Abstract
A multitracer solution obtained from the nuclear reaction of selenium with 25-MeV/nucleon 40Ar ions was orally administered to normal and tumor-bearing Balb/c male mice. After 96 h, the mice were sacrificed and the elemental distribution was determined in various tissues, organs, and blood. The uptake of Na, Rb, Ga, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Tc, Ru, Ag, and In in normal and, except for zinc, in tumor-bearing mice was simultaneously detected. Most elements were distributed in about the same manner in the skin and liver of animals in both groups. The distribution of Rb, Ga, V, Cr, Tc, and In showed little or no significant differences between the two study groups. The distribution of Na, Mn, Fe, Ag, Sc, and Co showed significant differences between normal and tumor-bearing mice. In the blood, spleen, and kidney of the normal mice, there was good absorption of Na, Mn, Fe, Ag, Co, and Zn. In the heart, these elements were well absorbed, except for Na and Mn.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
S. Ambe, S. Y. Chen, Y. Ohkubo, Y. Kobayashi, H. Maeda, M. Iwamoto, et al., Multitracer a new tracer technique: its principles, features, and applications, J. Radioanal. Nucl. Chem. Articles 195, 297–304 (1995).
S. Ambe, Y. Ohkubo, Y. Kobayashi, M. Iwamoto, H. Maeda, and M. Yanokura, Multitracer study on transport and distribution of metal ions in plants, J. Radioanal. Nucl. Chem. Articles 195, 305–311 (1995).
S. Y. Chen, S. Ambe, and F. Ambe, Preparation of a radioactive multitracer solution from iron foil irradiated by 0–80 MeV/nucleon 16O ions, J. Radioanal. Nucl. Chem. Lett. 186, 113–114 (1994).
R. Hirunuma, K. Endo, M. Yanaga, S. Enomoto, S. Ambe, A. Tanaka, et al., The use of a multitracer technique for the studies of the uptake and retention of trace element in rats, Appl. Radiat. Isot. 48, 727–733 (1997).
X. Wang, J. Tian, X. M. Yin, X. Zhang, and Q. Z. Wang, The excretion of biotrace element using the multitracer technique in tumor-bearing mice, Appl. Radiat. Isot. 53, 969–974 (2000).
X. M. Yin, X. Wang, X. Zhang, W. X. Li, Z. Tao, and J. Zh. Du, Preparation of a radioactive multitracer solution from the reaction of selenium with 25 MeV nucleon 40Ar ions, J. Radioanal. Nucl. Chem. 221, 225–226 (1997).
W. X. Li, X. M. Yin, Q. Zh. Lou, L. L. Zhao, T. Y. Sun, and D. Q. Wu, Mass yield distribution of target residues from the reaction of indium with 42 MeV/nucleon 12C ion, Phys. Rev. C 46, 1538–1541 (1992).
U. Reus and W. Westmeier, Catalog of gamma rays from radioactive decay, Atomic Data Nucl. Data Tables 29, 193 (1983).
X. Wang, X. M. Yin, X. Zhang, Z. W. Li, J. Tian, M. Wu, et al., Excretion of biotrace elements using the multitracer technique in mice, J. Radioanal. Nucl. Chem. 240, 963–967 (1999).
M. E. Percy, S. Wong, S. Bauer, N. Liaghati-Nasseri, M. D. Perry, V. M. Chauthaiwale, et al., Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insights. Analyst 123, 41–50 (1998).
J. J. Li, N. H. Colburn, and L. W. Oberley, Maspin gene expression in tumor suppression induced by overexpressing manganese-containing superoxide dismutase cDNA in human breast cancer cells, Carcinogenesis 19, 833–839 (1998).
R. Paramanantham, K-H. Sit, and B-H. Bay, Adding Zn2+ Induces DNA fragmentation in and cell condensation in cultured humar chang liver cells, Biol. Trace Element Res. 58, 135–147 (1997).
A. Benardeau, S. N. Hatem, and C. R. Martin, Contribution of Na+/Ca2+ exchange to action potential of human atrial myocytes, Am. J. Physiol. 271, H1151-H1161 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wang, X., Tian, J., Yin, X.M. et al. Distribution of trace elements in normal and tumor-bearing mice using the multitracer technique. Biol Trace Elem Res 81, 177–183 (2001). https://doi.org/10.1385/BTER:81:2:177
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/BTER:81:2:177