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Determination of some elements in the cervical mucus of healthy taiwanese women, by GF-AAS

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Abstract

The levels of seven trace elements such as copper, iron, zinc, selenium, cadmium, chromium, and nickel were determined by graphite furnace-atomic absorption spectrometry in the cervical mucus of 45 women residing in Taiwan, Republic of China. These women were in good health and had no precancerous or cancerous lesions on their cervix.

The women were separated into four age groups to establish if there was a relationship between the age of the subjects and the values of these elements in the cervical mucus. By one-way analysis of variance, significant differences in the selenium and nickel concentrations were found among the four age groups (p<0.05). The mean concentration of selenium in each age group was significantly higher for the older women. A significant correlation between age and selenium concentration was found by linear regression (r=0.23, p=0.00048). No significant differences among the concentrations of copper, iron, zinc, cadmium, and chromium were found among these four age groups (p>0.05).

The results presented in this work may be considered as baseline values for these elements in the cervical mucus of healthy Taiwanese women for use as reference in studies on cervical diseases and tissue damage.

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References

  1. L. Blasco, Cervical factor, in Current Therapy of Infertility 1984–1985, 3rd ed., C.-R. Garcia, L. Mastroianni, R. D. Amelar, and L. Dubin, eds., B. C. Decker Inc., Philadelphia, pp. 100–106 (1984).

    Google Scholar 

  2. L. Y. Danial, Selenium metabolism and bioavailability, Biol. Trace Element Res. 54, 185–199 (1996).

    Google Scholar 

  3. P. E. Johnson, D. B. Milne, and G. L. Lykken, Effects of age and sex on copper absrption, biological half-life and status in humans, Am. J. Clin. Nutr. 56, 917–925 (1992).

    PubMed  CAS  Google Scholar 

  4. R. A. Disilvestro and G. P. Carlson, Effects of moderate copper deficiency on carbontetrachloride-induced hepatotoxicity in rats, Proc. Soc. Exp. Biol. Med. 197, 32–35 (1991).

    PubMed  CAS  Google Scholar 

  5. N. W. Solomons, Zinc and copper, in Modern Nutrition in Health and Disease, 8th ed., M. E. Shils and V. R. Young, eds., Lea & Febiger, Philadelphia, pp. 238–262 (1988).

    Google Scholar 

  6. Z. G. Jia, Analysis of serum levels of selenium, zinc, and copper in 132 patients with malignant tumors, Chin. J. Prevent. Med. 25, 205–207 (1991).

    CAS  Google Scholar 

  7. E. L. Ma and Z. M. Jiang, Ion-exchange chromatography in simultaneous determination of serum copper and zinc levels in patients with cancer digestive tract, Chinese Med. J. 106, 118–121 (1993).

    CAS  Google Scholar 

  8. D. J. Malvy, B. Burtschy, J. Arnaud, D. Sommelet, G. Leverger, L. Dostalova, et al., Serum beta-carotene and antioxidant micronutrients, in children with cancer, “Cancer in children and antioxidant micronutrients,” The French Study Group, Inst. J. Epidemiol. 22, 761–771 (1993).

    Article  CAS  Google Scholar 

  9. K. Overvad, D. Y. Wang, J. Olsen, D. S. Allen, E. B. Thorling, and R. D. Bulbrook, Copper/zinc ratio in selected human mammary carcinogenesis: a case-cohort study, Am. J. Epidemiol. 137, 409–414 (1993).

    PubMed  CAS  Google Scholar 

  10. D. Yoshida, Y. Ikeda, and S. Nakazawa, Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors, J. Neurol. Oncol. 16, 109–115 (1993).

    Article  CAS  Google Scholar 

  11. I. Yuel, F. Arpaci, A. Ozet, B. Doner, T. Jarayilanoglu, A. Sayar, et al., Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer, Biol. Trace Element Res. 40, 31–38 (1994).

    Article  Google Scholar 

  12. K. N. Jeejeebhoy, R. C. Chu, E. B. Marliss, G. R. Greenberg, and A. Bruce-Robertson, Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition, Am. J. Clin. Nutr. 30, 531–538 (1977).

    PubMed  CAS  Google Scholar 

  13. M. Vandi, Cadmium content in cigarettes, Lancet 7634, 132 (1969).

    Google Scholar 

  14. A. D. Chiquoine and V. Suntzeff, Sensitivity of mammals to cadmium necrosis in the testis, J. Rep. Fertil. 10, 455–460 (1965).

    Article  CAS  Google Scholar 

  15. S. Saito, I. M. Bush, and W. F. Whitemore, Effects of certain metals and cheiating agents on rat and dog epididymal spermatozoan motility, Fertil. Steril. 18, 517–529 (1967).

    PubMed  CAS  Google Scholar 

  16. G. K. Oster, Reaction of metallic copper with biological substrates, Nature 134, 153–154 (1971).

    Article  Google Scholar 

  17. K. Loewit, Immobilization of human spermatozoa with iron. Basis for a new contraceptive, Contraception 2, 219–224 (1971).

    Article  Google Scholar 

  18. J. Zipper, H. Tatum, L. Pastene, M. Medel, and M. Rivera, Metallic copper as an intrauterine contraceptive adjunt to the “T” device, Am. J. Obestet. Gynec. 105, 1274–1278 (1969).

    CAS  Google Scholar 

  19. K. N. von Kaulla, J. K. Aikawa, P. D. Bruns, and W. T. Wikle, Secretory function of the human uterine cervix, Fertil. Steril. 8, 444–454 (1957).

    Google Scholar 

  20. I. L. Mulay, R. Ray, B. E. Knox, N. H. Suhr, and W. E. Dalaney, Trace-metal analysis of cancerous and noncancerous human tissues, J. Natl. Cancer Inst. 47, 1–13 (1971).

    PubMed  CAS  Google Scholar 

  21. A. E. Schwartz, G. W. Leddicotte, R. W. Fink, and E. W. Friedman, Trace elements in noraml and malignant human breast tissue, Sugery 76, 325–329 (1974).

    CAS  Google Scholar 

  22. P. M. Santoliquido, H. W. Southwick, and J. H. Oliwin, Trace metal levels in cancer of the breast, Surg. Gynecol. Obstet. 142, 65–70 (1976).

    PubMed  CAS  Google Scholar 

  23. S. L. Rizk and H. H. Sky-Pack, Comparison between concentrations of trace elements in normal and neoplastic human breast tissue, Cancer Res. 44, 5390–5394 (1984).

    PubMed  CAS  Google Scholar 

  24. L. N. Vernie, J. J. Goeij, C. Zegers, M. Vries, G. S. Baldew, and J. G. McVie, Cisplatin-induced changes of selenium levels and glutathione peroxidase activities in blood of testis tumor patients, Cancer Lett. 40, 83–91 (1988).

    Article  PubMed  CAS  Google Scholar 

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Chuang, IC., Lee, PN., Lin, TH. et al. Determination of some elements in the cervical mucus of healthy taiwanese women, by GF-AAS. Biol Trace Elem Res 86, 137–143 (2002). https://doi.org/10.1385/BTER:86:2:137

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  • DOI: https://doi.org/10.1385/BTER:86:2:137

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