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Primary hyperparathyroidism

Medical management

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Clinical Reviews in Bone and Mineral Metabolism Aims and scope Submit manuscript

Summary and Conclusions

Primary hyperparathyroidism remains a controversial disease, in part because of continuing uncertainty about its effects on neuropsychiatric function and risk of vascular events. Several observational studies have now demonstrated low rates of morbid events in patients with untreated, mild PHPT. It is this author's opinion that patients with mild PHPT who do not have recognized complications of the disease (renal stones or osteopenia) may be managed expectantly, with annual biochemical review and less frequent bone density assessments, until more conclusive data are available on other putative associations. Osteopenic patients with PHPT can be effectively treated either with surgery or antiresorptive agents, although the presence of renal stones at diagnosis is a clear indication for surgical intervention. Studies of the effects of calcimimetic agents and new vitamin D analogs may increase the range and efficacy of therapies available for medical management of PHPT.

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Authors and Affiliations

  1. Department of Medicine, University of Auckland, Auckland, New Zealand

    Andrew Grey MBChB, FRACP

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  1. Andrew Grey MBChB, FRACP
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Grey, A. Primary hyperparathyroidism. Clinic Rev Bone Miner Metab 1, 35–42 (2002). https://doi.org/10.1385/BMM:1:1:35

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