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Biological Trace Element Research

, Volume 77, Issue 3, pp 193–197 | Cite as

Selenium, boron, and germanium deficiency in the etiology of Kashin-Beck disease

  • Xu Peng
  • Zeng Lingxia
  • G. N. Schrauzer
  • Guo Xiong
Article

Abstract

Concentrations of selenium (Se), boron (B), and germanium (Ge) were determined in scalp hair of children with Kashin-Beck disease (KBD), in healthy children in KBD-disease endemic areas, and in healthy children in non-KBD areas. Mean Se, B, and Ge concentrations were low in children with KBD; in hair of healthy children in KBD areas, Se levels were normal but B and Ge levels were lower than in KBD-free areas. The hair levels of B and Ge were unaffected by selenium supplementation. It is suggested that B and Ge deficiency may be contributing factors in the etiology of KBD.

Index Entries

Kashin-Beck disease scalp hair boron germanium selenium 

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References

  1. 1.
    Guo Xiong, Zhang Shiyuan, and Mo Dongxu, A role of low selenium on the occurrence of Kashin-Beck disease. Chinese Journal of Controlling Endemic Diseases 8(2), 82–84 (1999).Google Scholar
  2. 2.
    Guo Xiong, Aigner Thomas, Lammi Pirkko, et al., A study of abnormal chondrocyte differentiation and abnormal expression of collagen types in articular cartilage from patients with Kaschin-Beck disease. Chinese Journal of Pathology 27(1), 19–21 (1998).PubMedGoogle Scholar
  3. 3.
    M. Benderdour, K. Hess, M. D. Gadet, B. Dousset, P. Nabet., and F. Bellville, Effect of boric acid solution on cartilage metabolism. Biochim. Biophys. Res. Commun. 234(1), 263–268 (1997).CrossRefGoogle Scholar
  4. 4.
    C. D. Hunt, J. L. Herbel, and J. P. Idso, Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy subtract utilization and mineral metabolism in the chick, J. Bone Miner. Res. 9(2), 171–182 (1994).PubMedCrossRefGoogle Scholar
  5. 5.
    R. E. Newnham, Essentiality of boron for healthy bones and joints. Environ. Health Perspect. 102(7), 83–85 (1994).PubMedCrossRefGoogle Scholar
  6. 6.
    Zhang Shugong, Biological effect of germanium mixture and the research on Germanium drugs, in The 3rd National Proceedings on Germanium in China, pp. 19–21 (1995).Google Scholar
  7. 7.
    Li Hecheng and Song Xiangfang, Experimental therapeutic effect of Germanium-132 on osteoporosis, in The 3rd National Proceedings on Germanium in China, pp. 61–68 (1995).Google Scholar
  8. 8.
    Han Chun, Li Guangyuan, and Cao Shuguang. Assay of GSHpx, TBA, FFA in blood of children in Kashin-Beck disease. Chinese Journal of Controlling Endemic Diseases 2(2), 65–68 (1983).Google Scholar

Copyright information

© Humana Press Inc. 2000

Authors and Affiliations

  • Xu Peng
    • 1
  • Zeng Lingxia
    • 1
  • G. N. Schrauzer
    • 2
  • Guo Xiong
    • 1
  1. 1.Institute of Endemic Bone DiseasesXi’an Medical UniversityXi’anP. R. China
  2. 2.Biological Trace Element Research InstituteSan Diego

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