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Effects of adrenalectopmy on the stress-induced changes in ovarian sympathetic tone in the rat

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Abstract

A 3-wk period of stress promotes the development of ovarian cysts in rats apparently mediated by increased sympathetic nerve activity and ovarian steroid secretion. After 11 wk of stress, these parameters are indistinguishable from nonstressed control rats. To study adrenal contribution, we adrenalectomized rats and studied the effect of 3-wk of cold/restraint stress (1.5 h/d) on them compared to intact animals. Adrenalectomy (ADX) increased ovarian norepinephrine (NE) release, the content of β-adrenergic receptors (βAR) and basal, but not isoproterenol (Iso)-induced, androgen secretion. Stress to intact animals increased NE release, decreased βAR content, and Iso-induced, but not basal, androgen secretion from the ovary. ADX did not modify the response to stress. We propose a tonic inhibition by the adrenal gland on nerve activity of ovarian nerves. Stress overrides this inhibitory effect, and nerve activity downregulates βAR, decreasing ovarian steroid secretion.

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Authors and Affiliations

  1. Laboratory of Neurobiochemistry, Department of Biochemistry and Molecular Biology, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Casilla 233, Santiago, Chile

    Anita Gálvez, Alfonso Paredes, Jenny L. Fiedler, Mauricio Venegas &  Hernán E. Lara

Authors
  1. Anita Gálvez
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  2. Alfonso Paredes
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  3. Jenny L. Fiedler
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  4. Mauricio Venegas
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  5. Hernán E. Lara
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Correspondence to Hernán E. Lara.

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Gálvez, A., Paredes, A., Fiedler, J.L. et al. Effects of adrenalectopmy on the stress-induced changes in ovarian sympathetic tone in the rat. Endocr 10, 131–135 (1999). https://doi.org/10.1385/ENDO:10:2:131

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  • DOI: https://doi.org/10.1385/ENDO:10:2:131

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