Skip to main content

Advertisement

SpringerLink
Log in

Intravenous immunoglobulin in eye involvement

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

Abstract

Ocular inflammation may affect all eye layers: conjunctiva, sclera, uvea, and orbital tissues. The main eye involvement requiring a systemic treatment is uveitis, which represents a heterogeneous group of rare diseases, most of which are sight-threatening. In around 40% of uveitis cases an underlying systemic disease, often of autoimmune origin, can be identified. In autoimmune diseases with intraocular inflammation (IOI), uveitis may be the first clinical manifestation and may represent the most severe sign. Studies in animal models, especially in experimental autoimmune uveitis (EAU), offer the opportunity to investigate the pathogenicity of these disorders. The conventional treatment of IOI includes corticosteroids and immunosuppressive agents, which are efficient in around one-half of the patients; however, their effectiveness is also limited by their iatrogenicity. The effects of intravenous immunoglobulin (IVIg) on ocular inflammation have been investigated in a wide spectrum of autoimmune/systemic diseases. Most publications are case series or open trials. They show favorable results in a subset of indications including mainly ocular cicatricial pemphigoid, Vogt-Koyanagi-Harada syndrome, or birdshot disease. Efficacy results are more debated in other conditions, such as inflammatory demyelinating optic neuritis. In other diseases with IOI (Wegener disease, Behcet’s disease, inflammatory myositis), only case reports are available, suggesting that IVIg may be of some interest.

These observations support the need for controlled trials to demonstrate the efficacy of IVIg and assess their potential steroid-sparing effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nussenblatt, R. B. (2002), Intern Rev Immunol 21, 273–289.

    Article  Google Scholar 

  2. Blakeslee, A. (1986), Sight Saving Review 5, 16.

    Google Scholar 

  3. US Department of Health and Human Services: Vision Research: A National Plan: Report of the Retinal and Choroidal Diseases Panel. 1983–1987, NIH Publication, No. 83-2471, pp. 33.

  4. Smit, R. L., Baarsma, G. S., and De Vries, J. (1993), Int Ophthalmol 17, 71–76.

    Article  PubMed  CAS  Google Scholar 

  5. Bodaghi, B., Cassoux, N., Wechsler, B., et al. (2001), Medicine 80, 263–270.

    Article  PubMed  CAS  Google Scholar 

  6. Wacker, W. B. and Lipton, M. M. (1965), Nature 206, 253–254.

    Article  PubMed  CAS  Google Scholar 

  7. Gery, I., Mochizuki, M., and Nussenblatt, R. B. (1986), Prog. Retinal Res 5, 75.

    Article  Google Scholar 

  8. Whitcup, S. M. and Nussenblatt, R. B. (1993), Ann NY Acad Sci 696, 307–318.

    Article  PubMed  CAS  Google Scholar 

  9. Shinohara, T. et al. (1992), Prog Retinal Res 8, 51.

    Article  Google Scholar 

  10. Chan, C. C., Mochizuki, M., Nussenblatt, R. B., et al. (1985), Cell Immunol Immunopathol 35, 103–110.

    Article  CAS  Google Scholar 

  11. Chan, C. C., Mochizuki, M., Palestine, A. G., et al. (1985), Cell Immunol 96, 430–434.

    Article  PubMed  CAS  Google Scholar 

  12. Saoudi, A., Hurez, V., de Kozak, Y., et al. (1993), Int Immunol 5, 1559–1567.

    Article  PubMed  CAS  Google Scholar 

  13. Hurez, V., Kazatchkine, M. D., Vassilev, T., et al. (1997), Blood 90, 4004–4013.

    PubMed  CAS  Google Scholar 

  14. Obrador, E., Peinado, E., de Kozak, Y., et al. (1999), Ophthalmic Res 31, 59–67.

    Article  PubMed  CAS  Google Scholar 

  15. Nussenblatt, R. B., Palestine, A. G., Chan, C. C., et al. (1991), Am J Ophthalmol 112, 138–146.

    PubMed  CAS  Google Scholar 

  16. Sunakawa, M. (1989), Metab Pediatr Syst Ophthalmol 12, 93–95.

    PubMed  CAS  Google Scholar 

  17. Rosenbaum, J. T., George, R. K., and Gordon, C. (1999), Am J Ophthalmol 127, 545–549.

    Article  PubMed  CAS  Google Scholar 

  18. Ryan, S. J. and Maumenee, A. E. (1980), Am J Ophthalmol 89, 31–45.

    PubMed  CAS  Google Scholar 

  19. LeHoang, P., Ozdemir, N., Benhamou, A., et al. (1992), Am J Ophthalmol 113, 33–35.

    PubMed  CAS  Google Scholar 

  20. Rothova, A., Berendschot, T. T., Probst, K., et al. 92004), Ophthalmology 111, 954–959.

  21. LeHoang, P., Cassoux, N., George, F., et al. (2000), Ocul Immunol Inflamm 8, 49–57.

    Article  PubMed  CAS  Google Scholar 

  22. Karmochkine, M., Kazatchkine, M. D., and Lehoang, P. (1998), Ann Intern Med 129, 1078–1079.

    PubMed  CAS  Google Scholar 

  23. Bartley, G. B., Fatourechi, V., Kadrmas, E. F., et al. (1996), Am J Ophthalmol 121, 284–290.

    PubMed  CAS  Google Scholar 

  24. Perros, P., Crombie, A. L., and Kendall-Taylor, P. (1995), Clin Endocrinol (Oxf) 42, 45–50.

    CAS  Google Scholar 

  25. Prummel, M. F., Mourits, M. P., Blank, L., et al. (1993), Lancet 342, 949–954.

    Article  PubMed  CAS  Google Scholar 

  26. Antonelli, A., Saracino, A., Alberti, B., et al. (1992), Acta Endocrinol (Copenh) 126, 13–23.

    CAS  Google Scholar 

  27. Kahaly, G., Pitz, S., Muller-Forell, W., et al. (1996), Clin Exp Immunol 106, 197–202.

    Article  Google Scholar 

  28. Seppel, T., Schlaghecke, R., Becker, A., et al. (1996), Clin Exp Rheumatol 14, S109-S114.

    PubMed  Google Scholar 

  29. Baschieri, L., Antonelli, A., Nardi, S., et al. (1997), Thyroid 7, 579–585.

    PubMed  CAS  Google Scholar 

  30. Dabelsteen, E., Ullman, S., Thomsen, K., et al. (1974), Acta Derm Venereol 54, 189–192.

    PubMed  CAS  Google Scholar 

  31. Foster, C. S. and Sainz de la Maza, M. (2004), Curr Opin Allergy Clin Immunol 4, 435–439.

    Article  PubMed  Google Scholar 

  32. Chan, R.Y., Bhol, K., Tesavibul, N. et al. (1999), Invest Ophthalmol Vis Sci 40, 2283–2290.

    PubMed  CAS  Google Scholar 

  33. Razzaque, M. S., Foster, C. S., and Ahmed, A. R. (2002), Invest Ophthalmol Vis Sci 43, 2977–2983.

    PubMed  Google Scholar 

  34. Razzaque, M. S., Foster, C. S., and Ahmed, A. R. (2003), Invest Ophthalmol Vis Sci 44, 1616–1621.

    Article  PubMed  Google Scholar 

  35. Razzaque, M. S., Ahmed, B. S., Foster, C. S., et al. (2003), Invest Ophthalmol Vis Sci 43, 3417–3423.

    Article  Google Scholar 

  36. Nakamura, T., Nishida, K., Dota, A., et al. (2002), Invest Ophthalmol Vis Sci 43, 1702–1707.

    PubMed  Google Scholar 

  37. Neuman, R., Taber, J., and Foster, C. S. (1991), Ophthalmology 98, 858–862.

    Google Scholar 

  38. Urcelay, M. L., McQueen, A., and Douglas, W. S. (1997), Br J Dermatol 137, 477–478.

    PubMed  CAS  Google Scholar 

  39. Sami, N., Bhol, K. C., and Razzaque Ahmed, A. (2002), Clin Immunol 102, 59–67.

    Article  PubMed  CAS  Google Scholar 

  40. Sami, N., Letko, E., Androudi, S., et al. (2004), Ophthalmology 111, 1380–1382.

    Article  PubMed  Google Scholar 

  41. Letko, E., Miserocchi, E., Daoud, Y. J., et al. (2004), Clin Immunol 111, 303–310.

    Article  PubMed  CAS  Google Scholar 

  42. Letko, E., Bhol, K., Foster, S. C., et al. (2000), Cur Eye Res 21, 646–654.

    Article  CAS  Google Scholar 

  43. Kumari, S., Bhol, K. C., Rehman, F., et al. (2001), Cytokine 14, 218–224.

    Article  PubMed  CAS  Google Scholar 

  44. Kalina, P. H., Lie, J. T., Campbell, R. J., et al. (1992), Ophthalmology 99, 120–124.

    PubMed  CAS  Google Scholar 

  45. Jayne, D. R., Davies, M. J., Fox, C. J., et al. (1991), Lancet 337, 1137–1139.

    Article  PubMed  CAS  Google Scholar 

  46. Blum, M., Andrassy, K., Adler, D., et al. (1997), Graefe’s Arch Clin Exp Ophthalmol 235, 599–602.

    Article  CAS  Google Scholar 

  47. Helveston, W. R. and Gilmore, R. (1996), Neurology 46, 584–585.

    PubMed  CAS  Google Scholar 

  48. Gonzales-Delgado, M., Gonzalez, C., Blazquez, J. I., et al. (2004), Neurologia 19, 401–403.

    Google Scholar 

  49. Kokotis, P., Theodossiadis, P., Bouros, C., et al. (2005), J Rheumatol 32, 379–381.

    PubMed  Google Scholar 

  50. Shambal, S., Lindner, A., and Zierz, S. (1998), Muscle Nerve 21, 1359–1360.

    Article  PubMed  CAS  Google Scholar 

  51. Beck, R. W., Cleary, P. A., Anderson, M. M. Jr., et al. (1992), N Engl J Med 326, 581–588.

    Article  PubMed  CAS  Google Scholar 

  52. Rodriguez, M. and Lennon, V. A. (1990), Ann Neurol 27, 12–17.

    Article  PubMed  CAS  Google Scholar 

  53. Van Engelen, B. G., Hommes, O. R., Pinckers, A., et al. (1992), Ann Neurology 32(6), 834–835.

    Article  Google Scholar 

  54. Curro Dossi, B., Amadori, A., Cirafisi, C., et al. (1998), Ital J Neurol Sci 19, 45–48.

    Article  PubMed  CAS  Google Scholar 

  55. Frohman, L. P., Cook, S. D., and Bielory, L. (1991), J Clin Neuroophthalmol 11, 241–245.

    PubMed  CAS  Google Scholar 

  56. Noseworthy, J. H., O’Brien, P. C., Petterson, T. M., et al. (2001), Neurology 56, 1514–1522.

    PubMed  CAS  Google Scholar 

  57. Gajdos, P., Chevret, S., Clair, B., et al. (1997), Ann Neurol 41, 789–796.

    Article  PubMed  CAS  Google Scholar 

  58. Guy, J. and Aptsiauri, N. (1999), Arch Ophthalmol 117, 471–477.

    PubMed  CAS  Google Scholar 

  59. Keltner, J. L., Thirkill, C. E., and Yip, P. T. (2001), J Neuroophthalmol 21, 173–187.

    PubMed  CAS  Google Scholar 

  60. Seider, N., Beiran, I., Scharf, J., et al. (2001), Br J Ophthalmol 85, 1287–1288.

    Article  PubMed  CAS  Google Scholar 

  61. Drosos, A. A., Petris, C. A., Petroutsos, G. M., et al. (1989), Clin Rheumatol 8, 49–53.

    Article  PubMed  CAS  Google Scholar 

  62. Aharon, A., Zandman-Goddardd, G., and Shoenfeld, Y. (1994), Clin Rheumatol 13, 631–635.

    Article  PubMed  CAS  Google Scholar 

  63. Callaway, J. K. and Bennett, C. J. (2002), Intern Med J 32, 421–422.

    Article  PubMed  CAS  Google Scholar 

  64. Bachmeyer, C., Turc, Y., Curan, D., et al. (2000), Am J Ophthalmol 129, 101–102.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire Francais du Fractionnement et des Biotechnologies, Les Ulis, France

    Zera Tellier

Authors
  1. Zera Tellier
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tellier, Z. Intravenous immunoglobulin in eye involvement. Clinic Rev Allerg Immunol 29, 295–306 (2005). https://doi.org/10.1385/CRIAI:29:3:295

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/CRIAI:29:3:295

Index Entries

Search

Navigation