholar 

  57. Ebata, S., Muto, S., Okada, K., Nemoto, J., Amemiya, M., Saito, T., and Asamo, Y. (1999). Kidney Int. 56, 1400–1412.

    Article  PubMed  CAS  Google Scholar 

  58. Doolan, C. M. and Harvey, B. J. (1996). J. Biol. Chem. 271, 8763–8767.

    Article  PubMed  CAS  Google Scholar 

  59. Kolbel, F. and Schreiber, A. (1996). Mol. Cell. Biochem. 160/161, 111–115.

    Article  CAS  Google Scholar 

  60. Doris, P., Hayward-Lester, A., Bourne, D., and Stocco, D. (1996). Endocrinology 137, 533–539.

    Article  PubMed  CAS  Google Scholar 

  61. LaBella, F. and Templeton, J. (1998). Clin. Exp. Hypertens. 20, 601–609.

    PubMed  CAS  Google Scholar 

  62. Huang, L., Li, H., and Xie, Z. (1997). J. Mol. Cell. Cardiol. 29, 429–437.

    Article  PubMed  CAS  Google Scholar 

  63. Caffrey, J. M. and Farach-Carson, M. C. (1989). J. Biol. Chem. 264, 20,265–20,274.

    CAS  Google Scholar 

  64. Boyan, B. D., Sylvia, V. L., Dean, D. D., Pedrozo, H., Del Toro, F., Nemere, I., Posner, G. H., and Schwartz Z. (1999). Steroids 64, 129–136.

    Article  PubMed  CAS  Google Scholar 

  65. Nemere, I., Schwartz, Z., Pedrozo, H., Sylvia, V. L., Dean, D. D., and Boyan, B. D. (1998). J. Bone Miner. Res. 13, 1353–1359.

    Article  PubMed  CAS  Google Scholar 

  66. Jespersen, B., Randlov, A., Abrahamsen, J., Fogh-Andersen, N., Olsen, N. V., and Kanstrup, I. L. (1998). Am. J. Hypertens. 11, 659–666.

    Article  PubMed  CAS  Google Scholar 

  67. Berry, D. M. and Meckling-Gill, K. A. (1999). Endocrinology 140, 4779–4788.

    Article  PubMed  CAS  Google Scholar 

  68. Kajikawa, M., Ishida, H., Fujimoto, S., Mukai, E., Nishimura, M., Fujita, J., Tsuura, Y., Okamoto, Y., Norman, A. W., and Seino, Y. (1999). Endocrinology 140, 4706–4712.

    Article  PubMed  CAS  Google Scholar 

  69. Nemere, I. (1999). J. Bone Miner. Res. 14, 1543–1549.

    Article  PubMed  CAS  Google Scholar 

  70. Bianchi, M. L., Ardissino, G. L., Schmitt, C. P., Dacco, V., Barletta, L., Claris-Appiani, A., and Mehls, O. (1999). J. Bone Miner. Res. 14, 1789–1795.

    Article  PubMed  CAS  Google Scholar 

  71. O'Connell, M., Chua, R., Hoyos, B., Buck, J., Chen, Y., Derguini, F., and Hammerling, U. (1996). J. Exp. Med. 184, 549–555.

    Article  PubMed  Google Scholar 

  72. Sundaram, M., Sivaprasadarao, A., DeSousa, M. M., and Findlay, J. B. (1998). J. Biol. Chem. 273, 3336–3342.

    Article  PubMed  CAS  Google Scholar 

  73. Christensen, E. I., Moskaug, J. O., Vorum, H., Jacobsen, C., Gundersen, T. E., Nykjaer, A., Blomhoff, R., Willnow, T. E., and Moestrup, S. K. (1999). J. Am. Soc. Nephrol. 10, 685–695.

    PubMed  CAS  Google Scholar 

  74. Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E. I., and Willnow, T. E. (1999). Cell 96, 507–515.

    Article  PubMed  CAS  Google Scholar 

  75. Kang, J., Li, Y., and Leaf, A. (1997). Proc. Natl. Acad. Sci. USA 94, 13,671–13,676.

    CAS  Google Scholar 

  76. Pietras, R. J. and Szego, C. M. (1979). J. Steroid Biochem. 11, 1471–1483.

    Article  PubMed  CAS  Google Scholar 

  77. Monje, P. and Boland, R. (1999). Mol. Cell. Endocrinol. 147, 75–84.

    Article  PubMed  CAS  Google Scholar 

  78. Pappas, T., Gametchu, B., and Watson, C. (1995). FASEB J. 9, 404–410.

    PubMed  CAS  Google Scholar 

  79. Russell, K. S., Haynes, M., Sinha, D., Clerisme, E., and Bender, J. R. (2000). Proc. Natl. Acad. Sci. USA 97, 5930–5935.

    Article  PubMed  CAS  Google Scholar 

  80. Norfleet, A., Thomas, M., Gametchu, B., and Watson, C. (1999). Endocrinology 140, 3805–3814.

    Article  PubMed  CAS  Google Scholar 

  81. Zheng, J. and Ramirez, V. (1997). J. Steroid Biochem. Mol. Biol. 62, 327–336.

    Article  PubMed  CAS  Google Scholar 

  82. Rosner, W., Hryb, D. J., Khan, M., Nakhla, A. M., and Romas, N. A. (1999). Steroids 64, 100–106.

    Article  PubMed  CAS  Google Scholar 

  83. Szego, C. and Roberts, S. (1946). Proc. Soc. Exp. Biol. Med. 61, 161–164.

    CAS  Google Scholar 

  84. Meyer, C., Schmid, R., Scriba, P., and Wehling, M. (1996). Eur. J. Biochem. 239, 726–731.

    Article  PubMed  CAS  Google Scholar 

  85. Falkenstein E., Heck, M., Gerdes, D., Grube, D., Christ, M., Weigel, M., Buddhikot, M., Meizel, S., and Wehling, M. (1999). Endocrinology 140, 5999–6002.

    Article  PubMed  CAS  Google Scholar 

  86. Eisen, C., Meyer, C., Christ, M., Theisen, K., and Wehling, M. (1994). Cell. Mol. Biol. 40, 351–358.

    PubMed  CAS  Google Scholar 

  87. Baran, D. T., Quail, J. M., Ray, R., Leszyk, J., and Honeyman, T. (2000). J. Cell. Biochem. 78, 34–46.

    Article  PubMed  CAS  Google Scholar 

  88. Nemere, I., Dormanen, M., Hammond, M., Okamura, W., and Norman, A. (1994). J. Biol. Chem. 261, 16,106–16,114.

    Google Scholar 

  89. Nemere, I., Ray, R., and McManus, W. (2000). Am. J. Physiol. Endocr. Metab. 278, E1104-E1114.

    CAS  Google Scholar 

  90. Matsuda, S., Kadowaki, Y., Ichino, M., Akiyama, T., Toyoshima, K., and Yamamoto, T. (1993). Proc. Natl. Acad. Sci. USA 90, 10,803–10,808.

    CAS  Google Scholar 

  91. Grazzini, E., Guillon, G., Mouillac, B., and Zingg, H. H. (1998). Nature 392, 509–512.

    Article  PubMed  CAS  Google Scholar 

  92. Mihalek, R. M., Banerjee, P. K., Korpi, E. R., et al. (1999). Proc. Natl. Acad. Sci. USA 96, 12,905–12,910.

    Article  CAS  Google Scholar 

  93. Valverde, M., Rojas, P., Amigo, J., Cosmelli, D., Orio, P., Bahamonde, M. I., Mann, G. E., Vergara, C., Latorre, R. (1999). Science 285, 1929–1931.

    Article  PubMed  CAS  Google Scholar 

  94. Gu, Q., Korach, K., and Moss, R. (1999). Endocrinology 140, 660–666.

    Article  PubMed  CAS  Google Scholar 

  95. Couse, J., Curtis, S. W., Washburn, T. F., Lindzey, J., Golding, T. S., Lubahn, D. B., Smithies, O., and Korach, K. S. (1995). Mol. Endocrinol. 9, 1441–1454.

    Article  PubMed  CAS  Google Scholar 

  96. Kuiper, G. G., Enmark, E., Pelto-Huikko, E., Nilsson, S., and Gustafsson, J. A. (1996). Proc. Natl. Acad. Sci. USA 93, 5925–5930.

    Article  PubMed  CAS  Google Scholar 

  97. Lubahn, D. B., Mouger, J., Golding, T., Couse, J., Kotach, K., and Smithies, O. (1993). Proc. Natl. Acad. Sci. USA 90, 11,162–11,166.

    Article  CAS  Google Scholar 

  98. Pietras, R. J., Arboleda, J., Reese, D. M., Wongwipation-Pegram, M. D., Ramos, L., Gorman, C. M., Parker, M. G., Sliwkowski, M. X., and Slamon, D. J. (1995). Oncogene 10, 2435–2446.

    PubMed  CAS  Google Scholar 

  99. Civelli, O. (1995). J. Recept. Signal Transduct. Res. 15, 161–172.

    PubMed  CAS  Google Scholar 

  100. Schneider, S., Wunsch, S., Schwab, A., and Obetleithner, H. (1996). Mol. Cell. Endocrinol. 116, 73–79.

    Article  PubMed  CAS  Google Scholar 

  101. Szego, C. M. (1994). Endocrinol. 2, 1079–1093.

    CAS  Google Scholar 

  102. Ehrlich, P. (1900). In: The collected papers of Paul Ehrlich. vol. II (1957), Himmelweit, F. (ed.) Pergamon: Oxford.

    Google Scholar 

  103. Williams, M. and Baba, W. (1967). J. Endocrinol. 39, 543–554.

    PubMed  CAS  Google Scholar 

  104. Pietras, R. J. and Szego, C. M. (1984). Biochem. Biophys. Res. Commun. 123, 84–90.

    Article  PubMed  CAS  Google Scholar 

  105. Szego, C. M. and Pietras, R. J. (1984). Int. Rev. Cytol. 88, 1–302.

    Article  PubMed  CAS  Google Scholar 

  106. Szego, C. M., Sjöstrand, B. M., Seeler, B. J., Baumer, J., and Sjöstrand, F. S. (1988). Am. J. Physiol. 254, (Endocrinol. Metab. 17), E775-E785.

    PubMed  CAS  Google Scholar 

  107. Chen, Y.-Z. and Qui, J. (1999). Mol. Cell Biol. Res. Commun. 2, 145–149.

    Article  PubMed  CAS  Google Scholar 

  108. Suyemitsu, T. and Terayama, H. (1975). Endocrinology 96, 1499–1508.

    Article  PubMed  CAS  Google Scholar 

  109. Nemere, I. and Szego, C. M. (1981). Endocrinology 108, 1450–1462.

    PubMed  CAS  Google Scholar 

  110. Pourreau-Schneider, N., Berthois, Y., Gaudilhon, JP, Cau, P., and Martin, P. M. (1986). Mol. Cell. Endocrinol. 48, 77–88.

    Article  PubMed  CAS  Google Scholar 

  111. Wehling, M., Kasmayr, J., and Theisen, K. (1991). Am. J. Physiol. 260, E719-E726.

    PubMed  CAS  Google Scholar 

  112. Rambo, C. O. and Szego, C. M. (1983). J. Cell Biol. 97, 679–685.

    Article  PubMed  CAS  Google Scholar 

  113. Simoncini, T., Hafezi-Moghadam, A., Brazil, D., Ley, K., Chin, W., Liao, J. (2000). Nature 407, 538–541.

    Article  PubMed  CAS  Google Scholar 

  114. Watters, J. J., Chun, T.-Y., Kim, Y.-N., Bertics, P. J., and Gorski, J. (2000). Mol. Endocrinol. 14, 1872–1881.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, 11-934 Factor Building, 90095-1678, Los Angeles, CA

    Richard J. Pietras

  2. Jonsson Comprehensive Cancer Center, University of California School of Medicine, Los Angeles, CA

    Richard J. Pietras

  3. Department of Nutrition & Food Science, Utah State University, Logan, UT

    Ilka Nemere

  4. Biotechnology Center, Utah State University, Logan, UT

    Ilka Nemere

  5. Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA

    Clara M. Szego

  6. Molecular Biology Institute, University of California, Los Angeles, CA

    Clara M. Szego

  7. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA

    Clara M. Szego

Authors
  1. Richard J. Pietras
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ilka Nemere
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Clara M. Szego
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard J. Pietras.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pietras, R.J., Nemere, I. & Szego, C.M. Steroid hormone receptors in target cell membranes. Endocr 14, 417–427 (2001). https://doi.org/10.1385/ENDO:14:3:417

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/ENDO:14:3:417

Key words

Search

Navigation