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X-linked hyper IgM syndrome

Clinical Reviews in Allergy & Immunology volume 19, pages 205–215 (2000)Cite this article

Summary

X-linked hyper IgM syndrome is largely caused by defects in the CD40L (CD154). The patients have low levels of IgG and have difficulty with respiratory infections as well as opportunistic infections. The morbidity of this syndrome is high; however, early diagnosis and therapy should reduce morbidity and mortality.

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  1. Division of Immunology, Children's Hospital, 300 Longwood Avenue, Fegan Building, 6th Floor, 02115, Boston, MA

    Lynda C. Schneider

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Schneider, L.C. X-linked hyper IgM syndrome. Clinic Rev Allerg Immunol 19, 205–215 (2000). https://doi.org/10.1385/CRIAI:19:2:205

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  • DOI: https://doi.org/10.1385/CRIAI:19:2:205

Keywords

  • Clinical Review
  • Immunology Volume
  • CD40 Ligand
  • CVID Patient
  • Soluble CD40 Ligand