Skip to main content
SpringerLink
Log in

The story of the murine antiendothelial monoclonal antibody BGM

From patients' bedside to laboratory bench and from animal models to patients

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Meroni PL, Del Papa N, Raschi E, Tincani A, Balestrieri G, Youinou P. Antiendothelial cell antibodies (AECA): from a laboratory curiosity to another useful autoantibody. In: Shoenfeld Y (ed.) The Decade of Autoimmunity, New York: Elsevier Science B.V. 1999, p. 285.

    Google Scholar 

  2. Meroni PL, D'Cruz D, Khamastha MA, Youinou P, Hughes GRV. Antiendothelial cell antibodies for scientists or for clinicians too? Clin Exp Immunol 1996; 104: 199–202.

    Article  PubMed  CAS  Google Scholar 

  3. Meroni PL, Del Papa N, Raschi E, Panzeri P, Borghi MO. Is there any pathogenic role for anti-endothelial cell antibodies (AECA) in autoimmune vasculitis? J Biol Reg Homeost Agents 1997; 11: 127–132.

    CAS  Google Scholar 

  4. Le Tonqueze M, Salozhin K, Dueymes M, Piette JC, Kovalev V, Shoenfeld Y, et al. Role of beta 2-glycoprotein I in the antiphospholipid antibody binding to endothelial cells. Lupus 1995; 4: 179–186.

    PubMed  Google Scholar 

  5. Blank M, Tomer Y, Stein M, Kopolovic J, Wiik A, Meroni PL, et al. Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration. Clin Exp Immunol 1995; 102: 120–30.

    Article  PubMed  CAS  Google Scholar 

  6. Shoenfeld Y. Idiotypic induction of autoimmunity: a new aspect of the idiotypic network. FASEB J 1994; 8: 1296–1301.

    PubMed  CAS  Google Scholar 

  7. Bigazzi PE, Rose NR. Animal models of autoimmunity. In: Herzenberg LE, Weir DM, Herzenberg LA, Blackwell C (eds.) Weir's Handbook of Experimental Immunology. Cambridge, MA: Blackwell Science, 1997, pp. 96.1–96.21.

    Google Scholar 

  8. Gross VL, Scmitt WH, Csernok E. ANCA and associated diseases: immunodiagnostic and pathogenetic aspects. Clin Exp Immunol 1990; 79: 47–53.

    Google Scholar 

  9. Damianovich M, Gilburd B, George J, Del Papa N, Afek A, Goldberg I, et al. Pathogenic role of anti-endothelial cell antibodies in vasculitis. Anidiotypic experimental model. J Immunol 1996; 156: 4946–4951.

    PubMed  CAS  Google Scholar 

  10. Bendtzen K, Hansen MB, Svenson M. Immuoinflammatory mediators (cytokines) in trauma. Natural regulation and intervention with systemic complications. In: Borris LC, Lassen MR, Bergquist D (eds.) The Traumatized Patient with Special Reference to Systemic Complications. Aalborg, Denmark: The Venous Thrombosis Group, 1992, pp. 135–144.

    Google Scholar 

  11. Bendtzen K, Hansen MB, Ross C, Svenson M. High-avidity autoantibodies to cytokines. Immunol Today 1998; 19: 209–211.

    Article  PubMed  CAS  Google Scholar 

  12. Levy Y, Gilburd B, George J, Del Papa N, Mallone R, Damianovich M, et al. Characterization of murine monoclonal anti-endothelial cell antibodies (AECA) produced by idiotypic manipulation with human AECA. Intern Immunol 1998; 10: 861–868.

    Article  CAS  Google Scholar 

  13. Del Papa N, Guidali L, Sironi M, Shoenfeld Y, Mantovani A, Tincani A, et al. Anti-endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion. Arthritis Rheum 1996; 39: 758–766.

    Article  PubMed  CAS  Google Scholar 

  14. Carvalho D, Savage COS, Pearson JD. Antiendothelial cell autoantibodies from patients with systemic vasculitis stimulate the release of endothelial cell-derived IL-1. Sarcoidosis 1996; 13: 261 (Abstract).

    Google Scholar 

  15. Del Papa N, Conforti G, Gambini D, La Rosa L, Tincani A, D'Cruz D, et al. Characterization of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis. Clin Immunol Immunopath 1994; 70: 211–216.

    Article  Google Scholar 

  16. Del Papa N, Moroni G, Raschi E, Banfi G, La Rosa L, Catelli L, et al. Antiendothelial cell antibodies (AECA) associate with active renal disease in SLE patients. Lupus 1998; 7: 60 (Abstract).

    Article  Google Scholar 

  17. Del Papa N, Yazici ZA, Raschi E, Goodfrield M, Lindsey NJ, Meroni PL. Human mAb antiendothelial cell antibody (AECA) derived from a SLE patient binds to and activates human umbilical vein endothelial cells (HUVEC). Lupus 1998; 7: 60 (Abstract).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, IRCCS Policlinico, University of Milan, Italy

    Pier Luigi Meroni, Nicoletta Del Papa, Boris Gilburd, Elena Raschi, Paola Panzeri & Maria O. Borghi

  2. Department of Biomedical Sciences, Bradford University, Bradford, UK

    Nigel Lindsey

  3. Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel

    Yehuda Shoenfeld

Authors
  1. Pier Luigi Meroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nicoletta Del Papa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Boris Gilburd
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elena Raschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Paola Panzeri
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria O. Borghi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nigel Lindsey
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yehuda Shoenfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meroni, P.L., Del Papa, N., Gilburd, B. et al. The story of the murine antiendothelial monoclonal antibody BGM. Clinic Rev Allerg Immunol 18, 3–9 (2000). https://doi.org/10.1385/CRIAI:18:1:3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1385/CRIAI:18:1:3

Keywords

Search

Navigation