Biological Trace Element Research

, Volume 96, Issue 1–3, pp 271–279 | Cite as

Effect of overdose zinc on mouse testis and its relation with sperm count and motility

  • Güfer Turgut
  • Gücin Abban
  • Sabahat Turgut
  • Günur Take


The purpose of this study was to investigate the effects of excessive zinc intake on the testes and on sperm count and motility in mice. Thirty Balb c mice were divided randomly into 3 groups of 10 animals in each. Group I acted as controls; group II was supplied with drinking water containing 1.5 g/100 mL Zn, and group III was supplied with drinking water containing 2.5 g/100 mL Zn. The animals were sacrificed after 3 wk supplementation and the epididymis and testis were quickly excised. A negative correlation between Zn dose and sperm count and motility was found. The sperm count in group III was significantly lower than in groups II and I (p<0.05). The sperm motility in group III was significantly lower than in the controls (p<0.05). Degenerative changes, including spermatic arrest, degeneration of seminiferous tubules, and fibrosis in interstitial tissue, were observed in group III animals. These results show that high doses of zinc significantly alter sperm motility.

Index Entries

Zinc sperm count sperm motility testis mouse histopathology 


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Copyright information

© Humana Press Inc. 2003

Authors and Affiliations

  • Güfer Turgut
    • 1
  • Gücin Abban
    • 2
  • Sabahat Turgut
    • 1
  • Günur Take
    • 3
  1. 1.Department of Physiology, Faculty of MedicinePamukkale UniversityKinikli, DenizliTurkey
  2. 2.Department of Histology and Embryology, Faculty of MedicinePamukkale UniversityKinikli, DenizliTurkey
  3. 3.Department of Histology and Embryology, Faculty of MedicineBaskent UniversityBagcali, AnkaraTurkey

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