Abstract
To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the ordinary dissection, mitral valves, lower parts of the interventricular septa, and terminal crests containing the sinoatrial nodes were resected and the element contents were determined by inductively coupled plasma-atomic emission spectrometry. The interventricular septa and sinoatrial nodes were used to compare with the mitral valves. With regard to the mitral valve, it was found that extremely significant correlations were found among the contents of Ca, P, Mg, and Na, but no significant correlations were found between the contents of S and elements such as Ca, P, or Mg. Regarding the interventricular septum, it was found that an extremely significant correlation was found between P and S contents; very significant correlations were found between Ca and Mg contents and between Mg and S contents; and a significant correlation was found between P and Mg contents. However, no significant correlation was found between Ca and P contents in the interventricular septa. In the terminal crest containing the sinoatrial node, significant correlations were found among the contents of Ca, P, Mg, and S. The present study revealed that with regard to the relationships among element contents, the compositional change of the mitral valve was intermediate between those of the thoracic aorta and the interventricular septum.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. A. Simon and S. F. Liu, Calcification of the mitral valve annulus and its relation to functional valvular disturbance, Am. Heart J. 48, 497–505 (1954).
A. Pomerance, Pathological and clinical study of calcification of the mitral ring, J. Clin. Pathol. 23, 354–361 (1970).
J. D. Cooksey, B. M. Parker, and C. S. Weldon, Atrial septal defect and calcification of the tricuspid valve, Br. Heart J. 32, 409–411 (1970).
S. Tohno, Y. Moriwake, Y. Tohno, T. Minami, F. Nishiwaki, M. Utsumi, et al., Age-related changes of element contents in human mitral and tricuspid valves, Biol. Trace Element Res. 70, 137–147 (1999).
Y. Tohno, S. Tohno, T. Minami, Y. Moriwake, F. Nishiwaki, K. Hashimoto, et al., Differences in accumulation of elements in human cardiac valves, Biol. Trace Element Res. 77, 107–118 (2000).
E. R. Mohler, Are atherosclerotic processes involved in aortic-valve calcification? Lancet 356, 524–525 (2000).
S. Tohno, Y. Tohno, Y. Moriwake, C. Azuma, Y. Ohnishi, and T. Minami, Compositional changes of the aortic valve similar to the artery with aging, Biol. Trace Element Res., in press.
Y. Tohno, S. Tohno, H. Matsumoto, and K. Naito, A trial of introducing soft X-ray apparatus into dissection practice for students, J. Nara Med. Assoc. 36, 365–370 (1985).
Y. Tohno, S. Tohno, T. Minami, M. Ichii, Y. Okazaki, M. Utsumi, et al., Age-related changes of mineral contents in human thoracic aorta and in the cerebral artery, Biol. Trace Element Res. 54, 23–31 (1996).
Y. Tohno, S. Tohno, Y. Moriwake, C. Azuma, Y. Ohnishi, and T. Minami, Accumulation of calcium and phosphorus accompanied by increase of magnesium and decrease of sulfur in human arteries, Biol. Trace Element Res. 82, 9–19 (2001).
W. C. Roberts, J. K. Perloff, and T. Costantino, Severe valvular aortic stenosis in patients over 65 years of age: a clinico-pathologic study, Am. J. Cardiol. 27, 497–506 (1971).
B. F. Waller and W. C. Roberts, Cardiovascular disease in the very elderly: analysis of 40 necropsy patients aged 90 years or over, Am. J. Cardiol. 51, 403–421 (1983).
W. C. Roberts and J. K. Perloff, Mitral valvular disease: a clinico-pathologic survey of the conditions causing the mitral valve to function abnormally, Ann. Intern. Med. 77, 939–975 (1972).
G. R. Schott, M. N. Kotler, W. R. Parry, and B. L. Segal, Mitral annular calcification: clinical and echocardiographic correlations, Arch. Intern. Med. 137, 1143–1150 (1977).
R. S. Kirk and J. G. B. Russell, Subvalvular calcification of mitral valve, Br. Heart J. 31, 684–692 (1969).
S. Sell and R. E. Scully, Aging changes in the aortic and mitral valves, Am. J. Pathol. 46, 345–355 (1965).
P. K. Fulkerson, B. M. Beaver, J. C. Auseon, and H. L. Graber, Calcification of the mitral annulus: etiology, clinical associations, complications and therapy, Am. J. Med. 66, 967–977 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tohno, Y., Tohno, S., Satoh, H. et al. Compositional changes of human mitral valves with aging. Biol Trace Elem Res 88, 203–213 (2002). https://doi.org/10.1385/BTER:88:3:203
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/BTER:88:3:203