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Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy

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Abstract

Both trace elements and thyroid hormones play essential roles in the human body. However, the previous results about the interaction between these two factors are often controversially given. In order to make clear the influence of thyroid hormones on the homeostasis of trace elements, we studied the variation of Fe, Cu, and Zn in erythrocyte and serum from patients with hyperthyroidism before and after 131I therapy by the X-ray fluorescence method. The different thyroid statuses of the patients before and after the therapy were assayed by determining the levels of thyroid hormones. The results showed that the homeostasis of metal ions in both serum and erythrocyte could be more or less influenced by the altered thyroid hormones. The serum Cu and Zn exhibited the significantly positive correlation with triiodothyronine (T3) and thyroxine (T4). Although the serum Cu and Zn differed significantly before and after the therapy, no difference was observed in the concentrations of Cu and Zn in erythrocyte, except that the erythrocyte Zn in the patients with hypothyroidism exhibited an obvious increase. Furthermore, the erythrocyte Zn showed a markedly negative correlation with T3.

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Authors and Affiliations

  1. Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Academia Sinica, P.O. Box 918, 100039, Beijing, China

    Fang Zhang, Nianqing Liu, Xuefei Wang & Zhifang Chai

  2. Department of Nuclear Medicine, Peking Union Medical College Hospital, 100730, Beijing, China

    Li Zhu

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  1. Fang Zhang
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  2. Nianqing Liu
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  3. Xuefei Wang
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  4. Li Zhu
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Zhang, F., Liu, N., Wang, X. et al. Study of trace elements in blood of thyroid disorder subjects before and after 131I therapy. Biol Trace Elem Res 97, 125–133 (2004). https://doi.org/10.1385/BTER:97:2:125

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  • DOI: https://doi.org/10.1385/BTER:97:2:125

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