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Copper, selenium, and zinc concentrations in human milk during the first three weeks of lactation

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Abstract

Human milk samples were analyzed by neutron activation analysis (NAA) for three essential trace elements (Cu, Se, and Zn). Mothers' milk samples were collected from 25 lactating mothers from the Central Hospital, Tripoli, Libya. The average concentration level of Cu, Se, and Zn declined from 0.84±0.06 mg/L, 104±9.46 μg/L, and 16.1±2.67 mg/L at d 0 to 0.39±0.045 mg/L, 41.8±6.66 μg/L, and 4.95±1.3 mg/L, respectively, at d 20 of lactation. Copper and Zn levels in the Libyan mothers' milk were in agreement with reported levels from other countries, whereas Se was at a higher level. The Cu daily intake level is slightly higher than the RDA (Recommended Daily Allowance) value. Selenium and Zn have higher intake levels than the RDA values but within the tolerable upper intake levels.

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References

  1. E. Cortes, N. Gras, L. Munor, and V. Cassorla, A study of some trace elements in infant foods, J. Radioanal. Nucl. Chem. 69(1–2), 40 (1982).

    Google Scholar 

  2. World Health Organization (WHO) Trace Elements in Human Nutrition, Technical Report Series No. 532, WHO, Geneva (1973).

    Google Scholar 

  3. E. J. Underwood, Trace Elements in Human and Animal Nutrition, 3rd ed., Academic, New York (1971).

    Google Scholar 

  4. H. J. M. Bowen, Environmental Chemistry of the Elements, Academic, New York (1979).

    Google Scholar 

  5. R. M. Parr, Trace elements in human milk, IAEA Bull. 25(2), 7 (1983).

    CAS  Google Scholar 

  6. H. Benemarjia, H. Robbernecht, and H. Deelstra, Copper, zinc, and selenium concentrations in milk from middle-class women in Burundi (Africa) throughout the first months of lactation, Sci. Total Environ. 164, 161–174 (1995).

    Article  Google Scholar 

  7. L. Perrone, L. Di Palma, R. Di Toro, G. Gialananella, and R. Moro, Interaction of trace elements in a longitudinal study of human milk from full-term and pro-term mothers, Biol. Trace Element Res. 41, 321–330 (1994).

    CAS  Google Scholar 

  8. E. Vuori and P. Kuitunen, The concentrations of copper and zinc in human milk, Acta Paediatr. Scand. 68, 33–37 (1979).

    PubMed  CAS  Google Scholar 

  9. M. Krachler, F. Shi Li, E. Rossipal, and K. J. Irgolic, changes in the concentrations of trace elements in human milk during lactation, J. Trace Elements Med. Biol. 12, 159–176 (1998).

    CAS  Google Scholar 

  10. D. Silvestre, C. Martinez-Costa, M. J. Lagarda, J. Brines, R. Farre, and G. Clemente, Copper, iron, and zinc contents in human milk during the first three months of lactation, Biol. Trace Elements Res. 80, 1–11 (2001).

    Article  CAS  Google Scholar 

  11. J. J. B. Andersor, Minerals, in Krause's Food, Nutrition, & Diet Therapy, 11th ed., Saunders, Philadelphia, pp. 120–163 (2004).

    Google Scholar 

  12. American Academy of Pediatrics, Breast-feeding, a commentary in celebration of the International Year of the Child, 1979, Pediatrics 62, 591–601 (1979).

    Google Scholar 

  13. R. R. Anderson, Comparison of trace elements in milk of four species, J. Dairy Sci. 75, 3050–3055 (1992).

    Article  PubMed  CAS  Google Scholar 

  14. J. Arnaud, A. Favier, and J. Alary, Determination of zinc in human milk by electro thermal atomic absorption spectrometry, J. Anal. Atomic Spectrom. 6, 647–652 (1991).

    Article  CAS  Google Scholar 

  15. B. Debski, T. P. Zarski, and J. A. Milner, Selenium content and distribution in bovine and human milk from different regions from Poland, J. Vet. Med, Assoc. 39, 313–318 (1992).

    Article  CAS  Google Scholar 

  16. B. A. Zachara, U. Trafikowska, M. Czerwionka-Szaflarska, and E. Sobkowiak, Selenium and selenoenzyme-glutathione peroxidase—in human milk during different stages of lactation. A preliminary study, Pediatr. Pol. 69, 839–844 (1994).

    Google Scholar 

  17. PATI, Program of routine gamma analysis, Report No. 83-10-04, Tajoura Nuclear Research Center, Tripoli, Libya (1983).

    Google Scholar 

  18. I. A. Ashur, N. N. Dogadkin, W. M. Markus, and A. H. M. A. Hannan, Determination of trace elements in milk samples, in Proceedings of Seventh International Symposium on Trace Elements in Man and Animals (TEMA-7), pp. 25-4–25-6 (1990).

  19. G. V. Iyengar, K. Kasperek, L. E. Feinendegen, Y. X. Wang, and H. Weese, Determination of Co, Cu, Fe, Hg, Mn, Sb, Se, and Zn in milk sample, Sci. Total Environ. 24, 267–274 (1982).

    Article  PubMed  CAS  Google Scholar 

  20. R. Dybczynski, A. Vegalia, and O. Suchny, Report of the intercomparison run A-11 for the determination of inorganic constituents of milk powder, IAEA/RL/68 (1980).

  21. P. B. Moser and R. D. Reynolds, Dietary zinc intake and zinc cocncentrations of plasma, erythrocytes, and breast milk in antepartum and postpartum lactating and nonlactating woman, a longitudinal study, Am. J. Clin. Nutr. 38, 101–108 (1983).

    PubMed  CAS  Google Scholar 

  22. M. Ohatke and T. Tamura, Changes in zinc and copper concentrations in breast milk and blood of Japanese women during lactation, J. Nutr. Sci. Vitaminol. 39, 189–200 (1993).

    Google Scholar 

  23. W. Wasowicz, J. Gromadzinska, K. Szarm, K. Rydzynski, J. Cieslak, and Z. Pietrzak, Selenium, zinc, and copper concentrations in the blood and milk of lactating women, Biol. Trace Element Res. 79, 221–233 (2001).

    Article  CAS  Google Scholar 

  24. K. T. Suzuki, H. Tamagawa, S. Hirano, E. Kobayashi, K. Takahashi, and N. Shimojo, Changes in element concentration and distribution in breast milk fractions of healthy lactating mother, Biol. Trace Element Res. 28, 109–121 (1991).

    Article  CAS  Google Scholar 

  25. M. S. Alaejos and C. D. Romero, Selenium in human lactation, Nutr. Rev. 53, 159–166 (1995).

    Article  Google Scholar 

  26. A. Kirksey, J. A. Ernst, J. L. Roepke, and T.-L. Tsai, Influence of mineral intakes and use of oral contratceptives before pregnancy on the mineral content of human colostrums and more mature milk, Am. J. Clin. Nutr. 32, 30–39 (1979).

    PubMed  CAS  Google Scholar 

  27. L. A. Vaughan, C. W. Weber, and S. R. Kemberling, Longitudial changes in the mineral content of human milk, Am. J. Clin. Nutr. 32, 2301–2306 (1979).

    PubMed  CAS  Google Scholar 

  28. E. Vuori, S. M. Makinen, R. Kara, and P. Kuitunen, The effect dietary intakes of copper, iron, manganese, and zinc on the trace element content of human milk, Am. J. Clin. Nutr. 33, 227–231 (1980).

    PubMed  CAS  Google Scholar 

  29. J. Kumpulainen, E. Vuori, and M. A. Siimes, Effect of maternal dietary selenium intake on selenium levels in breast milk, Int. J. Vitam. Nutr. Res. 54, 252–256 (1984).

    Google Scholar 

  30. J. Kumpulainen, L. Salmenpara, and M. A. Siimes, Selenium status of exclusively breast-fed infants as influenced maternal organic or inorganic selenium supplementation, Am. J. Clin. Nutr. 42, 29–35 (1985).

    Google Scholar 

  31. J. Kumpulainen, L. Salmenpara, M. A. Siimes, P. Koivistoinen, J. Lehto, and J. Perheetupa, Formula feeding results in lower selenium status than breast-feeding or selenium supplemented formula feeding: a longitudinal study, Am. J. Clin. Nutr. 45, 49–53 (1987).

    PubMed  CAS  Google Scholar 

  32. M. A. Funk, L. Hamlin, M. F. Picciano, A. Prentice, and J. A. Milner, Milk selenium of rural African women: influence of maternal nutrition parity, and length of lactation, Am. J. Clin. Nutr. 51, 220–224 (1990).

    PubMed  CAS  Google Scholar 

  33. E. Bratter, V. E. Negretti de Bratter, W. G. Jaffe, and H. M. Castellano, Selenium status of children living in seleniferous areas of Venezuela, J. Trace Elements Electrolytes Health. Dis. 5, 269–270 (1991).

    CAS  Google Scholar 

  34. P. Ratter, V. E. Negretti de Bratter D. Gawlik, W. Oliver, N. Alvarez, and W. Jaffe, Selenium in human monitors related to the regional dietary intake levels in Venezuela, J. Trace Elements Electrolytes Health Dis. 7, 111–112 (1993).

    Google Scholar 

  35. H. Robberrecht, E. Roekens, M. Van. Callie-Betrabnd, H. Deelstra, and R. Clara, Longitudinal study of the selenium content in human breast milk in Belgium, Acta Paediatr. Scand. 74, 254–258 (1985).

    Google Scholar 

  36. C. E. Johnson, A. M. Smith, G. M. Chan, and L. J. Moyer-Mileur, Selenium status of terms infants fed human milk or selenite-supplemented soy formula, J. Pediatr. 122, 739–741 (1993).

    Article  PubMed  CAS  Google Scholar 

  37. R. M. Parr, E. M. DeMayer, V. G. Iyengar, et al., Minor and trace elements in human milk from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Ziare, Resukts from WHO/IAEA joint project, Biol. Trace Element Res. 29(1), 51–75 (1991).

    Article  CAS  Google Scholar 

  38. R. Bernfangstam, Studies in blood zinc—a clinical and experimental investigation into the zinc content of plasma and blood corpuscles with specific reference to infants, Acta Paediatr. 41, 105–109 (1952).

    Google Scholar 

  39. R. Shrimpton, H. A. Marinho, Y. S. Rocha, and F. H. Alencar, Zinc supplementation in urban Amazonian mothers: concentration of zinc and retinol in maternal serum and milk, Proc. Nutr. Soc. 42, 122A (1983).

    Google Scholar 

  40. M. F. Picciano and H. A. Guthrie, Copper, iron, and zinc content of mature milk, Am. J. Clin. Nutr. 29, 242–254 (1976).

    PubMed  CAS  Google Scholar 

  41. Institute of Medicine, Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Elements, Food and Nutrition Board, National Academy of Sciences, Washington, DC (2001). Available from http://www.nin.ca/En/pdf/dri.pdfurl (accessed 2001).

    Google Scholar 

  42. H. J. M. Bowen, Trace Elements in Biochemistry, Academic, New York (1966).

    Google Scholar 

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Hannan, M.A., Dogadkin, N.N., Ashur, I.A. et al. Copper, selenium, and zinc concentrations in human milk during the first three weeks of lactation. Biol Trace Elem Res 107, 11–20 (2005). https://doi.org/10.1385/BTER:107:1:011

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  • DOI: https://doi.org/10.1385/BTER:107:1:011

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