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Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1

Cell Biochemistry and Biophysics volume 44, pages 43–49 (2006)Cite this article

Abstract

In our study, resveratrol (polyphenol) has been identified as a very important stimulus/agent for the induction of new vessel growth. Occlusion of a main coronary depletes the blood supply to the myocardium and subsequently reduces cardiac function, which ultimately leads to heart failure. Progressive, chronic coronary artery occlusion has been shown to induce development of collateral arteries to re-establish and maintain blood flow to the myocardium at risk via the growth of new capillary vessels or angiogenesis. Studies from our laboratory, as well as from others, have already confirmed the protective role of collaterals against myocardial ischemia and cell death. We have successfully demonstrated in rat myocardial infarction (MI) model an effect of resveratrol on significant upregulation of the protein expression profiles of vascular endothelial growth factor (VEGF) and its tyrosine kinase receptor Flk-1,3 wk after MI. Pretreatment with resveratrol also increased nitric-oxide synthase (inducible NOS and endothelial NOS) along with increased antiapoptotic and proangiogenic factors nuclear factor (NF)-κB and specificity protein (SP)-1. We also were able to demonstrate increased capillary density as well as improved left ventricular function by pharmacological preconditioning with resveratrol 3 wk after MI.

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Authors and Affiliations

  1. Molecular Cardiology Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, CT

    Shoji Fukuda, Shigeaki Kaga, Lijun Zhan, Dipak K. Das & Nilanjana Maulik

  2. Inter Health Research Center, Benicia, CA

    Debasis Bagchi

  3. Department of Pharmacology, Faculty of Medicine, University of Milan, Milan, Italy

    Aldo Bertelli

Authors
  1. Shoji Fukuda
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  2. Shigeaki Kaga
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  3. Lijun Zhan
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  4. Debasis Bagchi
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  5. Dipak K. Das
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  6. Aldo Bertelli
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  7. Nilanjana Maulik
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Correspondence to Nilanjana Maulik.

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Fukuda, S., Kaga, S., Zhan, L. et al. Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Cell Biochem Biophys 44, 43–49 (2006). https://doi.org/10.1385/CBB:44:1:043

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  • DOI: https://doi.org/10.1385/CBB:44:1:043

Index Entries

  • Angiogenesis
  • myocardium
  • resveratrol
  • VEGF
  • Flk-1
  • iNOS
  • eNOS