Skip to main content

Studies of five microelement contents in human serum, hair, and fingernails correlated with aged hypertension and coronary heart disease

Abstract

Using atomic absorption spectrometry (AAS), five microelements in human serum, hair, and fingernails of aged hypertension, coronary heart disease (diseased group) and aged health control (healthy group) were detected. Results of the t-test are as follows: The iron, zinc, and cadmium contents and Zn/Cu (mol/mol) ratio of the diseased group were significantly higher than that of the healthy group in serum (p<0.01, p<0.05, p<0.01, and p<0.05, respectively); the chromium contents in the serum, hair, and fingernails (p<0.05, p<0.01, and p<0.05, respectively); the iron and zinc contents in the hair and fingernails (p<0.01, p<0.001, p<0.05, and p<0.01 respectively) and Zn/Cu ratio in the hair (p<0.01) of the diseased group were significantly lower than that of the healthy group.

Pathogenic factors of cardiovascular disease have three probabilities: (1) The iron contents of the diseased group were higher than that of the healthy group in serum and lower in hair and fingernails (i.e., abnormal iron metabolism); (2) the zinc contents and the Zn/Cu ratio of the diseased group were higher than that of the healthy group in the serum and the zinc contents in the hair and fingernails and the Zn/Cu ratio in the hair of the diseased group were significantly lower than that of the healthy group; (3) the chromium contents of the diseased group were significantly lower than that of the healthy group in the serum, hair, and fingernails.

This is a preview of subscription content, access via your institution.

References

  1. M. Folin, E. Contiero, and G. M. Vaselli, Trace element determination in human, Biol. Trace Element Res. 31, 159–163 (1991).

    Article  Google Scholar 

  2. J. T. Salonen, K. Nyyssonen, H. Korpela, et al., High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men, Circulation 86, 803–811 (1992).

    PubMed  CAS  Google Scholar 

  3. J. M. McCord, Is iron sufficiency a risk factor in ischemic heart disease? Circulation 83, 1112–1114 (1991).

    PubMed  CAS  Google Scholar 

  4. W-.L Cheng, M-.L Zhao, G-.L Zhang, et al., Determination of serum and erythrocyte iron, serum ferritin, MCH and MCHC related with aged hypertension and coronary heart disease, Spectrosc. Spectral Anal. 19, 383–384 (1999).

    CAS  Google Scholar 

  5. B-P. He, D-Sh. Zhao, L. Zhao, et al., Determination of seven elements in serum of heart disease patients related with blood pressure and biochemical index, Natl. Med. J. China 74, 492–494 (1994).

    CAS  Google Scholar 

  6. Y-Ch. Ci, Microelements and disease, J. China-Japan Friendship Hosp. 11, 360–363 (1997).

    Google Scholar 

  7. H. L. Bank, J. Robson, J. B. Bigelow, et al., Preparation of fingernails for trace element analysis, Clin. Chim. Acta 116, 179–190 (1981).

    PubMed  Article  CAS  Google Scholar 

  8. G. V. Jyengar, W. E. Kallmer, and H. J. M. Bowen, The Elemental Composition of Human Tissues and Body Fluids, Verlag Chemie, New York (1978).

    Google Scholar 

  9. Y. Chen and M. Zhou, Free Radical Medicine, People Surgeon Press, Beijing (1991).

    Google Scholar 

  10. G. S. Thind, Plasma sodium and zinc in human hypertension, Clin. Sci. Mol. Med. 51, 483 (1976).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tang, YR., Zhang, SQ., Xiong, Y. et al. Studies of five microelement contents in human serum, hair, and fingernails correlated with aged hypertension and coronary heart disease. Biol Trace Elem Res 92, 97–103 (2003). https://doi.org/10.1385/BTER:92:2:97

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/BTER:92:2:97

Index Entries

  • AAS
  • serum
  • hair
  • fingernail
  • microelements
  • hypertension
  • coronary heart disease