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Retrofit of CD-6 (smith) impeller in fermentation vessels

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Abstract

We extended prior studies on the influence of impeller type on fermentation performance to include a novel low-power-number, high-efficiency radial flow impeller, the CD-6, possessing six curved blades on a disk turbine. Dual impeller combinations of CD-6/CD-6, CD-6/Maxflo T, and CD-6/HE-3 were compared with Rushton/Rushton and Maxflo T/Maxflo T base cases. Qualitative comparisons of unaerated and aerated power draw in both water and glycerol were conducted. These suggested minimal power drops with aeration for dual CD-6 impellers and hybrids containing the CD-6 impeller design. We also examined fermentation performance for Streptomyces and Glarea secondary metabolite fermentations. A qualitative comparison of the data suggested that dual CD-6 impellers and hybrids containing the CD-6 impeller design resulted in reasonable power draws, improved mass transfer rates with airflow increases, and acceptable peak titers. These arrangements may warrant further study under a wider range of production conditions.

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Abbreviations

D I :

Impeller diameter (tip to tip) (m)

D T :

Fermentor vessel diameter (m)

k L a :

Mass transfer coefficient (h−1)

N :

Impeller speed (s−1)

N p :

Newton or power number (P o/[ρN 3 D 5I ])

N Re :

Reynolds number for impeller (ND 2I ρ/μ)

P o :

Ungassed power draw (kW)

P g :

Gassed power draw (kW)

Q :

Volumetric gas flow rate (m3/s)

S :

Impeller spacing (m)

V L :

Ungassed liquid volume of tank (m3)

μ:

Viscosity (MPa·s)

ρ:

Liquid density (g/cm3)

References

  1. Buckland, B. C., Gbewonyo, K., DiMasi, D., Hunt, G., Westerfield, G., and Nienow, A. W. (1988), Biotechnol. Bioeng. 31, 737–742.

    Article  CAS  Google Scholar 

  2. Gbewonyo, K., DiMasi, D., and Buckland, B. C. (1986), Fluid Engineering Proceedings of the International Conference on Bioreactor Fluid Dynamics, Cambridge, England, pp. 281–299.

    Google Scholar 

  3. Nienow, A. W., Hunt, G., and Buckland, B. C. (1996), Biotechnol. Bioeng. 49(1), 15–19.

    Article  CAS  Google Scholar 

  4. Nienow, A. W., Hunt G., and Buckland, B. C. (1994), Biotechnol. Bioeng. 44, 1177–1185.

    Article  CAS  Google Scholar 

  5. Nienow, A. W., Weetman, R. J., Hunt, G., and Buckland, B. C. (1993) BHR Group Conference Series, publication no. 5 (3rd International Conference on Bioreactor and Bioprocess Fluid Dynamics), Nienow, A. W., ed., Mechanical Engineering Publications, London, pp. 505–519.

    Google Scholar 

  6. Junker, B. H., Stanik, M., Barna, C., Salmon, P., Paul, E., and Buckland, B. C. (1998), Bioprocess Eng. 18, 401–412.

    Article  CAS  Google Scholar 

  7. Junker, B. H., Stanik, M., Barna, C., Salmon, P., and Buckland, B. C. (1998), Bioprocess Eng. 19, 403–413.

    Article  CAS  Google Scholar 

  8. Saito, F., Nienow, A. W., Chatwin, S., and Moore, I. P. T. (1992), J. Chem. Eng. 25(3), 281–287.

    Article  CAS  Google Scholar 

  9. Pedersen, A. G. (1997), in Bioreactor and Bioprocess Fluid Dynamics (BHR Group Conference Series, publication no. 25), Nienow, A. W., ed., Mechanical Engineering Publications Limited, London, pp. 263–275.

    Google Scholar 

  10. Galindo, E. and Nienow, A. W. (1993), Chem. Eng. Technol. 16, 102–108.

    Article  CAS  Google Scholar 

  11. Serrano-Carreon, L. and Galindo, E. (1997), Recent Prog. Genie Procedes 11(51), 161–168.

    CAS  Google Scholar 

  12. Cooke, M., Middleton, J. C., and Bush, J. R. (1988), Proceedings of 2nd Bioreactor Conference, Cambridge, UK BHRA, pp. 37–64.

    Google Scholar 

  13. Myers, K. J., Fasano, J. B., and Bakker, A. (1994), ICHEME Symposium Series 136, 65–72.

    CAS  Google Scholar 

  14. Whitton, M., Cropper, S., and Ozcanj-Taskin, N. G. (1997), in Bioreactor and Bioprocess Fluid Dynamics (BHR Group Conference Series, publication no. 25), Nienow, A. W., ed., Mechanical Engineering Publications Limited, London, pp. 277–294.

    Google Scholar 

  15. Amanullah, A., Serrano-Carreon, L., Castro, B., Galindo, E., and Nienow, A. W. (1998), Biotechnol. Bioeng. 57(1), 95–108.

    Article  CAS  Google Scholar 

  16. Bakker, A., Smith, J. M., and Myers, K. (1994), Chem. Eng. 101(12), 98–104.

    CAS  Google Scholar 

  17. Dronawat, S. N., Svihla, C. K., and Hanley, T. R. (1997), Appl. Biochem. Biotechnol. 63–65, 363–373.

    Article  Google Scholar 

  18. Nauman, E. B., Etchelles, A. W., and Tatterson, G. B. (1988), Chem. Eng. Prog. 84(5), 58–69.

    Google Scholar 

  19. Junker, B., Mann, Z., Gailliot, P., Byrne, K., and Wilson, J. (1998), Biotechnol. Bioeng. 60(5), 580–588.

    Article  CAS  Google Scholar 

  20. Bills, G. F., Platas, G., Pelaez, F., and Masurekar, P. (1999), Mycol. Res. 103(2), 179–192.

    Article  CAS  Google Scholar 

  21. Gaspar, A., Strodioat, L., and Thonart, P. H. (1998), Appl. Biochem. Biotechnol. 70–72, 535–545.

    Google Scholar 

  22. Schugerl, K. (1982), Int. Chem. Eng. 22(4), 591–610.

    Google Scholar 

  23. Charles, M. (1978), Adv. Biochem. Eng. 8, 1–62.

    CAS  Google Scholar 

  24. Nienow, A. W. (1990), TIBTECH 8(8), 224–233.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Bioprocess Research and Development, Merck Research Laboratories, Building 810-127, PO Box 2000, 07065, Rahway, NJ

    Beth H. Junker, Zorina Mann & George Hunt

Authors
  1. Beth H. Junker
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  2. Zorina Mann
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  3. George Hunt
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Correspondence to Beth H. Junker.

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Junker, B.H., Mann, Z. & Hunt, G. Retrofit of CD-6 (smith) impeller in fermentation vessels. Appl Biochem Biotechnol 89, 67–83 (2000). https://doi.org/10.1385/ABAB:89:1:67

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  • DOI: https://doi.org/10.1385/ABAB:89:1:67

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