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Genetics, chemistry, and function of the IGF/IGFBP system

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Abbreviations

IGF:

insulin-like growth factor

IGFBP:

insulin-like growth factor binding protein

IGFBP-RP:

insulin-like growth factor binding protein related proteins

BP-Pr:

insulin-like growth factor binding protein proteases

IGF-I-R:

type 1 IGF receptor

References

  1. Baxter, R. C. (1994), Horm. Res. 42, 140–144.

    PubMed  CAS  Google Scholar 

  2. Twigg, S. M., Baxter, R. C. (1998), J. Biol. Chem. 273, 6074–6079.

    Article  PubMed  CAS  Google Scholar 

  3. Khosravi, M. J., Diamandi, A., Mistry, J., Krishna, R. G., Khare, A. (1997), J. Clin. Endocrinol. Metab. 82, 3944–3951.

    Article  PubMed  CAS  Google Scholar 

  4. Hasegawa, T., Cohen, P., and Rosenfeld, R. G. (1995), Growth Reg. 151–159.

  5. Cohen, P., Rosenfeld, R. G. (1995). In: Human Growth Hormone, Basic and Scientific Aspects. Rosenbloom, A. L. (ed.). CRC Press: Boca Raton, FL, pp. 43–58.

    Google Scholar 

  6. Arany, E., Afford, S., Strain, A. J., Winwood, P. J., Arthur, M. J., and Hill, D. J. (1994), J. Clin. Endocrinol. Metab. 79, 1871–1876.

    Article  PubMed  CAS  Google Scholar 

  7. Chin, E., Zhou, J., Dai, J., Baxter, R. C., and Bondy, C. A. (1994). Endocrinology 134, 2498–2504.

    Article  PubMed  CAS  Google Scholar 

  8. Villafuerte, B. C., Koop, B. L., Pao, C. I., Gu, L., Birdsong, G. G., and Phillips, L. S. (1994), Endocrinology 134, 2044–2050.

    Article  PubMed  CAS  Google Scholar 

  9. Rosenfeld, R. G., Pham, H., Cohen, P., Fielder, P., Gargosky, S. E., Müller, H., Nonoshita, L., and Oh, Y. (1994), Acta Pediatr. 339, 154–158.

    Google Scholar 

  10. Baxter, R. C., Binoux, M. A., Clemmons, D. R., Conover, C. A., Drop, S. L., Holly, J. M., Mohan, S., Oh, Y., Rosenfeld, R. G. (1998), Endocrinology 139, 4036.

    Article  PubMed  CAS  Google Scholar 

  11. Cohen, P., Fielder, P. J., Hasegawa, Y., Frisch, H., Giudice, L. C., and Rosenfeld, R. G. (1991). Acta Endocrinol. 124, 74–85.

    PubMed  CAS  Google Scholar 

  12. Holly, J. M. P. and Martin, J. L. (1994), Growth Reg. 4, 20–30.

    CAS  Google Scholar 

  13. Lamson, G., Giudice, L. C., and Rosenfeld, R. G. (1991). Growth Factors, 5, 19–28.

    PubMed  CAS  Google Scholar 

  14. Underwood, L. E., Thissen, J. P., Lemozy, S., Ketelsegers, J. M., and Clemmons, D. R. (1994), Horm. Res. 42, 145–151.

    PubMed  CAS  Google Scholar 

  15. Katz, L. E. L., Rosenfeld, R. G., and Cohen, P. (1995), Endocrinologist 5, 36–43.

    Google Scholar 

  16. Smith, W. J., Underwood, L. E., and Clemmons, D. R. (1995). J. Clin. Endocrinol. Metab. 80, 443–449.

    Article  PubMed  CAS  Google Scholar 

  17. Baxter, R. C., Saunders, H. (1992), J. Endocrinol. 134, 133–139.

    PubMed  CAS  Google Scholar 

  18. Mohan, S., Farley, J. R., and Baylink, D. J. (1995), Prog. Growth Factor Res. 6, 465–473.

    Article  PubMed  CAS  Google Scholar 

  19. Mohan, S., Libanati, C., Dony, C., Lang, K., Srinivasan, N., and Baylink, D. J. (1995). J. Clin. Endocrinol. Metab. 80, 2638–2645.

    Article  PubMed  CAS  Google Scholar 

  20. Thoren, M., Hilding, A., Brismar, T., Magnusson, P., Degerblat, M., Larsson, L., Saaf, M., Baylink, D. J., and Mohan, S. (1983), J. Bone Min. Res. 13, 891–899.

    Article  Google Scholar 

  21. Tricoli, J. V., Rall, L. B., Scott, J., Bell, G. I., and Shows, T. B. (1984), Nature 310, 784–786.

    Article  PubMed  CAS  Google Scholar 

  22. Daughaday, W. H., and Rotwein, P. (1989), Endocr. Rev. 10, 68–91.

    PubMed  CAS  Google Scholar 

  23. Collett-Solberg, P. and Cohen, P. (1996), Endocrinol. Metabol. Clin. NA. 25, 591–614.

    Article  CAS  Google Scholar 

  24. Conover, C. A., Clarkson, J. T., and Bale, L. K. (1995), Endocrinology, 136, 1403–1410.

    Article  PubMed  CAS  Google Scholar 

  25. Cohen, P. and Rosefeld, R. G. (1994). Curr. Opin. Ped. 6, 462–467.

    Article  CAS  Google Scholar 

  26. Jones, J. I. and Clemmons, D. R. (1995), Endocr. Rev. 16, 3–34.

    Article  PubMed  CAS  Google Scholar 

  27. Liu, J-P., Baker, J., Perkins, A. S., Robertson, E. J., and Efstratiadis, A. (1993). Cell 75, 59–72.

    PubMed  CAS  Google Scholar 

  28. Baker, J., Liu, J.-P., Robertson, E. J., and Efstratiadis, A. (1993), Cell 75, 73–82.

    PubMed  CAS  Google Scholar 

  29. Woods, K. A., Camacho-Hubner, C., Savage, M. O., and Clark, A. J. L. (1996), N. Engl. J. Med. 335, 1363–1367.

    Article  PubMed  CAS  Google Scholar 

  30. Katz, L. E. L., Satin-Smith, M., Collett-Solberg, P., Thornton, P. S., Baker, L., Stanley, C. A., Cohen, P. (1997), J. Pediatr. 131, 193–199.

    Article  CAS  Google Scholar 

  31. Katz, L. E. L., Stain-Smith, M., Collett-Solberg, P., Baker, L., Stanley, C. A., and Cohen, P. (1998). J. Clin. Endocrinol. Metab. 83, 4426–4430.

    Article  PubMed  CAS  Google Scholar 

  32. Hirschberg, R. and Kopple, J. D. (1989). J. Clin. Invest. 83, 326–330.

    PubMed  CAS  Google Scholar 

  33. Hirschberg, R., Kopple, J. D., Blantz, R. C., and Tucker, B. J. (1991), J. Clin. Invest. 87, 1200–1206.

    PubMed  CAS  Google Scholar 

  34. Sandra, A., Boes, M., Dake, B. L., Stokes, J. B., and Bar, R. S. (1998), Am. J. Physiol. 275, E32-E37.

    PubMed  CAS  Google Scholar 

  35. Sugimoto, T., Nishiyama, K., Kuribayashi, F., and Chihara, K. (1997). J. Bone Min. Res. 12, 1272–1279.

    Article  CAS  Google Scholar 

  36. Werner, H. and LeRoith, D. (1996). Cancer Res. 68, 183–223.

    CAS  Google Scholar 

  37. Chan, J. M., Stampfer, M. J., Giovanucci, E., Gann, P. H., Jing Ma, Wilkinson, P., Hennekens, C. H., and Pollak, M. (1998). Science 279, 563–566.

    Article  PubMed  CAS  Google Scholar 

  38. DeChiara, T. M., Efstratiadis, A., and Robertson, E. J. (1990). Nature 345, 78–80.

    Article  PubMed  CAS  Google Scholar 

  39. Boulle, N., Logie, A., Gicquel, C., Perin, L., and Le Bouc, Y. (1998). J. Clin. Endocrinol. Metab. 83, 1713–1720.

    Article  PubMed  CAS  Google Scholar 

  40. Shimasaki, S. and Ling, N. (1991). Prog. Growth Factor Res. 3, 243–266.

    Article  PubMed  CAS  Google Scholar 

  41. Hong, Y. S., Kim, S. P., Bhattacharya, A., Pratt, D. R., Hong, W. K., and Tainsky, M. A. (1995), Gene 159, 209–214.

    Article  PubMed  CAS  Google Scholar 

  42. Matsui, T., Hirai, M.. Hirano, M., and Kurosawa, Y. (1993). FEBS Lett. 336, 107–110.

    Article  PubMed  CAS  Google Scholar 

  43. Allander, S. V., Bajalica, S., Larsson, C., Luthman, H., Powell, D. R., Stern, I., Weber, G., Zazzi, H., and Ehrenborg, E. (1993). Growth Reg. 3, 3–5.

    CAS  Google Scholar 

  44. Kou, K., Jenkins, N. A., Gilbert, D. J., et al. (1994). Genomics 20, 412–418.

    Article  PubMed  CAS  Google Scholar 

  45. Ruoslathi, E. and Pierschlaber, M. D. (1987). Science 238, 491–497.

    Article  Google Scholar 

  46. Clemmons, D. R. (1994). In: Current Directions in Insulin-Like Growth Factor Research. LeRoith, D. and Raizada, M. K. (eds). Plenum Press: New York.

    Google Scholar 

  47. Coverley, J. A. and Baxter, R. C. (1997). Mol. Cell. Endocrinol. 128, 1–5.

    Article  PubMed  CAS  Google Scholar 

  48. Batch, J. A., Baxter, R. C., and Werther, G. (1991). J. Clin. Endocrinol. Metab. 73, 964–968.

    PubMed  CAS  Google Scholar 

  49. Counts, D. R., Gwirtsman, H., Carlsson, L. M., Lesem, M., and Cutler, G. B., Jr. (1992). J. Clin. Endocrinol. Metab. 75, 762–767.

    Article  PubMed  CAS  Google Scholar 

  50. Strasser-Vogel, B., Blum, W. F., Past, R., Kessler, U., Hoeflich, A., Meiler, B., and Kiess, W. (1995). J. Clin. Endocrinol. Metab. 80, 1207–1213.

    Article  PubMed  CAS  Google Scholar 

  51. Unterman, T. G., Oehler, D. T., Murphy, L. J., and Lacson, R. G. (1991). Endocrinology 128, 2693–2701.

    PubMed  CAS  Google Scholar 

  52. Conover, C. A., Divertie, G. D., and Lee, P. D. (1993). Acta Endocrinol. 128, 140–143.

    PubMed  CAS  Google Scholar 

  53. Lee, P. D. K., Conover, C. A., and Powell, D. R. (1993). Proc. Soc. Exp. Biol. Med. 204, 4–29.

    PubMed  CAS  Google Scholar 

  54. Price, W. A., Stiles, A. D., Moats-Staats, B. M., and D'Ercole, A. J. (1992). Endocrinology 130, 1424–1432.

    Article  PubMed  CAS  Google Scholar 

  55. Conover, C. A., Lee, P. D., Riggs, B. L., and Powell, D. R. (1996). Endocrinology 137, 3295–3301.

    Article  PubMed  CAS  Google Scholar 

  56. Samstein, B., Hoimes, M. L., Fan, J., Frost, R. A., Gelato, M. C., and Lang, C. H. (1996), Biochem. Biophys. Res. Commun. 228, 611–615.

    Article  PubMed  CAS  Google Scholar 

  57. Murphy, L. J., Rajkumar, K., and Molnar, P. (1995). Prog. Growth Factor Res. 6, 425–432.

    Article  PubMed  CAS  Google Scholar 

  58. Gutierrez-Ospina, G., Calikoglu, A. S., Ye, P., and D'Ercole, A. J. (1996), Endocrinology 137, 5484–5492.

    Article  PubMed  CAS  Google Scholar 

  59. Lewitt, M. S., Denyer, G. S., Cooney, G. J., et al. (1991). Endocrinology 129, 2254–2256.

    PubMed  CAS  Google Scholar 

  60. Lewitt, M. S., Saunders, H., Cooney, G. J., et al. (1993), J. Endocrinol. 136, 253–260.

    PubMed  CAS  Google Scholar 

  61. Clemmons, D. R. and Gardner, L. I. (1990). J. Cell. Physiol. 145, 129–135.

    Article  PubMed  CAS  Google Scholar 

  62. Elgin, R. G., Busby, W. H., and Clemmons, D. R. (1987). Proc. Natl. Acad. Sci. USA 84, 3254–3258.

    Article  PubMed  CAS  Google Scholar 

  63. Clemmons, D. R., Cascieri, M. A., Camacho-Hubner, C., et al. (1990). J. Biol. Chem. 265, 12,210–12,216.

    CAS  Google Scholar 

  64. Koistinen, R., Itkinen, P., Selenius, P., et al. (1990), Biochem. Biophys. Res. Commun. 173, 408–415.

    Article  PubMed  CAS  Google Scholar 

  65. Galiano, R. D., Zhao, L. L., Clemmons, D. R., Roth, S. I., Lin, X., and Mustoe, T. A. (1996), J. Clin. Invest. 98, 2462–2468.

    PubMed  CAS  Google Scholar 

  66. Bar, R. S., Boes, M., Clemmons, D. R., et al. (1990), Endocrinology 127, 497–499.

    PubMed  CAS  Google Scholar 

  67. Cohen, P., Noveral, J. P., Bhala, A., et al. (1995). Am. J. Physiol. 269, L151-L157.

    PubMed  CAS  Google Scholar 

  68. Bernardini, S., Cianfarani, S., Spagnoli, A., Annicchiarico-Petruzzelli, M., Melino, G., Massoud, R., Boscherini, B., Finazzi-Agro, A., Rosenfeld, R. G., and Federici, G. (1994). J. Neuroendocrinol. 6, 409–413.

    Article  PubMed  CAS  Google Scholar 

  69. Müller, H. L., Oh, Y., Lehrnbecher, T., Blum, W. F., and Rosenfeld, R. G. (1994). J. Clin. Endocrinol. Metab. 79, 428–434.

    Article  PubMed  Google Scholar 

  70. Hardouin, S., Gourmelen, M., Noguiez, P., Seurin, D., Roghani, M., Le Bouc, Y., Povoa, G., Merinee, T. J., Hossenlopp, P., and Binoux, M. (1989), J. Clin. Endocrinol. Metab. 69, 1291–1301.

    PubMed  CAS  Google Scholar 

  71. Kelley, K. M., Oh, Y., Gargosky, S. E., Gucef, Z., Matsumoto, T., Hwa, I., Ng, L., Simpson, D. M., and Rosenfeld, R. G., (1996), Intern. J. Biochem. Cell Biol. 28, 619–637.

    Article  CAS  Google Scholar 

  72. Corkins, M. R., Vanderhoof, J. A., Slentz, D. H., et al. (1995). Biochem. Biophys. Res. Commun. 211, 707–713.

    Article  PubMed  CAS  Google Scholar 

  73. Guo, Y. S., Townsend, C. M., Jr., Jin, G. F., et al. (1995). Am. J. Physiol. 268, E1199-E1204.

    PubMed  CAS  Google Scholar 

  74. Cohen, P., Peehl, D. M., Stamey, T. A., et al. (1993). J. Clin. Endocrinol. Metab. 76, 1031–1035.

    Article  PubMed  CAS  Google Scholar 

  75. Mouhieddine, O. B., Cazals, V., Kuto, E., Le Bone, Y., and Clement, A. (1996), Endocrinology 137, 287–295.

    Article  PubMed  CAS  Google Scholar 

  76. Pintar, J. E., Schuller, A. Wood, T. L., et al. (1996). In: Prog. Growth Factor Res.

  77. Sommer, A., Spratt, S. K., Tatsuno, G. P., et al. (1992). Growth Reg. 3, 46–49.

    Google Scholar 

  78. Gucev, Z. S., Oh, Y., Kelley, K. M., Labarta, J. I., Vorwerk, P., and Rosenfeld, R. G. (1997). Endocrinology 138, 1464–1470.

    Article  PubMed  CAS  Google Scholar 

  79. Vaccarello, M. A., Diamond, F. B., Jr., Guevara-Aguirre, J., Rosenbloom, A. L., Fielder, P. J., Gargosky, S., Cohen, P., Wilson, K., and Rosenfeld, R. G. (1993). J. Clin. Endocrinol. Metab. 77, 273–280.

    Article  PubMed  CAS  Google Scholar 

  80. Kanety, H., Karasik, A., Klinger, B., Silbergeld, A., and Laron, Z. (1993). Acta Endocrinol. 128, 144–149.

    PubMed  CAS  Google Scholar 

  81. Zapf, J., Hauri, C., Waldvogel, M., Futo, E., Hasler, H., Binz, K., Guler, H. P., Schmid, C., and Froesch, E. R. (1989). Proc. Natl. Acad. Sci. USA 86, 3813–3817.

    Article  PubMed  CAS  Google Scholar 

  82. Uchijima, Y., Takenaka, A., Takahashi, S., et al. (1995). Biosci. Biotech. Biochem. 59, 1503–1515.

    Article  CAS  Google Scholar 

  83. Kanzaki, S., Baxter, R. C., Knutsen, R., et al. (1995). J. Bone Min. Res. 10, 854–858.

    Article  CAS  Google Scholar 

  84. Schmid, C., Schlapfer, I., Peter, M., et al. (1994). Am. J. Physiol. 267, E226-E233.

    PubMed  CAS  Google Scholar 

  85. Olney, R. C., Wilson, D. M., Mohtain, M., Fielder, P. J., and Smith, R. L. (1995). J. Endocrinol. 146, 279–286.

    PubMed  CAS  Google Scholar 

  86. Besset, V., Le Magueresse-Battistoni, B., Collette, J., and Benahmed, M. (1996). Endocrinology 137, 296–303.

    Article  PubMed  CAS  Google Scholar 

  87. Oh, Y., Müller, H. L., Ng, L., and Rosenefeld, R. G. (1995). J. Biol. Chem. 270, 13,589–13,592.

    CAS  Google Scholar 

  88. Han, G. R., Dohi, D. F., Lee, H. Y., Rajah, R., Walsh, GL., Hong, W. K., Cohen, P., and Kurie, J. M. (1997). J. Biol. Chem. 272, 13,711–13,716.

    CAS  Google Scholar 

  89. Hayden, J. M., Strong, D. D., Baylink, D. J., Powell, D. R., Sampath, T. K., and Mohan, S. (1997). Endocrinology 138, 4240–4247.

    Article  PubMed  CAS  Google Scholar 

  90. Huynh, H., Yang, Y.F., and Pollak, M. (1996). J. Biol. Chem. 271, 1016–1021.

    Article  PubMed  CAS  Google Scholar 

  91. DiBattista, J. A., Dore, S., Morin, N., Abribat, T. (1996). J. Cell Biochem. 63, 320–333.

    Article  PubMed  CAS  Google Scholar 

  92. Buckbinder, L., Talbott, R., Velasco-Miguel, S., Takenaka, I., Faha, B., Seizinger, B. R., and Kley, N. (1995). Nature 377, 646–649.

    Article  PubMed  CAS  Google Scholar 

  93. Jaques, G., Noll, K., Wegmann, B., Witten, S., Kogan, E., Radulescu, R. T., and Havemann, K. (1997). Endocrinology 138, 1767–1770.

    Article  PubMed  CAS  Google Scholar 

  94. Murphy, L. J., Molnar, P., Lu, X, Huang, H. (1995). J. Mol. Endocrinol. 15, 293–303.

    PubMed  CAS  Google Scholar 

  95. Nickerson, T., Pollak, M., Huynh, H. (1998). Endocrinology 139, 807–810.

    Article  PubMed  CAS  Google Scholar 

  96. Oh, Y., Müller, H. L., Lamson, G., Rosenfeld, R. G. (1993). J. Biol. Chem. 268, 14964–14971.

    PubMed  CAS  Google Scholar 

  97. Conover, C. A., Clarkson, J. T., Durham, S. K., et al. (1994). In. Current Directions in Insulin-Like Growth Factor Research. LeRoith, D. and Raizada, M.K. (eds.). Plenum Press: New York.

    Google Scholar 

  98. DeMellow, J. S. M. and Baxter, R. C. (1988). Biochem. Biophys. Res. Commun. 156, 199–204.

    Article  CAS  Google Scholar 

  99. Conover, C. A. and Powell, D. R. (1991). Endocrinology 129, 710–716.

    PubMed  CAS  Google Scholar 

  100. Hamon, G. A., Hunt, T. K., and Spencer, E. M. (1993). Growth Reg. 3, 55–56.

    Google Scholar 

  101. Clark, R. G., Mortensen, D., Reifsynder, D., et al. (1993). Growth Reg. 3, 50–52.

    CAS  Google Scholar 

  102. Mohan, S., Nakao, Y., Honda, Y., Landale, E., Leser, U., Dony, C., Lang, K., and Baylink, D. J. (1995). J. Biol. Chem. 270, 20,424–20,431.

    CAS  Google Scholar 

  103. Singh, P., Dai, B., Dhruva, B., et al. (1994). Cancer Res. 54, 6563–6570.

    PubMed  CAS  Google Scholar 

  104. Kiefer, M. C., Schmid, C., Waldvogel, M., et al. (1993). Growth Reg. 3, 56–59.

    CAS  Google Scholar 

  105. Booth, B. A., Boes, M., Andress, D. L., et al. (1995). Growth Reg. 5, 1–17.

    CAS  Google Scholar 

  106. Jones, J. I., Gockerman, A., Busby, W. H., Jr., et al. (1993). J. Cell. Biol. 121, 679–687.

    Article  PubMed  CAS  Google Scholar 

  107. Canalis, E. and Gabbitas, B. (1995). J. Biol. Chem. 270, 10,771–10,776.

    CAS  Google Scholar 

  108. Dong, Y. and Canalis, E. (1995). Endocrinology 136, 2000–2006.

    Article  PubMed  CAS  Google Scholar 

  109. Okazaki, R., Riggs, B. L., and Conover, C. A. (1994). Endocrinology 134, 126–132.

    Article  PubMed  CAS  Google Scholar 

  110. Duan, C., Hawes, S. B., Prevette, T., et al. (1996), J. Biol. Chem. 271, 4280–4288.

    Article  PubMed  CAS  Google Scholar 

  111. Ling, N. C., Liu, X. J., Malkowski, M., et al. (1993). Growth Reg. 3, 70–74.

    CAS  Google Scholar 

  112. Imai, Y., Busby, W. H., Jr., Smith, C. E., Clarke, J. B., Garmong, A. J., Horwitz, G. D., Rees, C., and Clemmons, D. R. (1997). J. Clin. Invest. 100, 2596–2605.

    PubMed  CAS  Google Scholar 

  113. Andress, D. L., and Birnbaum, R. S. (1992). J. Biol. Chem. 267, 22,467–22,472.

    CAS  Google Scholar 

  114. Bach, L. A., Thotakura, N. R., and Rechler, M. M. (1993), Growth Reg. 3, 59–62.

    CAS  Google Scholar 

  115. Baxter, R. C. and Saunders, H. (1992). J. Endocrinol. 134, 133–139.

    PubMed  CAS  Google Scholar 

  116. Claussen, M., Buergisser, D., Schuller, A. G., et al. (1995). Mol. Endocrinol. 9, 902–912.

    Article  PubMed  CAS  Google Scholar 

  117. Sheikh, M. S., Shao, Z. M., Hussain, A., et al. (1993). J. Cell. Physiol. 155, 556–67.

    Article  PubMed  CAS  Google Scholar 

  118. Zhou, Y., Mohan, S., Linkhart, T. A., et al. (1996). Endocrinology 137, 975–983.

    Article  PubMed  CAS  Google Scholar 

  119. Powell, D. R., Liu, F., Baker, B. K., Hintz, R. L., Durham, S. K., Brewer, E. D., Frane, J. W., Tonshoff, B., Mehls, O., Wingen, A. M., Watkins, S. L., Hogg, R. J., and Lee, P. D. (1997). J. Clin. Endocrinol. Metab. 82, 2978–2984.

    Article  PubMed  CAS  Google Scholar 

  120. Bach, L. A., Hsieh, S., Brown, A. L., et al. (1994). Endocrinology 135, 2168–2176.

    Article  PubMed  CAS  Google Scholar 

  121. Bach, L. A., Salemi, R., and Leeding, K. S. (1995). Endocrinology 136, 5061–5069.

    Article  PubMed  CAS  Google Scholar 

  122. Binoux, M., Lalou, C., Lassarre, C., et al. (1994). In: Current Directions in Insulin-Like Growth Factor Research. LeRoith, D., and Raizada, M. K. (eds.), Plenum Press, New York.

    Google Scholar 

  123. Cohen, P., Graves, H. C., Peehl, D.M., Kamarei, M., Giudice, L. C., and Rosenfeld, R. G. (1992). J. Clin. Endocrinol. Metab. 75, 1046–1053.

    Article  PubMed  CAS  Google Scholar 

  124. Rajah, R., Bhala, A., Nunn, S. E., Peehl, D. M., and Cohen, P. (1996), Endocrinology 137, 2676–2682.

    Article  PubMed  CAS  Google Scholar 

  125. Conover, C., and DeLeon, D. D. (1994). J. Biol. Chem. 2691, 7076–7080.

    Google Scholar 

  126. Conover, C., Perry, J., and Tindall, D. (1995). J. Clin. Endocrinol. Metab. 80, 987–993.

    Article  PubMed  CAS  Google Scholar 

  127. Nunn, S., Peehl, D. M., and Cohen, P. (1997). J. Cell. Physiol. 171, 196–204.

    Article  PubMed  CAS  Google Scholar 

  128. Claussen, M., Kubler, B., Wendland, M., Neifer, K., Schmidt, B., Zapf, J., and Braulke, T. (1997). Endocrinology 138, 3797–3803.

    Article  PubMed  CAS  Google Scholar 

  129. Fowlkes, J. L., Suzuki, K., Nagase, H., and Thrailkill, K. M. (1994). Endocrinology 135, 2810–2813.

    Article  PubMed  CAS  Google Scholar 

  130. Fowlkes, J. L., Enghild, J. J., Suzuki, K., and Nagase, H. (1994). J. Biol. Chem. 269, 742–746.

    Google Scholar 

  131. Rajah, R., Katz, L., Nunn, S., Solberg, P., Beers, T., and Cohen, P. (1996). Prog. Growth Factor Res. 6, 273–284.

    Article  Google Scholar 

  132. Angelloz-Nicoud, P., Harel, L., and Binoux, M. (1996). Growth Reg. 6, 130–136.

    CAS  Google Scholar 

  133. Zheng, B., Clarke, J. B., Busby, W. H., Duan, C., and Clemmons, D. R. (1998), Endocrinology 139, 1708–1714.

    Article  PubMed  CAS  Google Scholar 

  134. Bereket, A., Wilson, T. A., Kolasa, A. J., Fan, J., and Lang, C. H. (1996). Endocrinology 137, 2238–2245.

    Article  PubMed  CAS  Google Scholar 

  135. Cohen, P., Peehl, D. M., Graves, H. C., and Rosenfeld, R. G. (1994). J. Endocrinol. 142, 407–415.

    PubMed  CAS  Google Scholar 

  136. Claussen, M., Zapf, J., and Braulke, T. (1994). J. Clin. Endocrinol. Metab. 134, 1964–1966.

    CAS  Google Scholar 

  137. Guidice, L. C., Farrel, E. M., Lamson, G., et al. (1990). J. Clin. Endocrinol. Metab. 71, 806–816.

    Google Scholar 

  138. Katz, L. E. L., Stamey, D., Peehl, D. M. et al. (1995). Endocrine Society P-1-204

  139. Blat, C., Villaudy, J., and Binoux, M. (1994). J. Clin. Invest. 93, 2286–2290.

    Article  PubMed  CAS  Google Scholar 

  140. Lassarre, C. and Binoux, M. (1994). Endocrinology 134, 1254–12.

    Article  PubMed  CAS  Google Scholar 

  141. Besnard, N., Pisselet, C., Zapf, J., Hornebeck, W., Monniaux, D., and Monget, P. (1996). Endocrinology 137, 1599–1607.

    Article  PubMed  CAS  Google Scholar 

  142. Tsuboi, R., Shi, C. M., Sato, C., Cox, G. N., Ogawa, H. (1995). J. Invest. Dermatol. 104, 199–203.

    Article  PubMed  CAS  Google Scholar 

  143. Jyung, R. W., Mustoe, J. A., Busby, W. H., and Clemmons, D. R. (1994). Surgery 115, 133–239.

    Google Scholar 

  144. Jacot, T. A. and Clemmons, D. R. (1998). Endocrinology 139, 44–50.

    Article  PubMed  CAS  Google Scholar 

  145. Lawrence, J. B., Oxvig, C., Overgaard, M. T., Sottrup-Jensen, L., Gleich, G. J., Hays, L. G., Yates, J. R., III, and Conover, C. A. (1999). Proc. Natl. Acad. Sci. USA 16: 96, 3149–3153.

    Article  Google Scholar 

  146. Newmann, G. M., Marinaro, J. A., and Bach, L. A. (1998). Biochemistry 37, 6572–6585.

    Article  Google Scholar 

  147. Bereket, A., Lang, C. H., Blethen, S. L., Fan, J., Frost, R. A., and Wilson, T. A. (1995). J. Clin. Endocrinol. Metab. 80, 2282–2288.

    Article  PubMed  CAS  Google Scholar 

  148. Fowlkes, J. L., Thrailkill, K. M., George-Nascimento, C., Rosenberg, C. K., and Serra, D. M. (1997). Endocrinology 138, 2280–2285.

    Article  PubMed  CAS  Google Scholar 

  149. Donnelly, M. J. and Holly, J. M. (1996). J. Endocrinol. 149, R1-R7.

    Article  PubMed  CAS  Google Scholar 

  150. Salahifar, H., Baxter, R. C., and Martin, J. L. (1997). Endocrinology 138, 1683–1690.

    Article  PubMed  CAS  Google Scholar 

  151. Cohen, P., Lamson, G., Okajima, T., et al. (1993). Mol. Endocrinol. 7, 380–386.

    Article  PubMed  CAS  Google Scholar 

  152. Oh, Y., Muller, H. L., Pham, H., et al. (1993). J. Biol. Chem. 268, 26,045–26,048.

    CAS  Google Scholar 

  153. Valentinis, B., Bhala, A., DeAngelis, T., et al. (1995). Mol. Endocrinol. 9, 361–367.

    Article  PubMed  CAS  Google Scholar 

  154. Bicsak, T. A., Shimonaka, M., Malkowski, et al. (1990). Endocrinology 126, 2184–2189.

    Article  PubMed  CAS  Google Scholar 

  155. Villaudy, J., Delbe, J., Blat, C., et al. (1991). J. Cell. Physiol. 149, 492–496.

    Article  PubMed  CAS  Google Scholar 

  156. Lalou, C., Lassarre, C., and Binoux, M. (1996). Endocrinology 137, 3206–3212.

    Article  PubMed  CAS  Google Scholar 

  157. Zadeh, S. M., and Binoux, M. (1997). Endocrinology 138, 3069–3072.

    Article  PubMed  CAS  Google Scholar 

  158. Jones, J. I., Gockerman, A., Busby W. H., et al. (1993). Proc. Natl. Acad. Sci. USA 90, 10,553–10,557.

    CAS  Google Scholar 

  159. Leal, S. M., Liu, Q., Huang, S. S., Huang, J. S. (1997). J. Biol. Chem. 272, 20,572–20,576.

    Article  CAS  Google Scholar 

  160. Noll, K., Wegmann, B., Havemann, K., and Jaques, G. (1996). J. Clin. Endocrinol. Metab. 81, 2653–2662.

    Article  PubMed  CAS  Google Scholar 

  161. Schedlich, L. J., Young, T. F., Firth, S. M., and Baxter, R. C. (1998). J. Biol. Chem. 273, 18,347–18,352.

    Article  CAS  Google Scholar 

  162. Wraight, C. J., Liepe, I. J., White, P. J., Hibbs A. R., Werther G. A. (1998). J. Invest. Dermatol. 111, 239–242.

    Article  PubMed  CAS  Google Scholar 

  163. Jaques, G., Noll, K., Wegmann, B., Witten, S., Kogan, E., Radulescu, R. T., and Havemann, K. (1997). Endocrinology 138, 1767–1770.

    Article  PubMed  CAS  Google Scholar 

  164. Hodgkinson, S., Fowke, P., Al Somai, N., and McQuoid, M. (1995). J. Endocrinol. 145, R1-R6.

    Article  PubMed  CAS  Google Scholar 

  165. Yang, Y. W.-H., Yanagishita, M., and Rechler, M. M. (1996). Endocrinology. 137, 4363–4371.

    Article  PubMed  CAS  Google Scholar 

  166. Ferry, R. J., Katz, L. E., Grimberg, A., Cohen P., Weinzimer S. A. (1999). Horm. Metab. Res. 31, 192–202.

    PubMed  CAS  Google Scholar 

  167. Murphy, L. J. (1998). J. Mol. Endocrinol. 21, 97–107.

    Article  PubMed  CAS  Google Scholar 

  168. Oh, Y., Nagalla, S. R., Yamanaka, Y., Kim, H-S., Wilson, E., and Rosenfeld, R. G. (1996). J. Biol. Chem. 271, 30,322–30,325.

    CAS  Google Scholar 

  169. Murphy, M., Pykett, M. J., Harnish, P., Zang, K. D., and George, D. L. (1993). Cell Growth Differ. 4, 715–722.

    PubMed  CAS  Google Scholar 

  170. Yamauchi, T., Umeda, F., Masakado, M., Isaji, M., Mizushima, S., and Nawata, H. (1994). Biochem. J. 303, 591–598.

    PubMed  CAS  Google Scholar 

  171. Akaogi, K., Okabe, Y., Funahashi, K. Yoshitake, Y., Nishikawa, K., Yasunitsu, H., Umeda, M., and Miyazaki, K. (1994). Biochem. Biophys. Res. Commun. 198, 1046–1053.

    Article  PubMed  CAS  Google Scholar 

  172. Burger, A. M., Zhang, X., Li, H., Ostrowski, J. L., Beatty, B., Venanzoni, M., Papas, T., and Seth, A. (1998). Oncogene 16, 2459–2467.

    Article  PubMed  CAS  Google Scholar 

  173. Kim, H-S., Nagalla, S. R., Oh, Y., Wilson, E., Roberts, C. T., Jr., Rosenfeld, R. G. (1997). Proc. Natl. Acad. Sci. USA 94, 12,981–12,986.

    CAS  Google Scholar 

  174. Bradham, D. M., Igarashi, A., Potter, R. L., Grotendorst, G. R. (1991). J. Cell. Biol. 1114, 1285–1294.

    Article  Google Scholar 

  175. Martinerie, C. Viegas-Pequignot, E., Guenard, I., Dutrillaux, B., Nguyen, V., Bernheim, A., and Perbad, B. (1992). Oncogene 7, 2529–2534.

    PubMed  CAS  Google Scholar 

  176. Jay, P., Berge-Lefranc, J. Marsollier, C., Mejean, C., Taviaux, S., and Berta, P. (1997). Oncogene 14, 1753–1757.

    Article  PubMed  CAS  Google Scholar 

  177. Zumbrum, J. and Trueb, B. (1996). FEBS Lett. 398, 187–192.

    Article  Google Scholar 

  178. Lassalle, P., Molet, S., Janin, A., Heyden, J. V., Tavernier, J., Fiers, W., Devos, R., and Tonnel, A.-B. (1996). J. Biol. Chem. 271, 20,458–20,464.

    CAS  Google Scholar 

  179. Yamanaka, Y., Wilson, E. M., Rosenfeld, R. G., and Oh, Y. (1997). J. Biol. Chem. 272, 30,729–30,734.

    Article  CAS  Google Scholar 

  180. Vorwerk, P., Yamanaka, Y., Spagnoli, A., Oh, Y., and Rosenfeld, R. G. (1998). J. Clin. Endocrinol. 83, 1392–1395.

    Article  CAS  Google Scholar 

  181. Wilson, E. M., Oh, Y., and Rosenfeld, R. G. (1997). J. Clin. Endocrinol. Metab. 82, 1301–1303.

    Article  PubMed  CAS  Google Scholar 

  182. Sprenger, C. C., Damon, S. E., Hwa, V., Rosenfeld, R. G., Plymate, S. R. (1999). Cancer Res. 59, 2370–2375.

    PubMed  CAS  Google Scholar 

  183. Damon, S. E., Haugk, K. L., Swisshelm, K., Quinn, L. S. (1997). Exp. Cell. Res. 237, 192–195.

    Article  PubMed  CAS  Google Scholar 

  184. Yang, D. H., Kim, H-S., Wilson, E. M., Rosenfeld, R. G., and Oh, Y. (1998). J. Clin. Endocrinol. Metab. 83, 2593–2596.

    Article  PubMed  CAS  Google Scholar 

  185. Chevalier, G., Yeger, H., Martinerie, C., Laurent, M., Alami, J., Schofield, P. N., Perbal, B. (1998). Am. J. Pathol. 152, 1563–1575.

    PubMed  CAS  Google Scholar 

  186. Friedlander, P., Haupt, Y., Prives, C., and Oren, M. (1996). Mol. Cell. Biol. 16, 4961–4971.

    PubMed  CAS  Google Scholar 

  187. Ludwig, R. L., Bates, S., and Vousden, K. H. (1996). Mol. Cell. Biol. 16, 4952–4960.

    PubMed  CAS  Google Scholar 

  188. Rajah, R., Valentis, B., and Cohen, P. (1997). J. Biol. Chem. 272, 12,181–12,188.

    Article  CAS  Google Scholar 

  189. Gucev, Z. S., Oh, Y., Kelley, K. M., and Rosenfeld, R. G. (1996). Cancer Res. 56 1545–1550.

    PubMed  CAS  Google Scholar 

  190. Erondu, N. E., Dake, B. L., Moser, D. R., Lin, M., Boes, M., and Bar, R. S. (1996). Growth Reg. 6, 1–9.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Pediatric Endocrinology, Duke University Medical Center, Durham, NC

    Paulo F. Collett-Solberg (Assistant Professor)

  2. Division of Endocrinology, Department of Pediatrics, Mattel Children's Hospital at UCLA, 10833 Le Conte Avenue, MDCC 22-315, 90095-1752, Los Angeles, CA

    Pinchas Cohen (Professor and Director of Research and Training)

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Collett-Solberg, P.F., Cohen, P. Genetics, chemistry, and function of the IGF/IGFBP system. Endocr 12, 121–136 (2000). https://doi.org/10.1385/ENDO:12:2:121

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