Abstract
The estimation of the selenium status during pregnancy is of great importance because of the significance of selenium for fetus growth and antioxidant protection of neonates. This problem is especially urgent for Russia and its neighbors because very little data are available and because data on soil selenium predict low intake levels of selenium. A large epidemiological investigation made in various areas of the former USSR allowed us to obtain the first information concerning the subject. Serum samples were obtained during 1990–1998 from 556 female blood donors aged 20–53 yr and 722 pregnant women (18–33 yr) during different times of gestation. The mean serum selenium concentration of nonpregnant women varied from 0.87 µmol/L (Slavutich, Ukraine) to 1.74 µmol/L (Ioshkar-Ola, Mary-El) and that of women at delivery from 0.66 µmol/L (Zaporozie, Ukraine) to 1.34 µmol/L (Sakhalin, Russia). Compilation of literature and present data on serum selenium showed the following relationships: nonpregnant women versus women at delivery, y=x -0.25, r=0.94; women at delivery versus umbilical serum, log y=log x -0.2, r=0.97. The two relationships were used to predict serum selenium values for pregnant women taking into account the progressive serum selenium decrease during advancing pregnancy. In almost half of the towns (i.e. 22–50%), pregnant women were considered to have relative selenium deficiency.
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References
G. Alfthan, Longitudinal study on the selenium status of healthy adults in Finland during 1975–1984, Nutr. Res. 8, 467–476 (1988).
J. Neve, New approaches to assess selenium status and requirement, Nutr. Rev. 58, 363–369 (2000).
R. E. Litov and G. F. Combs, Selenium in pediatric nutrition, Pediatrics 87, 339–351 (1991).
C. Ip, Lessons from basic research in selenium and cancer prevention, J. Nutr. 128, 1845–1854 (1998).
M. P. Rayman, The importance of selenium to human health, Lancet 356, 233–241 (2000).
G. Lockitch, Selenium. Clinical significance and analytical concepts, Crit. Rev. Clin. Lab. Sci. 27, 483–541 (1989).
G. Alfthan, A micromethod for the determination of selenium in tissues and biological fluids by single-test-tube fluorimetry, Anal. Chim. Acta 165, 187–194 (1984).
C. A. Swanson, D. C. Reamer, and C. Veillon, Quantitative and qualitative aspects of selenium utilization in pregnant and nonpregnant women: an application of stable isotope methodology, Am. J. Clin. Nutr. 38, 169–180 (1983).
G. Alfthan, Selenium status on nonpregnant, pregnant women and neonates, Acta Pharmacol. Toxicol. 59, 142–146 (1986).
S. Bro, H. Berendtsen, J. Norgaard, A. Host, and J. Jorgenson, Serum selenium concentration in maternal and umbilical cord blood. Relation to course and outcome of pregnancy. J. Trace Elements Electrolytes Health Dis. 2, 165–169 (1988).
G. Perona, G. C. Guidi, and A. Piga, Neonatal erythrocyte GSHPX deficiency as a sequence of selenium during pregnancy. Br. J. Haematol. 42, 567–574 (1979).
B. A. Zachara, W. Wasowicz, and J. Gromadzinska, Glutathione peroxidase activity, selenium and lipid peroxide concentrations in blood from healthy Polish population. Maternal and cord blood, Biol. Trace Element Res. 10, 175–187 (1986).
D. Behne and W. Wolters, Selenium content and glutathione peroxidase activity in the plasma and erythrocytes of nonpregnant and pregnant women, J. Clin. Chem. Clin. Biochem. 17, 133–135 (1979).
M. Verlinden, M. Van Sprundel, J. C. Van der Anwera, and W. J. Eylenbonsch, The selenium status of Belgian population groups, Biol. Trace Element Res. 5, 103–107 (1983).
G. Alfthan, Effects on selenium fertilization on the human selenium status and the environment, Norw. J. Agric. Sci. 11 (Suppl.), 175–181 (1993).
M. Hyvönen-Dabek, P. Nikkinen-Vikki, and J. T. Dabek, Selenium and other elements in human maternal and umbilical serum as determined simultaneously by protoninduced X-ray emission, Clin. Chem. 30, 529–523 (1984).
C. D. Thomson and M. F. Robinson, Selenium in human health and disease with emphasis on those aspects peculiar to New Zealand, Am. J. Clin. Nutr. 33, 303–323 (1980).
A. Aro, J. Kumpulainen, G. Alfthan, A. V. Voschenko, and N. I. Ivanov. Factors affecting the selenium intake of people in Transbaikalian Russia, Biol. Trace Elem. Res. 40, 277–285 (1994).
M. Kantola, E. Mand, A. Viitak, J. Juravskaja, R. Puskunen, T. Vartiainen, et al., Selenium and cadmium status of mothers during pregnancy and lactation in Finland. Hum. Exp. Toxicol. 16, 620 (1997).
M. Kantola, E. Mand, A. Viitak, J. Juravskaja, R. Puskunen, J. Vartiainen, et al., Selenium contents of serum and human milk from Finland and neighboring countries, J. Trace Elements Exp. Med. 10, 225–232 (1997).
G. Alfthan and J. Neve, Selenium intakes and plasma levels in various populations, in Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, J. T. Kumpulainen and J. T. Salonen, eds., Royal Society of Chemistry, Cambridge, pp. 161–167 (1996).
W. Dobrzynsli, U. Trafikowska, A. Trafikowska, A. Pilecki, W. Szymanski, and B. A. Zachara, Decreased selenium concentration in maternal and cord blood in preterm compared with term delivery. Analyst 123, 93–98 (1998).
P. Anttila, S. Salmela, J. Lehto, and O. Simell, Serum zink, copper and selenium concentrations in healthy mothers during pregnancy, puerperium and lactation: a longitudinal study, in Vitamins and Minerals in Pregnancy and Lactation, H. Berger, ed., Nestle Nutrition Workshop Series 16, Vevey/Raven Press, New York, pp. 265–272 (1988).
A. E. Nicoll, J. Norman, A. Macpherson, and U. Acharya, Association of reduced selenium status in the aetiology of recurrent miscarriage, Br. J. Obsteto. Gynecol. 106, 1188–1190 (1999).
M. Navarro, H. Lopez, V. Perez, and M. C. Lopez, Serum selenium levels during normal pregnancy in healthy Spanish women, Sci. Total Environ. 186, 237–242 (1996)
H. Reyers, M. E. Bayez, M. C. Gonzalez, I. Hernandez, J. Palma, J. Ribalta, et al., Selenium, zink and copper plasma levels in intrahepatric cholestasis of pregnancy, in normal pregnancies and in healthy individuals in Chile, J. Hepatol. 32, 542–549 (2000).
W. L. McKeehan, W. G. Hamilton, and R. G. Ham, Selenium is an essencial trace nutrient for growth of WI-38 diploid human fibroblasts, Proc. Natl. Acad. Sci. USA 73, 2023–2027 (1976).
A. G. Negdanov and S. A. Vlasov, Influence of sodium selenate on steroidohenesis in cows, in Proceedings of Scientific Conference of Trace Elements in Biology and Their Utilization in Agriculture and Medicine, pp. 374–375 (1990) (in Russian).
N. A. Golubkina, J. A. Sokolov, B. A. Emelianov, I. N. Khlopova, S. I. Elkina, V. V. Sergeev, et al., Modulation of infection process by bromocryptin, somatotropin and selenium in mice, the interaction between the severity of infection (viral hepatitis) and levels of selenium, somatotropin, prolactin in patients’ blood, Immunology 6, 27–29 (1997) (in Russian).
N. Golubkina and G. Alfthan, The human selenium status in 27 regions of Russia, J. Trace Elements Med. Biol. 13, 15–20 (1999).
W. Wasowicz, P. Wolkanin, M. Bednarski, J. Gromadzinska, M. Sklodowska, and K. Grzybowska, Plasma trace element (Se, Zn, Cu) concentrations in maternal and umbilical cord blood in Poland. Relation with birth weight, gestation age, and parity, Biol. Trace Element Res. 38, 205–215 (1993).
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Golubkina, N.A., Alfthan, G. Selenium status of pregnant women and newborns in the former soviet union. Biol Trace Elem Res 89, 13–23 (2002). https://doi.org/10.1385/BTER:89:1:13
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DOI: https://doi.org/10.1385/BTER:89:1:13