Skip to main content
SpringerLink
Log in

The effect of hydroxyurea and mitomycin-C to prevent postoperative adhesion and fibrosis after hang-back recession in rabbits

  • Original Article
  • Published:
Annals of Ophthalmology

Abstract

Purpose

To investigate a way to prevent postoperative adhesion and fibrosis after hang-back recession surgery, an animal study was carried out to evaluate the effect of mitomycin-C (MMC) and hydroxyurea (HU) on this procedure.

Methods

A prospective, masked-observer, controlled study was performed in New Zealand rabbits. Bilateral hang-back recession of superior and inferior rectus muscle was performed and MMC and HU were applied 5 minutes between muscle-sclera and muscle-conjunctiva with a sponge (groups I and II), whereas other eyes of these rabbits were reserved as control group (group III). In this study, the degree of postoperative adhesion, fibrosis, and vascularization of conjunctiva were recorded and compared.

Results

In groups I and II, the records of postoperative adhesion and fibrosis were found to be significantly lower than in the control group. The new insertion line was more regular in groups I and II. Histopathological examination of these muscles revealed decreased fibrosis of perimuscular connective tissue in eye groups I and II.

Conclusion

This article suggests that HU and MMC can help to reduce postoperative adhesion, fibrosis, and vascularization of conjunctiva in rabbits that underwent hang-back recession surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dunlap EA. Surgery of muscle adhesion and effects of multiple operations. Br J Ophthalmol. 1974;58:307–312.

    PubMed  CAS  Google Scholar 

  2. Cruz OA, Matkovich L. Effects of intraoperative topical mitomycin-C on strabismus surgery in the rabbit: a preliminary study. Ophthalmic Surg. 1995;26:237–240.

    PubMed  CAS  Google Scholar 

  3. Othsuki H, Hasebe S, Okuda Y, Ogou T. Is mitomycin-C effective in preventing muscle migration after hang-back recession in a rabbit model?. Ophthalmologica 1997;211:373–379.

    Article  Google Scholar 

  4. Hwang JM, Chang BL. Combined effect of polytetrafluoroethylene and 5-fluorouracil on delayed adjustable strabismus surgery. J Pediatr Ophthalmol Strabismus. 2000;37:163–167.

    PubMed  CAS  Google Scholar 

  5. Yücel I, Bager G, Duranoglu Y, et al. The effect of hydroxyurea on rabbit subconjunctival fibroblast culture and use of hydroxyurea in rabbits after glaucoma filtration surgery. Ophthalmologica. 1999; 213:311–319.

    Article  PubMed  Google Scholar 

  6. Hwang JM, Chang BL. Combined effect of intercede and 5-fluorouracil on delayed adjustable strabismus surgery. Br J Ophthalmol. 1999;83:788–791.

    Article  PubMed  CAS  Google Scholar 

  7. Searl SS, Metz HS, Lindahl KJ. The use of sodium hyaluronate as a biologic sleeve in strabismus surgery. Ann Ophthalmol. 1987;19:259–268.

    PubMed  CAS  Google Scholar 

  8. Shodika MF. Use of silicone sheet for delayed adjustable strabismus surgery. Ophthalmic Surg. 1993;24:486–488.

    Google Scholar 

  9. Elsas FJ, Gowda DC, Urry DW. Synthetic polypepetide sleeve for strabismus surgery. J Pediatr Ophthalmol Strabismus. 1992;29:284–286.

    PubMed  CAS  Google Scholar 

  10. Huran JM, Chang BL. Ue of physical barriers for delayed adjustable strabismus surgery: the effect of intercede and polyglactin 910 mesh. Br J Ophthalmol. 1996;80:759–762.

    Google Scholar 

  11. Clorfeine GS, Parker WT. Use of healon in eye muscle surgery with adjustable sutures. Ann Ophthalmol. 1987;19:215–217.

    PubMed  CAS  Google Scholar 

  12. Oh SY, Park DW, Chang BL. The effect of mitomycin-C on the healing process in rabbit extraocular muscle surgery. Ophthalmologic Surg Lasers. 1999;30:305–309.

    CAS  Google Scholar 

  13. Cruz OA. Evaluation of mitomycin to limit postoperative adhesions in strabismus surgery. J Pediatr Ophthalmol Strabismus. 1996;33:89–92.

    PubMed  CAS  Google Scholar 

  14. Khaw PT, Doyle JW, Sherwood MB, et al. Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit. Ophthalmology 1993;100:367–372.

    PubMed  CAS  Google Scholar 

  15. Mora JS, Sprunger DT, Helveston EM, Evan AP. Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. J AAPOS. 1997;1:92–97.

    Article  PubMed  CAS  Google Scholar 

  16. Yaacobi Y, Hamed LM, Kaul KS, Fanous MM. Reduction of postoperative adhesions secondary to strabismus surgery in rabbits. Ophthalmic Surg. 1992;23:123–128.

    PubMed  CAS  Google Scholar 

  17. Nemet P, Stolovitch C. Delayed reattachment of extraocular muscle. Binoc Vis. 1989;4:23–22.

    Google Scholar 

  18. Oelsner G, Graebe RA, Pan S, et al. Chondroitin sulphate: a new intraperitoneal treatment for postoperative adhesion prevention in the rabbit. J Reprod Med. 1987;32:812–814.

    PubMed  CAS  Google Scholar 

  19. Glaubiger D, Ramu A. Antitumor antibiotics. In: Chabner BA, ed. Pharmacologie Principles of Cancer Treatment. Philadelphia, WB Saunders, 1982: pp. 407–410.

    Google Scholar 

  20. Chabner AC, Allegra JC, Curt AG, Calebresi P. Antineoplastic agents. In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. New York, Pergamon, 1996; pp. 1233–1287.

    Google Scholar 

  21. Knaap A, Heuer DK, Stern GA, et al. Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. Am J Ophthalmol. 1987;103:183–187.

    Google Scholar 

  22. Smith S, D’Amore PA, Dreyer EB. Comperative toxicity of mitomycin C and 5-fluorouracil in vitro. Am J Ophthalmol. 1994;118:332–337.

    PubMed  CAS  Google Scholar 

  23. Brooks SE, Riberio GB, Archer SM, et al. Fat adherence syndrome treated with intraoperative mitomycin C: a rabbit model. J Pediatr Ophthalmol Strabismus. 1996;33:21–27.

    PubMed  CAS  Google Scholar 

  24. Andreo LK, Uyemura MJ, Enzenauer RW. 5-fluorouracil reduces scarring after strabismus surgery. J Pediatr Ophthalmol Strabismus. 1997;34:107–110.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Akdeniz University, School of Medicine in Antalya, Turkey

    Yaşar Duranoğlu MD, Onursal Gözkaya MD & Meryem Altin MD

Authors
  1. Yaşar Duranoğlu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Onursal Gözkaya MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Meryem Altin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yaşar Duranoğlu MD.

Additional information

The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which include unlabeled, unapproved, or investigative products or devices.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Duranoğlu, Y., Gözkaya, O. & Altin, M. The effect of hydroxyurea and mitomycin-C to prevent postoperative adhesion and fibrosis after hang-back recession in rabbits. Ann Ophthalmol 37, 105–109 (2005). https://doi.org/10.1385/AO:37:2:105

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/AO:37:2:105

Keywords

Search

Navigation