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Modulation of ion channel function by P2Y receptors

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Abstract

P2Y receptors are classified as P2 purinergic receptors that belong to the superfamily of G-protein coupled receptors. They are distinguishable from P1 (adenosine) receptors in that they bind adenine and/or uracil nucleotide triphosphates or diphosphates depending on the subtype. Over the past decade, P2Y receptors have been cloned from a variety of tissues and species. Eight functional subtypes have been characterized. Nucleotide binding produces activation of specific G-proteins that in turn regulate the function of membrane bound enzymes including phospholipase C and adenylyl cyclase. Certain P2Y receptor subtypes possess a PDZ domain located at the end of the C-terminal region of the receptor. PDZ domains have been established as sites for protein-protein interaction, thus providing a possible mechanism for receptor modulation of membrane protein function independent of G-protein activation. In this review we discuss recent findings that suggest that P2Y receptors can modulate the function of ion channels through multiple protein-protein interactions at the plasma membrane that do not directly involve G-protein activation.

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  1. Department of Physiology and the Molecular Veterinary Biosciences Graduate Program, University of Minnesota, Animal Science/Veterinary Medicine, 55108, St. Paul, MN

    So Yeong Lee & Scott M. O’Grady

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  1. So Yeong Lee
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  2. Scott M. O’Grady
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Correspondence to Scott M. O’Grady.

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Lee, S.Y., O’Grady, S.M. Modulation of ion channel function by P2Y receptors. Cell Biochem Biophys 39, 75–88 (2003). https://doi.org/10.1385/CBB:39:1:75

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