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Plasma and erythrocyte selenium and glutathione peroxidase activity in preterm infants at risk for bronchopulmonary dysplasia

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Abstract

The purpose of this study was to examine the relationships between selenium status, as measured by plasma and erythrocyte selenium and glutathione peroxidase (GPx) activity, and other postnatal factors, including selenium intake, gestational age, and oxygen dependence in preterm infants at risk for bronchopulmonary dysplsia. Eighteen preterm infants of 30 wk gestational age or less were included. At postnatal wk 1 and 4, selenium concentrations and GPx activity were measured and oxygen dependence and daily selenium intakes were determined from the medical chart. Plasma and erythrocyte selenium concentrations decreased from wk 1 to wk 4, whereas erythrocyte GPx activity increased. Increased selenium intakes during wk 1 were associated with increased erythrocyte GPx activity at both time-points, as well as a decreased need for supplemental oxygen on d 28. Preterm infants display increasing erythrocyte GPx activity despite declines in plasma and erythrocyte selenium. GPx activity might be enhanced by very early selenium supplementation.

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Authors and Affiliations

  1. The Ohio State University College of Nursing, 1585 Neil Avenue, 43210, Columbus, OH

    Anne M. Mentro

  2. Department of Human Nutrition, The Ohio State University, 1787 Neil Avenue, 43210, Columbus, OH

    Anne M. Smith

  3. The University of Utah School of Medicine, 50 N. Medical Drive, 84132, Salt Lake City, UT

    Laurie Moyer-Mileur

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Mentro, A.M., Smith, A.M. & Moyer-Mileur, L. Plasma and erythrocyte selenium and glutathione peroxidase activity in preterm infants at risk for bronchopulmonary dysplasia. Biol Trace Elem Res 106, 97–106 (2005). https://doi.org/10.1385/BTER:106:2:097

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  • DOI: https://doi.org/10.1385/BTER:106:2:097

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