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Selenium level in benign and cancerous prostate

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Abstract

The dietary microelement selenium (Se) has been proposed as a potential chemopreventive agent for prostate cancer. This element is present in various amounts in all tissues. Little information is available on Se level in patients with prostate gland disorders. The levels of Se in prostatic gland of patients with prostate cancer, benign prostate hyperplasia, and healthy controls were examined. The Se level for benign prostate hyperplasia (156±30.6 ng/g) was the same as in the control group (157±26.0 ng/g), but in the gland of prostate cancer patients (182±34.1 ng/g wet weight), the Se level was significantly (p<0.01) higher than in both healthy controls and benign prostate hyperplasia. Thus, the Se level in human healthy controls is lower than in kidney and liver but higher compared with other tissues.

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Authors and Affiliations

  1. Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland

    Bronislaw A. Zachara & Wojciech Wasowicz

  2. Department of Biochemistry, Medical University, Bydgoszcz, Poland

    Karolina Szewczyk-Golec

  3. Department of Urology, Medical University, Bydgoszcz, Poland

    Zbigniew Wolski & Janusz Tyloch

  4. Department of Clinical Patomorphology, Medical University, Bydgoszcz, Poland

    Zdzislaw Skok

  5. Department of Forensic Medicine, Medical University, Bydgoszcz, Poland

    Elzbieta Bloch-Boguslawska

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  1. Bronislaw A. Zachara
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  2. Karolina Szewczyk-Golec
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  3. Zbigniew Wolski
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  7. Wojciech Wasowicz
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Zachara, B.A., Szewczyk-Golec, K., Wolski, Z. et al. Selenium level in benign and cancerous prostate. Biol Trace Elem Res 103, 199–206 (2005). https://doi.org/10.1385/BTER:103:3:199

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  • DOI: https://doi.org/10.1385/BTER:103:3:199

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