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Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat

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Abstract

The effect of sodium selenite (0.05, 0.1, and 0.2 mg/kg body weight, ip) on the lipid levels (total lipids, phospholipids, cholesterol, gangliosides), thiobarbituric acid reactive substance (TBARS), and sulfhydryl group (-SH) in the straitum and thalamus of a male Wistar rat was studied after 7 d of treatment. The level of total lipids and cholesterol was significantly and dose-dependently elevated in the straitum and thalamus with 0.1 and 0.2 mg/kg of sodium selenite. However, the cholesterol level was significantly increased only with 0.2 mg/kg of sodium selenite in the thalamus. The level of phospholipids and gangliosides was more significant with 0.1 mg/kg of sodium selenite as compared to 0.2 mg. No significant alteration on the gangliosides level was observed in the thalamus with various doses of sodium selenite although the elevation with 0.2 mg dose was 25.9%. The content of TBARS was elevated dose dependently in straitum, but its level was depleted significantly with 0.1-mg/kg dose of sodium selenite in the thalamus. The level of the -SH group was significantly depleted in the straitum with 0.1-mg/kg dose of sodium selenite; conversely, this dose has significantly elevated the levels of-SH group in the thalamus.

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Authors and Affiliations

  1. Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard, 110062, New Delhi, India

    Suhaila Zia & Fakhrul Islam

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  1. Suhaila Zia
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  2. Fakhrul Islam
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Zia, S., Islam, F. Selenium altered the levels of lipids, lipid peroxidation, and sulfhydryl groups in straitum and thalamus of rat. Biol Trace Elem Res 77, 251–259 (2000). https://doi.org/10.1385/BTER:77:3:251

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  • DOI: https://doi.org/10.1385/BTER:77:3:251

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