Abstract
The effects of zinc deficiency and supplementation on plasma leptin levels were studied in Sprague-Dawley rats. After 6 wk on a zinc-deficient diet containing 0.65 ppm Zn/g, the mean body weight was significantly lower than that of normal or zinc-supplemented rats, which showed no difference among them. The plasma leptin and zinc levels were lowest in zinc-deficient animals and highest in those that received a normal diet and daily intraperitioneal injections of 3 mg Zn/kg. These results indicate that zinc deficiency leads to a significant inhibition in plasma leptin levels, whereas zinc supplementation significantly increases plasma leptin.
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Baltaci, A.K., Mogulkoc, R. & Halifeoglu, I. Effects of zinc deficiency and supplementation on plasma leptin levels in rats. Biol Trace Elem Res 104, 41–46 (2005). https://doi.org/10.1385/BTER:104:1:041
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DOI: https://doi.org/10.1385/BTER:104:1:041