Abstract
A negative relationship between water hardness and cardiovascular mortality rate was demonstrated and became a source of interest regarding minerals and trace metals in the pathogenesis of atherosclerosis, cardiovascular diseases, and arterial hypertension. Higher incidences of sudden death, cerebrovascular diseases, arterial hypertension, and coronary heart disease have been reported in soft water areas. A major research effort has been devoted to the problem in an attempt to find a protective factor in hard water or a detrimental factor or element in soft water. The roles of calcium, magnesium, cobalt, lithium, vanadium, silicon, manganese, and copper have been considered potentially beneficial, whereas those of cadmium, lead, silver, zinc, and antimony have been considered potentially harmful. Cobalt and zinc have been attributed both roles. In the present article, the role of trace quantities of several elements in mineral water in the etiopathogenesis of primary arterial hypertension is reviewed.
This is a preview of subscription content, access via your institution.
References
G. W. Comstock, Water hardness and cardiovascular diseases, Am. J. Epidemiol. 110, 375–400 (1979).
J. Genest, O. Kuchel, P. Hamet, and M. Cantin, Hypertension, McGraw-Hill, New York (1983).
D. R. Peterson, D. J. Thompson, and J. N. Nam, Water hardness, arteriosclerotic heart disease and sudden death, Am. J. Epidemiol. 92, 90–93 (1970).
H. A. Schroeder, The role of trace elements in cardiovascular diseases, Med. Clin. North Am. 58, 381–196 (1974).
H. A. Schroeder and L. A. Kriemer, Cardiovascular mortality, municipal water and corrosion, Arch. Environ. Health 28, 303–311 (1974).
W. R. Harlan, J. R. Landis, R. L. Schmouder, N. G. Goldstein, and L. C. Harlan, Blood lead and blood pressure, JAMA 253, 530–534 (1985).
T. Oshima and E. W. Young, Systemic and cellular calcium metabolism and hypertension, Semin. Nephrol. 15, 496–503 (1995).
P. Saltman, Trace elements and blood pressure, Ann. Intern. Med. 98, 823–827 (1983).
N. V. Davydenko, I. P. Smirnova, E. A. Kvasha, I. M. Gorbas, and A. V. Koblianskaia, Interrelationships between dietary intake of minerals and prevalence of hypertension, Vopr. Pitan. 6, 17–19 (1995).
N. V. Davydenko, I. P. Smirnova, E. A. Kvasha, and I. M. Gorbas, The relationship between the cooper and zinc intake with food and the prevalence of ischemic heart disease and its risk factors, Lik. Sprava 5–6, 73–77 (1995).
J. Staessen, F. Sartor, and H. Roels, The association between blood pressure, calcium and other divalent cations: a population study, J. Hum. Hypertens. 5, 485–494 (1991).
S. Tubek, Znaczenie cynku w regulacji ciœnienia têtniczego i etiopatogenezie nadciœnienia, Post. Med. Klin. Doœw 3, 411–415 (1994) (in Polish).
E. K. Gilbert D'Angelo, H. A. Singer, and C. M. Rembold, Magnesium relaxes arterial smooth muscle by decreasing intracellular Ca++ without changing intracellular Mg++, J. Clin. Invest. 89, 1988–1994 (1992).
J. Durlach, Magnez w Praktyce Klinicznej, PZWL, Warszawa, (1991) (in Polish).
S. Ripa and R. Ripa, Zinc and arterial pressure, Minerva Med. 85, 455–459 (1994).
H. Dalheim, C. L. White, and J. Rothemund, Effect of zinc depletion on angiotensin I-converting enzyme in arterial walls and plasma of the rat, Miner. Electrolyte Metab. 15, 125–128 (1989).
J. Cortijo, J. V. Espligues, and B. Serria, Zinc as a calcium antagonist; a pharmacological approach in strips of rat aorta, IRCS Med. Sci. Cancer 13, 292–293 (1985).
B. L. Vallee and K. H. Falchuk, The biochemical basis of zinc physiology, Physiol. Rev. 73, 79 (1993).
D. Kromhout, A. A. E. Wibowo, and R. F. M. Herber, Trace metals and coronary heart disease risk indicators in 152 elderly men (The Zutphen Study), Am. J. Epidemiol. 122, 378–385 (1985).
J. Guillemant, H.-T. Le, C. Accarie, et al., Mineral water as source of dietary calcium: acute effects on parathyroid function and bone resorption in young men, Am. J. Clin. Nutr. 71, 999–1002 (2000).
J. Thomas, J-M. Millot, S. Sebille, et al., Free and total magnesium in lymphocytes of migraine patients. Effect of magnesium-rich mineral water intake, Clin. Chim. Acta 295, 63–75 (2000).
R. Rylander and M. J. Arnaud, Mineral water intake reduces blood pressure among subjects with low urinary magnesium and calcium levels, BMC Public Health 4, 56–63 (2004).
Author information
Authors and Affiliations
Additional information
An erratum to this article is available at http://dx.doi.org/10.1007/BF02686004.
Rights and permissions
About this article
Cite this article
Tubek, S. Role of trace elements in primary arterial hypertension. Biol Trace Elem Res 114, 1–5 (2006). https://doi.org/10.1385/BTER:114:1:1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/BTER:114:1:1