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Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation

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Abstract

The aim of our study was to assess the blood concentrations of some trace elements and melatonin (MLT) in patients with intervertebral disc herniation (IDH) and to investigate the interaction of histological and biochemical degeneration findings with aging. The present study was carried out on 13 subjects (8 women and 5 men) diagnosed with IDH. They were divided into three groups according to their ages. Nighttime serum MLT, zinc (Zn), and magnesium (Mg) levels were determined in all patients. In addition, computed tomography (CT) scan of the brain and magnetic resonance imaging examination of the lumbar spine were obtained in this study. The Zn level and Zn/Mg ratio showed a decline in patients with IDH with aging, whereas the serum Mg level and tissue hydroxyproline content increased. A positive correlation between serum Zn and MLT concentrations was found (r=0.104, p=0.734). In addition, there was a positive correlation between serum Zn level and Zn/Mg ratio (r=0.835 and p<0.01), and a negative correlation between serum Mg level and Zn/Mg ratio (r=−0.571, p<0.05). On CT study, both volume percentage of calcified pineal gland and density of calcification were found to increase progressively with advancing age. The results of semiquantitative evaluation of disc tissues of patients with IDH for histological degeneration findings showed that 66.7% of discs treated had slight degeneration in younger age group, but 75.0% and 100% of discs had moderate or marked degeneration in older age groups. Our data indicated that there is a close relationship between MLT and Zn or Mg levels in the serum samples of patients with IDH, and the levels of these elements might be affected by the presence of degeneration process and serum MLT level, or vice versa.

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Authors and Affiliations

  1. Department of Neurosurgery, College of Medicine, Adnan Menderes University, Aydin, Turkey

    Mehmet Turgut & Orhan Akyüz

  2. Department of Biochemistry, College of Medicine, Adnan Menderes University, Aydin, Turkey

    Çiğdem Yenisey & Tuncay Biçakçi

  3. Department of Radiology, College of Medicine, Adnan Menderes University, Aydin, Turkey

    Yelda Öszunar

  4. Department of Pathology, College of Medicine, Adnan Menderes University, Aydin, Turkey

    Muhan Erkuş

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  1. Mehmet Turgut
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  2. Çiğdem Yenisey
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  4. Yelda Öszunar
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Turgut, M., Yenisey, Ç., Akyüz, O. et al. Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation. Biol Trace Elem Res 109, 123–134 (2006). https://doi.org/10.1385/BTER:109:2:123

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  • DOI: https://doi.org/10.1385/BTER:109:2:123

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