Abstract
The study describes the concentrations of zinc, magnesium, copper, iron, and biochemical markers of seminal vesicle and prostate in seminal plasma of different categories of infertile men. The zinc level in oligasthenospermic subjects was significantly higher than in azoospermic, asthenospermic, and oligospermic subjects. The γ-glutamyl transpeptidase activity in both oligoasthenospermic and azoospermic subjects were significantly lower than in asthenospermic and oligospermic individuals. There was no significant difference in iron, copper, and magnesium levels and acid phosphatase activity among the different infertile categories. A positive correlation between zinc and acid phosphatase (r=0.84, r=0.73; p<0.05), and between copper and fructose (r=0.81, r=0.72; p<0.05) was observed in oligoasthenospermic and azoospermic men, respectively. On the basis of our results, it may be postulated that there is a direct effect of the trace elements zinc and copper on acid phosphatase and fructose, respectively, in oligoasthenospermic and azoospermic subjects.
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T.-H. Lin and S.-Y. Cheng, Determination of zinc fractions in human blood and seminal plasma by ultrafiltration and atomic absorption spectrophotometry, Biol. Trace Element Res. 51, 267–276 (1996)
W. Y. Wong, G. Flik, M. W. Pascal, et al., The impact of calcium, magnesium, zinc and copper in blood and seminal plasma on semen parameters in men, Reprod. Toxicol. 15, 131–136 (2001).
M. H. Rayner and K. T. Suzuki, Effect of medium copper concentration on the growth, uptake and intracellular balance of copper and zinc in Menkes’ and normal control cells, Biometals 7, 253–260 (1994).
W. Y. Huang, W. C. Tseng, and S. Y. Cheng, Trace elements and lipid peroxidation in human seminal plasma, Biol. Trace Element Res. 76, 207–215 (2000).
R. R. Paul, J. Chattejee, A. K. Das, et al., Zinc and iron as bioindicators of precancerous nature of oral submucose fibrosis, Biol. Trace Element Res. 54, 213–218 (1996).
C. Anita, G. Chia, and E. H. Morga, Effects of iron deficiency and iron on managanese uptake and deposition in the brain and other organs of the rat, Biol. Trace Element Res. 55, 39–54 (1996).
T. Umeyama, H. Ishikawa, T. Hitoshi, et al., A comparative study of seminal trace elements in fertile and infertile men, Fertil. Steril. 46, 494–499 (1986).
F. R. Abou-Shakra, N. J. Ward, and D. M. Everard, The role of trace elements in male infertility, Fertil. Steril. 52, 307–310 (1989).
R. Stanwell-Smith, S. G. Thompson, A. P. Hainesand, et al., A comparison study of zinc, copper, cadmium, lead levels in fertile and infertile men, Fertil. Steril. 40, 670–677 (1983).
A Carreras and C. Mendoza, Zinc levels in seminal plasma of fertile and infertile men, Andrologia. 22, 279–283 (1990).
G. F. Gonzales and A. Villena, Influence of low corrected seminal fructose levels on sperm chromatin stability in semen from men attending an infertility service, Fertil. Steril. 67, 763–768 (1997).
S. Biswas, K. M. Ferguson, J. Stedronska, et al., Fructose and hormone levels in semen: their correlation with sperm count and motility. Fertil. Steril. 30, 200–204 (1978).
A. Srivastava, S. K. Chopra, and P. R. Dasgupta, Biochemical analyses of human seminal plasma fructose, ascorbate, cholesterol, adenosine triphosphatase, lactic dehydrogenase, Andrologia, 15, 431–435 (1983).
J. H. Aafjes, B. G. Blijenberg, H. J. Wolffensperger, et al., Enzyme activity of human ejaculates, relation with abnormal liquefaction, Andrologia, 17, 87–91 (1985).
I. Figa-Talamanca, M. E. Traina, and E. Urbani, Occupational exposure to metals, solvents and pesticides; recent evidences on male reproductive effects and biological markers, Occup. Med. 51, 174–188 (2001).
T. Abyholm, J. Kofstad, K. Molne, et al., Seminal plasma fructose zinc and magnesium and acid phosphatase in case of male infertility, Int. J. Androl. 4, 75–81 (1981).
E. Vidella, A. M. Blanco, and M. E. Galli, Human seminal biochemistry: fructose, ascorbic acid, citric acid, acid phosphatase and their relationship with sperm count, Andrologia, 31, 212–214 (1981).
J. Papadimas, J. Bourtis, and D. Ikkos, Seminal plasma zinc and magnesium in infertile men, Arch. Androl. 10, 261–268 (1983).
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Pant, N., Srivastava, S.P. Correlation of trace mineral concentrations with fructose, γ-glutamyl transpeptidase, and acid phosphatase in seminal plasma of different categories of infertile men. Biol Trace Elem Res 93, 31–38 (2003). https://doi.org/10.1385/BTER:93:1-3:31
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DOI: https://doi.org/10.1385/BTER:93:1-3:31