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Quantitative changes of calcium, phosphorus, and magnesium in common iliac arteries with aging

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Abstract

To elucidate the mechanism of element accumulations in the arteries with aging, the authors investigated the mass ratios among calcium, phosphorus, and magnesium in the common iliac arteries by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of 16 men and 8 women, ranging in age from 65 to 93 yr.

It was found that there were extremely significant correlations between calcium and phosphorus contents, between calcium and magnesium contents, and between phosphorus and magnesium contents in the common iliac arteries. In regard to the mass ratio, although the mass ratio of calcium to phosphorus was almost constant, the mass ratios of magnesium to calcium and phosphorus were different at early and advanced stages of the accumulation of calcium and phosphorus. It was found that both the mass ratios of magnesium to calcium and phosphorus were higher at an early stage of the accumulation of calcium and phosphorus in the arteries than at an advanced stage of the accumulation.

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References

  1. Y. Tohno, S. Tohno, T. Minami, M. Ichii, Y. Okazaki, M. Utsumi, et al., Age-related changes of mineral contents in the thoracic aorta and in the cerebral artery, Biol. Trace Element Res. 54, 23–31 (1996).

    CAS  Google Scholar 

  2. S. Tohno, Y. Tohno, T. Minami, Y. Okazaki, M. Utsumi, F. Nishiwaki, et al., Differential accumulation of calcium and phosphorus in aged human arteries, Acta Anat. Nippon. 72, 451–454 (1997).

    PubMed  CAS  Google Scholar 

  3. S. Tohno, Y. Tohno, T. Minami, Y. Okazaki, M. Utsumi, F. Nishiwaki, et al., High accumulation of elements in the human femoral artery, Biol. Trace Element Res. 57, 27–37 (1997).

    CAS  Google Scholar 

  4. S. Tohno, Y. Tohno, T. Minami, Y. Moriwake, M. Utsumi, F. Nishiwaki, et al., High accumulation of minerals in the human arteries of lower limb, Biol. Trace Element Res. 63, 177–183 (1998).

    CAS  Google Scholar 

  5. Y. Tohno, S. Tohno, T. Minami, M. Utsumi, Y. Moriwake, F. Nishiwaki, et al., Age-related changes of mineral contents in the human aorta and internal thoracic artery, Biol. Trace Element Res. 61, 219–226 (1998).

    CAS  Google Scholar 

  6. S. Tohno and Y. Tohno, Age-related differences in calcium accumulation in human arteries, Cell. Mol. Biol. 44, 1253–1263 (1998).

    PubMed  CAS  Google Scholar 

  7. S. Tohno, M. Masuda, Y. Tohno, Y. Moriwake, T. Minami, M. Utsumi, et al., High accumulation of calcium and phosphorus in human iliac arteries, Biol. Trace Element Res. 70, 41–49 (1999).

    CAS  Google Scholar 

  8. M. Masuda, S. Tohno, Y. Tohno, T. Minami, Y. Moriwake, M. Yamasaki, et al., Element content of human umbilical artery and vein in umbilical cord, Biol. Trace Element Res. 69, 235–240 (1999).

    CAS  Google Scholar 

  9. Y. Tohno, S. Tohno, Y. Tateyama, Y. Kida, T. Yasui, M. Hashimoto, et al., Visual demonstration of calcium accumulation in human arteries of upper and lower limbs, Biol. Trace Element Res., 81, 115–125 (2001).

    Article  CAS  Google Scholar 

  10. S. Tohno, Y. Tohno, T. Minami, Y. Moriwake, F. Nishiwaki, M. Utsumi, et al., Calcium and phosphorus in aged human cerebral arteries, Biol. Trace Element Res., 81, 105–113 (2001).

    Article  CAS  Google Scholar 

  11. S. Tohno, Y. Tohno, M. Hayashi, Y. Moriwake, T. Minami, F. Nishiwaki, et al., Accumulation of calcium in the arteries of Japanese monkey, Biol. Trace Element Res., in press.

  12. Y. Tohno, S. Tohno, Y. Moriwake, C. Azuma, Y. Ohnishi, and T. Minami, Accumulation of calcium and phosphorus accompained by increase of magnesium and decrease of sulfur in human arteries, Biol. Trace Element Res., in press.

  13. Y. Tohno, S. Tohno, Y. Moriwake, C. Azuma, Y. Ohnishi, and T. Minami, Simultaneous accumulation of calcium, phosphorus, and magnesium in human various arteries, Biol. Trace Element Res., in press.

  14. Y. Moriwake, Y. Tohno, S. Tohno, C. Azuma, and T. Minami, Relationships among element contents in the intimal, middle, and external tunicae of the thoracic aorta, Biol. Trace Element Res., in press.

  15. S. Tohno, Y. Tohno, M. Hayashi, Y. Moriwake, and T. Minami, Accumulation of magnesium as well as calcium and phosphorus in Japanese monkey arteries with aging, Biol. Trace Element Res., in press.

  16. Y. Tohno, S. Tohno, H. Matsumoto, and K. Naito, A trial of introducing soft X-ray apparatus into dissection practice for students, J. Nara Med. Assoc. 36, 365–370 (1985) (in Japanese).

    Google Scholar 

  17. S. Y. Yu and H. T. Blumenthal, The calcification of elastic fibers. I. Biochemical studies, J. Gerontol. 18, 119–126 (1963).

    PubMed  CAS  Google Scholar 

  18. B. T. Altura, M. Brust, S. Bloom, R. L. Barbour, J. G. Stempak, and B. M. Altura, Magnesium dietary intake modulates blood lipid levels and atherogenesis, Proc. Natl. Acad. Sci. USA 87, 1840–1844 (1990).

    Article  PubMed  CAS  Google Scholar 

  19. B. M. Altura and B. T. Altura, New perspectives on the role of magnesium in the pathophysiology of the cardiovascular system. I. Clinical aspects, Magnesium 4, 226–244 (1985).

    PubMed  CAS  Google Scholar 

  20. M. Hayashi, T. Osakabe, F. Ushio, and Y. Seyama, Qualitative change in the elastin from the calcified portion of human artery, Jpn. J. Geriat. 36, 404–407 (1999) (in Japanese).

    CAS  Google Scholar 

  21. Y. Tohno, S. Tohno, T. Minami, Y. Moriwake, M. Utsumi, F. Nishiwaki, et al., A possible balance of calcium accumulations among bone, cartilage, artery, and vein in single human individuals, Biol. Trace Element Res. 63, 105–111 (1998).

    CAS  Google Scholar 

  22. Y. Tohno, S. Tohno, T. Minami, Y. Moriwake, M. Utsumi, and M.-o. Yamada, A possible balance of phosphorus accumulations among bone, cartilage, artery, and vein in single human individuals, Biol. Trace Element Res. 69, 241–248 (1999).

    CAS  Google Scholar 

  23. S. Tohno, Y. Tohno, M. Masuda, T. Minami, Y. Moriwake, M. Utsumi, et al., A possible balance of magnesium accumulations among bone, cartilage, artery, and vein in single human individuals, Biol. Trace Element Res. 70, 233–241 (1999).

    CAS  Google Scholar 

  24. A. Bigi, E. Foresti, A. Incerti, A. Ripamonti, and N. Roveri, Structural and chemical characterization of the inorganic deposits in calcified human aortic wall, Inorgan. Chim. Acta 55, 81–85 (1980).

    Article  Google Scholar 

  25. R. Z. Le Geros, S. R. Contiguglia, and A. C. Alfrey, Pathological calcification associated with uremia, two types of calcium phosphate deposits, Calcif. Tissue Res. 13, 173–185 (1973).

    Article  Google Scholar 

  26. N. C. Blumenthal, F. Betts, and A. S. Posner, Stabilization of amorphous calcium phosphate by Mg and ATP, Calcif. Tissue Res. 23, 245–250 (1977).

    Article  PubMed  CAS  Google Scholar 

  27. Y. Tohno, S. Tohno, M. Utsumi, T. Minami, M. Ichii, Y. Okazaki, et al., Age-independent constancy of mineral contents in human vertebrae and auditory ossicles, Biol. Trace Element Res. 59, 167–175 (1997).

    CAS  Google Scholar 

  28. Y. Tohno, M. Utsumi, S. Tohno, T. Minami, Y. Moriwake, M.-o. Yamada, et al., A constancy of mineral contents in human auditory ossicles, Acta Anat. Nippon. 72, 531–534 (1997).

    PubMed  CAS  Google Scholar 

  29. M. D. Grynpas, K. P. H. Pritzker, and R. G. V. Hancock, Neutron activation analysis of bulk and selected trace elements in bones using a low flux slowpoke reactor, Biol. Trace Element Res. 13, 333–344 (1987).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, 634-8521, Nara, Japan

    Setsuko Tohno, Yoshiyuki Tohno, Yumi Moriwake, Cho Azuma & Yoshiaki Ohnishi

  2. Kinki University Toyo-oka Junior College, Toyo-oka, 668-8580, Hyogo, Japan

    Takeshi Minami

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  1. Setsuko Tohno
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  2. Yoshiyuki Tohno
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  3. Yumi Moriwake
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  4. Cho Azuma
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  5. Yoshiaki Ohnishi
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  6. Takeshi Minami
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Tohno, S., Tohno, Y., Moriwake, Y. et al. Quantitative changes of calcium, phosphorus, and magnesium in common iliac arteries with aging. Biol Trace Elem Res 84, 57–66 (2001). https://doi.org/10.1385/BTER:84:1-3:057

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  • DOI: https://doi.org/10.1385/BTER:84:1-3:057

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