The effect of oral administration of nickel(II) chloride on iron content in serum and certain body organs of rats was investigated. The male adult rats were given 300 and 1200 ppm Ni in drinking water for 90 d. The iron content in serum, liver, kidney, lung, spleen, and brain was analyzed 30 and 90 d postexposure. The hemoglobin, hematocrit, and body and organ weights were also measured. Nickel given in drinking water led to a pronounced increase in iron content in serum and the liver, as compared to control rats. This effect was related to Ni concentration in the water. There was not great time-dependent difference in the iron content as a response to continuous nickel treatment, except the lung of 1200-ppm Ni-treated rats. In relation to hematological parameters, Ni supplementation did not affect any of them. Body weight significantly decreased, and lung weight was significantly increased in 1200-ppm Ni-treated rats. The results of this study indicate that nickel ingestion (300 and 1200 ppm in the drinking water) induces the iron uptake by serum and some organs of rats. The highest amount of iron was found in the liver of all exposed animals, and the time-dependent difference in iron content was observed in the lung of 1200-ppm Ni-treated rats.
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M. Athar, S. K. Hasan, and R. C. Srivastava, Evidence for the involvement of hydroxyl radicals in nickel mediated enhancement of lipid peroxidation: implications for nickel carcinogenesis, Biochem. Biophys. Res. Commun. 147, 1276–1281 (1987).
M. Misra, R. E. Rodriquez, and K. S. Kasprzak, Nickel induced lipid peroxidation in the rat: correlation with nickel effect on antioxidant defense systems, Toxicology 64, 1–17 (1990).
Ch. Y. Chen, Y. L. Huang, and T. H. Lin, Lipid peroxidation in liver of mice administrated with nickel chloride. With special reference to trace elements and antioxidants. Biol. Trace Element Res. 61, 193–205 (1998).
P. D. Whanger, Effects of dietary nickel on enzyme activities and mineral contents in rats, Toxicol. Appl. Pharmacol. 25, 323–331 (1973).
B. Elsenhans, G. Schmolke, K. Kolb, J. Stokes, and W. Forth, Metal-metal interactions among dietary toxic and essential trace metals in the rat, Ecotoxicol. Environ. Safety 14, 275–287 (1987).
J. S. Oosting, A. G. Lemmens, G. J. Van Den Berg, and A. C. Beynen, Iron, copper, and zinc status in rats fed supplemental nickel, Biol. Trace Element Res. 31, 63–70 (1991).
J. Cartana, L. Arola, and A. Mas, Effects of acute nickel toxicity upon plasma and liver metal homeostasis as a function of sex, Toxicology 69, 133–141 (1991).
WHO, Environmental Health Criteria, Nickel, World Health Organization, Geneva, Vol. 108 (1991).
M. Cempel and K. Janicka, Distribution of nickel, zinc and copper in rats organs after oral administration of nickel(II) chloride, Biol. Trace Element Res. 90, 215–226 (2002).
K. Janicka and M. Cempel, Lipid peroxidation and selected antioxidants in rat liver after oral exposure to nickel(II) chloride, Bromat. Chem. Toksykol. 34, 291–295 (2001).
R. H. Thompson and W. J. Blacchflower, Wet-ashing apparatus to prepare biological materials for atomic absorption spectrophotometry, Lab. Pract. 20, 859–861 (1971).
M. Pinta, Absorpcyjna Spektrometria Atomowa. Zastosowania w Analizie Chemicznej, PWN, Warszawa (1977).
M. P. Dieter, C. W. Jameson, A. N. Tucker, et al., Evaluation of tissue disposition, myelopoietic, and immunologic responses in mice after long-term exposure to nickel sulfate in the drinking water, J. Toxicol. Environ. Health 24, 357–372 (1988).
J. A. Knight, M. R. Plowman, S. M. Hopfer, and F. W. Sunderman, Pathological reactions in lung, liver, thymus, and spleen of rats after subacute parenteral administration of nickel sulfate, Ann. Clin. Lab. Sci. 21, 275–283 (1991).
M. Comporti, Serial review: iron and cellular redox status, Free Radical Biol. Med. 32, 565–567 (2002).
S. J. Stohs and D. Bagchi, Oxidative machanisms in the toxicity of metal ions, Free Radical Biol. Med. 18, 321–336 (1995).
F. W. Sunderman, A. Marzouk, S. M. Hopfer, O. Zaharia, and M. C. Reid, Increased lipid peroxidation in tissues of nickel chloride-treated rats, Ann. Clin. Lab. Sci. 15, 229–236 (1985).
J. J. Clary, Nickel chloride-induced metabolic changes in the rat and guinea pig, Toxicol. Appl. Pharmacol. 31, 55–65 (1975).
J. Tallkvist and H. Tjalve, Effect of dietary iron-deficiency on the disposition of nickel in rats, Toxicol. Lett. 92, 131–138 (1997).
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Cempel, M. Effect of nickel(II) chloride on iron content in rat organs after oral administration. Biol Trace Elem Res 102, 189 (2004). https://doi.org/10.1385/BTER:102:1-3:189
- nickel chloride
- rat organs