Abstract
Indoor air quality is an important issue, because anything we breathe can potentially affect our health. To determine if there is a real health risk, well-designed scientifically valid studies must be performed. Although much attention has focused on sick building syndrome, chemical sensitivities, and mycotoxicosis, there actually is very little evidence that these conditions have an adverse effect on human health. In contrast, real health issues have been shown to exist regarding indoor air triggers of allergies and asthma. Outdoor allergens are difficult to avoid because the pollen grains we encounter outdoors, which are the size that can cause allergies, are windborne and can travel for miles. However, indoor allergens can cause severe allergic symptoms and may also have a priming effect on an individual’s susceptibility to simultaneous or subsequent exposure of other outdoor allergens. Therefore, it is important to minimize exposure to indoor allergens. Determination of individual susceptibility can be paired with knowledge of the patient’s indoor exposure pattern to produce a customized management plan of avoidance, which can be used in conjunction with pharmacological treatment of allergies and asthma, as well as immunotherapy.
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Simons, F. Ancestors of Allergy. New York, New York, Global Medical Communications Publishers, 1994, p. 146.
Cohen, S.G. (2002), J Allergy Clin Immunol 109, 722–724.
Brown, E.A., and Colombo, N.J. (1954), Ann Allergy 12, 14–29.
Ruhl, R.A., Chang, C.C., Halpern, G.M., and Gershwin, M.E. (1993), J Asthma 30, 297–308.
Lyles, W.B., Greve, K.W., Bauer, R.M., et al. (1991), South Med J 84, 65–71, 76.
Finnegan, M.J., Pickering, C.A., and Burge, P.S. (1984), Br Med J (Clin Res Ed) 289, 1573–1575.
Hicks, J.B. (1984), Occup Health Saf 53, 51–56.
(1985) Br Med J (Clin Res Ed) 290, 321–322.
Carey, J., Hager, M., and King, P. (1985), Newsweek 105, 58–60.
Skov, P., and Valkonen, J. (1987), Environ Int 13, 339.
Chang, C.C., Ruhl, R.A., Halpern, G.M., and Gershwin, M.E. (1993), J Asthma 30, 285–295.
Chang, C.C., Ruhl, R.A., Halpern, G.M., and Gershwin, M.E. (1994), J Asthma 31, 127–137.
Nelson, H.S., and Solomon, W.R. (2003), J Allergy Clin Immunol 112, 3–8; quiz 9.
Holmberg, S., and Chen, Q. (2003), Indoor Air 13, 200–204.
Lattimer, G.L., Rhodes, L.V., 3rd, Salventi, J.S., et al. (1979), Ann Intern Med 90, 522–526.
McDade, J.E., Shepard, C.C., Fraser, D.W., Tsai, T.R., Redus, M.A., and Dowdle, W.R. (1977), N Engl J Med 297, 1197–1203.
Glick, T.H., Gregg, M.B., Berman, B., Mallison, G., Rhodes, W.W., Jr., and Kassanoff, I. (1978), Am J Epidemiol 107, 149–160.
Drinka, P.J., Krause, P., Schilling, M., Miller, B.A., Shult, P., and Gravenstein, S. (1996), J Am Geriatr Soc 44, 910–913.
Drinka, P.J., Gravenstein, S., Krause, P., Nest, L., Dissing, M., and Shult, P. (2000), Infect Control Hosp Epidemiol 21, 732–735.
Yu, I.T., Li, Y., Wong, T.W., et al. (2004), N Engl J Med 350, 1731–1739.
Strand, V., Svartengren, M., Rak, S., Barck, C., and Bylin, G. (1998), Eur Respir J 12, 6–12.
Chauhan, A.J., Inskip, H.M., Linaker, C.H., et al. (2003), Lancet 361, 1939–1944.
Togias, A. (2001), Am J Respir Crit Care Med 164, 726,727.
Togias, A. (2004), J Allergy Clin Immunol 113, S8-S14.
Taylor, P.E., Flagan, R.C., Valenta, R., and Glovsky, M.M. (2002), J Allergy Clin Immunol 109, 51–56.
Nordness, M.E., Zacharisen, M.C., and Fink, J.N. (2003), Curr Allergy Asthma Rep 3, 438–446.
Yi, E.S. (2002), Crit Rev Clin Lab Sci 39, 581–629.
Banaszak, E.F., Thiede, W.H., and Fink, J.N. (1970), N Engl J Med 283, 271–276.
Patovirta, R.L., Reiman, M., Husman, T., Haverinen, U., Toivola, M., and Nevalainen, A. (2003), Int J Occup Med Environ Health 16, 221–230.
Buzina, W., Braun, H., Freudenschuss, K., Lackner, A., Habermann, W., and Stammberger, H. (2003), Med Mycol 41, 149–161.
Akerman, M., Valentine-Maher, S., Rao, M., et al. (2003), J. Asthma 40, 55–62.
Platts-Mills, T.A., Vervloet, D., Thomas, W.R., Aalberse, R.C., and Chapman, M.D. (1997), J Allergy Clin Immunol 100, S2-S24.
Platts-Mills, T.A., Tovey, E.R., Mitchell, E.B., Moszoro, H., Nock, P., and Wilkins, S.R. (1982), Lancet 2, 675–678.
Litonjua, A.A., Carey, V.J., Burge, H.A., Weiss, S.T., and Gold, D.R. (2001), J Allergy Clin Immunol 107, 41–47.
Matsui, E.C., Wood, R.A., Rand, C., Kanchanaraksa, S., Swartz, L., and Eggleston, P.A. (2004), J Allergy Clin Immunol 113, 910–915.
Galant, S., Berger, W., Gillman S., et al. (1998), Ann Allergy Asthma Immunol 81, 203–210.
Horner, W.E., Helbling, A., Salvaggio, J.E., and Lehrer, S.B. (1995), Clin Microbiol Rev 8, 161–179.
Surma, M., Adamski, T., Chelkowski, J., et al. (2000), J Appl Genet 41, 237–246.
Assoulin-Daya, Y., Leong, A., Shoenfeld, Y., and Gershwin, M.E. (2002), J Asthma 39, 191–201.
Flappan, S.M., Portnoy, J., Jones, P., and Barnes, C. (1999), Environ Health Perspect 107, 927–930.
Jarvis, B.B., Sorenson, W.G., Hintikka, E.L., et al. (1998), Appl Environ Microbiol 64, 3620–3625.
(2000), MMWR Morb Mortal Wkly Rep 49, 180–184.
Gregory, L., Pestka, J.J., Dearborn, D.G., and Rand, T.G. (2004), Toxicol Pathol 32, 26–34.
Lee, M.G., Li, S., Jarvis, B.B., and Pestka, J.J. (1999), J Toxicol Environ Health A 57, 459–474.
Ueno, Y., and Fukushima, K. (1968), Experientia 24, 1032,1033.
Ueno, Y., Hosoya, M., Morita, Y., Ueno, I., and Tatsuno, T. (1968), J Biochem (Tokyo) 64, 479–485.
Ehrlich, K.C., and Daigle, K.W. (1987), Biochim Biophys Acta 923, 206–213.
Ryu, J.C., Ohtsubo, K., Izumiyama, N., Mori, M., Tanaka, T., and Ueno, Y. (1987), J Toxicol Sci 12, 11–21.
Nagase, M., Alam, M.M., Tsushima, A., Yoshizawa, T., and Sakato, N. (2001), Biosci Biotechnol Biochem 65, 1741–1747.
Mason, C.D., Rand, T.G., Oulton, M., MacDonald, J.M., and Scott, J.E. (1998), Nat Toxins 6, 27–33.
Tsai, Y.J., and Gershwin, M.E. (2002), Compr Ther 28, 140–144.
Toth, J., Schultze-Werninghaus, C., Marks, B., et al. (1998), Allergy 53, 1172–1177.
Gavett, S.H., and Koren, H.S. (2001), Int Arch Allergy Immunol 124, 109–112.
Peat, J.K., Britton, W.J., Salome, C.M., and Woolcock, A.J. (1987), Clin Allergy 17, 291–300.
Woodcock, A., Forster, L., Matthews, E., et al. (2003), N Engl J Med 349, 225–236.
Simpson, A., Simpson, B., Custovic, A., Craven, M., and Woodcock, A. (2003), Clin Exp Allergy 33, 1183–1189.
Custovic, A., Simpson, B.M., Simpson, A., et al. (2000), J Allergy Clin Immunol 105, 252–258.
Simpson, A., and Custovic, A. (2004), Curr Opin Allergy Clin Immunol 4, 45–51.
Arshad, S.H. (2004), Curr Opin Allergy Clin Immunol 4, 119–123.
Almqvist, C., Egmar, A.C., Hedlin, G., et al. (2003), Clin Exp Allergy 33, 1190–1197.
Strachan, D.P. (1989), BMJ 299, 1259,1260.
Riedler, J., Braun-Fahrlander, C., Eder, W., et al. (2001), Lancet 358, 1129–1133.
Kulig, M., Luck, W., Lau, S., et al. (1999), Allergy 54, 220–228.
Gehring, U., Bolte, G., Borte, M., et al. (2001), J Allergy Clin Immunol 108, 847–854.
Williams, L.K., Peterson, E.L., Ownby, D.R., and Johnson, C.C. (2004), J Allergy Clin Immunol 113, 291–296.
Illi, S., von Mutius, E., Lau, S., et al. (2001), BMJ 322, 390–395.
Heinrich, J., Gehring, U., Douwes, J., et al. (2001), Clin Exp Allergy 31, 1839–1845.
Wickens, K., Douwes, J., Siebers, R., et al. (2003), Indoor Air 13, 128–135.
Gereda, J.E., Klinnert, M.D., Price, M.R., Leung, D.Y., and Liu, A.H. (2001), J Allergy Clin Immunol 107, 790–796.
Wright, A.L. (2004), J Allergy Clin Immunol 113, S2-S7.
Prescott, S.L., Taylor, A., King, B., et al. (2003), Clin Exp Allergy 33, 566–572.
Rowe, J., Heaton, T., Kusel, M., et al. (2004), J Allergy Clin Immunol 113, 710–716.
Prescott, S.L., Macaubas, C., Smallacombe, T., Holt, B.J., Sly, P.D., and Holt, P.G. (1999), Lancet 353, 196–200.
Holt, P.G., Clough, J.B., Holt, B.J., et al. (1992), Clin Exp Allergy 22, 1093–1099.
Hesselmar, B., Aberg, N., Aberg, B., Eriksson, B., and Bjorksten, B. (1999), Clin Exp Allergy 29, 611–617.
Custovic, A., Simpson, B.M., Simpson, A., et al. (2003), J Allergy Clin Immunol 111, 402–407.
McIntire, J.J., Umetsu, D.T., and DeKruyff, R.H. Springer Semin Immunopathol 25, 335–348.
de Blay, F., Fourgaut, G., Hedelin, G., et al. (2003), Allergy 58, 27–33.
Campanacci, V., Egloff, M.P., Longhi, S., et al. (2003), Acta Crystallogr D Biol Crystallogr 59, 1628–1631.
Custovic, A., Woodcock, H., Craven, M., et al. (1999), Pediatr Allergy Immunol 10, 258–260.
Platts-Mills, T.A., Heymann, P.W., Longbottom, J.L., and Wilkins, S.R. (1986), J Allergy Clin Immunol 77, 850–857.
Fernandez-Caldas, E., Codina, R., Ledford, D.K., Trudeau, W.L., and Lockey, R.F. (2001), Ann Allergy Asthma Immunol 87, 196–200.
Mora, C., Flores, I., Montealegre, F., and Diaz, A. (2003), Clin Exp Allergy 33, 28–34.
Munir, A.K., Bjorksten, B., Einarsson, R., et al. (1994), Allergy 49, 508–516.
Liccardi, G., Cazzola, M., D’Amato, M., and D’Amato, G. (2000), Respir Med 94, 1109–1118.
Yun, Y.Y., Ko, S.H., Park, J.W., Lee, I.Y., Ree, H.I., and Hong, C.S. (2001), Ann Allergy Asthma Immunol 86, 551–556.
Arbes, S.J., Jr., Sever, M., Archer, J., et al. (2003), J Allergy Clin Immunol 112, 339–345.
de Blay, F., Sanchez, J., Hedelin, G., et al. (1997), J Allergy Clin Immunol 99, 107–112.
van Wijnen, J.H., Verhoeff, A.P., Mulder-Folkerts, D.K., Brachel, H.J., and Schou, C. (1997), Allergy 52, 460–464.
Leung, R., Lam, C.W., Chan, A., et al. (1998), Clin Exp Allergy 28, 585–590.
Hollander, A., Heederik, D., Doekes, G., and Kromhout, H. (1998), Scand J Work Environ Health 24, 228–235.
Chew, G.L., Perzanowski, M.S., Miller, R.L., et al. (2003), Environ Health Perspect 111, 1348–1351.
Phipatanakul, W., Cronin, B., Wood, R.A., et al. (2004), Ann Allergy Asthma Immunol 92, 420–425.
Arruda, L.K., Mann, B.J., and Chapman, M.D. (1992), J Immunol 149, 3354–3359.
Kleine-Tebbe, J., Worm, M., Jeep, S., Matthiesen, F., Lowenstein, H., and Kunkel, G. (1993), Clin Exp Allergy 23, 211–218.
Barnes, C., Tuck, J., Simon, S., Pacheco, F., Hu, F., and Portnoy, J. (2001), Ann Allergy Asthma Immunol 86, 517–523.
Poapolathep, A., Nagata, T., Suzuki, H., Kumagai, S., and Doi, K. (2003), Exp Mol Pathol 75, 74–79.
Berek, L., Petri, I.B., Mesterhazy, A., Teren, J., and Molnar, J. (2001), Toxicol In Vitro 15, 25–30.
Masoli, M., Fabian, D., Holt, S., and Beasley, R. (2004), Allergy 59, 469–478.
Cooper, P.J., Chico, M.E., Rodrigues, L.C., et al. (2003), J Allergy Clin Immunol 111, 995–1000.
Linneberg, A., Ostergaard, C. Tvede, M., et al. (2003), J Allergy Clin Immunol 111, 847–853.
Woodcock, A., Moradi, M., Smillie, F.I., Murray, C.S., Burnie, J.P., and Custovic, A. (2002), Pediatr Allergy Immunol 13, 357–360.
Arshad, S.H., Tariq, S.M., Matthews, S., and Hakim, E. (2001), Pediatrics 108, E33.
Huss, K., Adkinson, N.F., Jr., Eggleston, P.A., Dawson, C., Van Natta, M.L., and Hamilton, R.G. (2001), J Allergy Clin Immunol 107, 48–54.
von Mutius, E. (2002), J Allergy Clin Immunol 109, S525-S532.
Laske, N., Volk, H.D., Liebenthalb, C., et al. (2002), J Allergy Clin Immunol 110, 811–813.
Schauer, U., Hoffjan, S., Bittscheidt, J., et al. (2002), Eur Respir J 20, 1277–1283.
Legg, J.P., Hussain, I.R., Warner, J.A., Johnston, S.L., and Warner, J.O. (2003), Am J Respir Crit Care Med 168, 633–639.
Forster, J., Tacke, U., Krebs, H., et al. (1996), Pediatr Allergy Immunol 7, 55–60.
Fonseca Cde, B., and Grisi, S. (2003), Rev Hosp Clin Fac Med Sao Paulo 58, 39–48.
Bendelja, K., Gagro, A., Bace, A., et al. (2000), Clin Exp Immunol 121, 332–338.
van den Biggelaar, A.H., Lopuhaa, C., van Ree, R., et al. (2001), Int Arch Allergy Immunol 126, 231–238.
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Chang, C., Gershwin, M.E. Indoor air quality and human health. Clinic Rev Allerg Immunol 27, 219–239 (2004). https://doi.org/10.1385/CRIAI:27:3:219
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DOI: https://doi.org/10.1385/CRIAI:27:3:219