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Hypercalcemia

Differential diagnosis and investigation

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Clinical Reviews in Bone and Mineral Metabolism Aims and scope Submit manuscript

Conclusions

The etiology of hypercalcemia can be clearly defined in the majority of patients by following a simple diagnostic algorithm outlined in Fig. 1. The performance and interpretation of analytical methods, now routinely available within diagnostic laboratories, has improved considerably within the last decade. These developments have improved our ability to diagnose the cause of hypercalcemia with confidence. Consequently, it should be possible to determine whether the hypercalcemia, in an individual patients, is mediated principally by the bowel, kidney, or bone compartment. Armed with this information and with the advent of novel, more selective therapeutic agents, treatment prescriptions in the future may be more appropriately tailored to each individual case.

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Authors and Affiliations

  1. Department of Core Clinical Pathology and Biochemistry, Royal Perth Hospital, Perth, Western Australia

    Paul Glendenning PhD, FRACP, Bronwyn G. A. Stuckey FRACP & Samuel D. Vasikaran MD, FRCPA

  2. Department of Endocrinology and Diabetes, Keogh Institute for Medical Research, Sir Charles Gairdner Hospital, Perth, Western Australia

    Bronwyn G. A. Stuckey FRACP & Samuel D. Vasikaran MD, FRCPA

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  1. Paul Glendenning PhD, FRACP
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Glendenning, P., Stuckey, B.G.A. & Vasikaran, S.D. Hypercalcemia. Clinic Rev Bone Miner Metab 1, 11–24 (2002). https://doi.org/10.1385/BMM:1:1:11

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