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Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products

Biological Trace Element Research volume 77, pages 273–285 (2000)Cite this article

Abstract

Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products was tested. Wheat obtained by application of an original combination and procedure for foliar supplementation of plants with Se was characterized on the average by five times higher content of Se, the main form being l-(+)-selenomethionine (SeMet). Substitution of Se-deficient wheat by wheat naturally enriched with Se and its products contributed to the increase of daily intake on the average by 18 µg (12–35 µg) in volunteers, which is more than 50% of the average daily intake.

Six weeks after the beginning of its application, increased daily intake of Se brought about the increase of its concentration in the plasma of the examined persons by 53%, in their erythrocytes by 37%, in their hair by 44%, and in their urine by 54%. This result was comparable to the effect obtained in the course of an 8-wk daily intake of supplements with 100 µg Se in the form of enriched bakery yeast.

Analysis of glutathione peroxidase (GSH-Px) activity in blood, thiobarbituric acid reactive substances (TBARS) in plasma, lipid parameters (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides), and glucose in serum of volunteers showed that the increased Se intake induced increased GSH-Px activity in blood and decreased concentrations of TBARS, lipid parameters, and glucose in blood.

Using only one crop (wheat enriched with Se), the existing deficiency of Se in our population can be alleviated. In this way, one-fourth of our population with lower Se intake than 21 µg/d will satisfy basal requirements, whereas one-half will become moderately deficient in Se instead of distinctly deficient in Se.

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References

  1. J. E. Oldfield, Feedstuffs. 5, 11 (1990).

    Google Scholar 

  2. J. A. Tan and Y. Huang, Water Air Soil Pollut. 57–58, 59 (1991).

    Article  Google Scholar 

  3. CAS: The group of Environmental and Endemic Diseases—Institute of Geography, J. Chin. Georgr. 1, 71 (1990).

    Google Scholar 

  4. V. R. Young, A. Nahapetanin, and M. Janghorbani, Am. J. Clin. Nutr. 35, 27 (1982).

    Google Scholar 

  5. L. Johnsson, B. Åkesson, and J. Alexander, Swedish Environmental Protection Agency, Stockholm, p. 51 (1997).

  6. I. H. Waschulewski and T. D. Sunde, J. Nutr. 118, 367 (1988).

    PubMed  CAS  Google Scholar 

  7. N. Esaki, T. Nakamura, H. Tanaka, and K. Soda, J. Biol. Chem. 257, 4386 (1982).

    PubMed  CAS  Google Scholar 

  8. H. E. Ganther, Biochemistry 7, 2898 (1968).

    PubMed  Article  CAS  Google Scholar 

  9. H. E. Ganther, Biochemistry 10, 4089 (1984).

    Article  Google Scholar 

  10. M. Bjornstedt, S. Kumar, and A. Holmgreen, Methods Enzymol. 252, 209 (1995).

    PubMed  CAS  Article  Google Scholar 

  11. S. C. Low, J. W. Harney, and M. J. Berry, J. Biol. Chem. 270, 21,659 (1995).

    CAS  Google Scholar 

  12. M. Janghorbani, R. F. Martin, L. J. Kasper, X. F. Sun, and V. R. Youg, Am. J. Clin. Nutr. 51, 670 (1990).

    PubMed  CAS  Google Scholar 

  13. FAO/IAEA/WHO (Food and Agricultural Organization/International Atomic Energy Agency/World Health Organization), Trace Elements in Human Nutrition and Health, World Health Organization, Geneva (1996).

    Google Scholar 

  14. L. Djujic, M. Milovac, and V. Djermanovic, Proceedings Sixth International Symposium on the Uses of Selenium and Tellurium, I. Palmiery, ed., STDA, Brussels, p. 129 (1998).

    Google Scholar 

  15. I. Djujic, in Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, The Royal Society of Chemistry (Cambridge), p. 199 (1996).

    Google Scholar 

  16. J. A. Butler, C. D. Thomson, P. D. Wrangler, and M. F. Robinson, Am. J. Clin. Nutr. 53, 748 (1991).

    PubMed  CAS  Google Scholar 

  17. Y. Xia, X. Zhao, L. Zhu, and P. D. Whanger, J. Nutr. Biochem. 3, 202 (1992).

    Article  CAS  Google Scholar 

  18. Y. Xia, X. Zhao, L. Zhu, and P. D. Whanger, J. Nutr. Biochem. 3, 211 (1992).

    Article  CAS  Google Scholar 

  19. Y. Seko, Y. Saito, J. Kitahara, and N. Imura, in Selenium in Biology and Medicine, A. Wendel, ed., Springer-Verlag, Berlin, p. 70 (1989).

    Google Scholar 

  20. J. E. Spallholz, W. Ted, L. Reid, M. Boylan, and B. J. Shriver, Proceedings Sixth Internatyonal Symposium on the Uses Selenium and Tellurium, Y. Palmiery, ed., STDA, Brussels, p. 47 (1998).

    Google Scholar 

  21. I. Djujic, and M. Milovac, Combination used for the foliar supplementation of plants with Se salts and urea, Patent No. WO 99/29639, PCT/YU 98/00022 (1998).

  22. I. Djujic, and M. Milovac, Combination used for the foliar supplementation of plants with Se salts and urea, Patent No. WO 99/29624, PCT/YU 98/00023 (1998).

  23. D. E. Paglia and W. N. Valentine, J. Lab. Clin. Med. 70, 158 (1967).

    PubMed  CAS  Google Scholar 

  24. K. Satoh, Clin. Chim. Acta 90, 37 (1978).

    PubMed  Article  CAS  Google Scholar 

  25. M. Uchiyama and M. Michara, Ann. Biochem. 86, 271 (1978).

    Article  CAS  Google Scholar 

  26. D. Drabkin and H. Austin, J. Biol. Chem. 112, 51 (1935).

    CAS  Google Scholar 

  27. G. L. Xu, S. C. Wang, B. Q. Gu, Y. X. Yang, H. B. Song, W. L. Xue, et al., Biomed. Environ. Sci. 10, 316 (1997).

    PubMed  CAS  Google Scholar 

  28. P. Ekholm, M. Ylinen, M. Eurola, P. Koivistoinen, and P. Varo, Milchwissenschaft 46, 547 (1991).

    Google Scholar 

  29. P. Varo, Norw. J. Agric. Sci. 11(Suppl.), 151 (1993).

    Google Scholar 

  30. J. Djujic, J. Vucetic, V. Matic, V. Milic, and M. Vrvic, Trace Elements in Health and Disease, G. T. Yurger, O. Donna, and L. Kayrin, eds., Curukova University, Adana, Turkey, p. 579 (1991).

    Google Scholar 

  31. H. M. Meltzer, K. Bibow, I. T. Paulsen, H. H. Mundal, G. Norheim, and H. Holm, Biol. Trace Element Res. 36, 229 (1993).

    CAS  Google Scholar 

  32. Y. Xia, K. E. Hill, and R. F. Burk, J. Nutr. 119, 1318 (1989).

    PubMed  CAS  Google Scholar 

  33. P. D. Whanger, J. Trace Elements Exp. Med. 11, 227 (1998).

    Article  CAS  Google Scholar 

  34. J. T. Salonen, R. Salonen, K. Seppānen, M. Kantola, M. Parvianen, G. Alfthan, et al., Atherosclerosis 70, 155 (1988).

    PubMed  Article  CAS  Google Scholar 

  35. P. Suadicani, H. O. Hein, and F. Gyntelberg, Atherosclerosis 96, 33 (1992).

    PubMed  Article  CAS  Google Scholar 

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Affiliations

  1. Department of Chemistry, Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11000, Belgrade, Yugoslavia

    Ivana S. Djujić & Verica Djermanović

  2. Institute of Nuclear Sciences “Vinča”, 11000, Belgrade, Yugoslavia

    Olga N. Jozanov-Stankov

  3. Institute of Agriculture, Petra Drapšina 15, 23000, Zrenjanin, Yugoslavia

    Milica Milovac

  4. Faculty of Medicine, Department of Physiology, Višegradska 26, 11000, Belgrade, Yugoslavia

    Violeta Janković

Authors
  1. Ivana S. Djujić
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  2. Olga N. Jozanov-Stankov
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  3. Milica Milovac
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  4. Violeta Janković
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  5. Verica Djermanović
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Djujić, I.S., Jozanov-Stankov, O.N., Milovac, M. et al. Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products. Biol Trace Elem Res 77, 273–285 (2000). https://doi.org/10.1385/BTER:77:3:273

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  • DOI: https://doi.org/10.1385/BTER:77:3:273

Index Entries

  • Selenium
  • wheat
  • wheat products
  • enrichment
  • intake
  • bioavailability
  • humans