Clinical Reviews in Allergy & Immunology

, Volume 30, Issue 1, pp 19–23

Drug-induced urticarias

  • Pascale Mathelier-Fusade

DOI: 10.1385/CRIAI:30:1:019

Cite this article as:
Mathelier-Fusade, P. Clinic Rev Allerg Immunol (2006) 30: 19. doi:10.1385/CRIAI:30:1:019


Drugs may cause urticaria by different mechanisms. The most well-known mechanism is the allergic reaction mediated by immunoglobulin (Ig)E antibodies, which induce acute generalized urticaria. Allergic reactions to β-lactams are the most common cause of adverse drug reaction mediated by IgE antibodies. However, IgE antibodies are not always necessary to activate the release of mediators from mast cells and induce acute urticarias. Some drugs, such as opiates or codeine, act directly on mast cells, and others, such as aspirin and nonsteroidal anti-inflammatories, induce an exacerbation of chronic urticaria by a pharmacological mechanism involving the arachidonic acid metabolism. Additionally, angioedema is a well-known complication of angiotensin-converting enzyme inhibitors by its action on bradykinin, which is a potent vasodilatator agent. Topical drugs, such as antibiotics, disinfectants, or anesthetics, may cause urticaria, which sometimes progresses to generalized urticaria and, more rarely, to anaphylactoid reactions.

Index Entries

Urticaria angioedema aspirin nonsteroidal anti-inflammatory drugs angiotensin-converting enzyme inhibitors 

Copyright information

© Humana Press Inc 2006

Authors and Affiliations

  • Pascale Mathelier-Fusade
    • 1
  1. 1.Centre d'AllergologieHópital TenonParisFrance

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