Skip to main content
SpringerLink
Log in

Comparison of various optimization approaches for fed-batch ethanol production

  • Published:
Applied Biochemistry and Biotechnology Aims and scope Submit manuscript

Abstract

Various optimization techniques have been proposed to optimize the feedrate profile to maximize ethanol production. Among them are the differential algebraic system (DAS) approach, Kelly transformation approach, singular control approach, and on-off control approach. These methods are compared and it is shown that the DAS approach and Kelly transformation method are equivalent. A nonsingular transformation approach is presented. The performance obtained with the nonsingular approach is the same as that obtained with the singular approach and better than those obtained with the DAS and on-off control approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

F :

substrate feed rate (h−1)

H :

Hamiltonian

K P , K′ P , K S , K′ S :

Monod constants

P :

product concentration (g/L)

PI :

performance index

S :

substrate concentration (g/L)

S f :

substrate feed concentration (g/L)

V :

reactor volume (L)

X :

cell mass (g/L)

X 3 :

reactor volume (L)

Y XS :

cell yield (g cell/g substrate)

α:

Lagrangian multiplier

λ:

adjoint vector

μ:

specific growth rate (h−1)

π:

specific production rate (h−1)

σ:

substrate consumption rate (h−1)

References

  1. Cazzador, L. (1988), Biotechnol. Bioeng. 31, 670–676.

    Article  CAS  Google Scholar 

  2. Kishimoto, M., Sawano, T., Yoshida, T., and Taguchi, H. (1982), Proc. Ist. IFAC Workshop on Modeling and Control of Biotechnical Processes. Pergamon, Helsinki, pp. 161–168.

    Google Scholar 

  3. Menawat, A., Mutharasan, R., and Coughanowr, D. R. (1987), AIChE J. 33, 776–783.

    Article  CAS  Google Scholar 

  4. Park, S. and Ramirez, W. F. (1988), AIChE J. 34, 1550–1558.

    Article  CAS  Google Scholar 

  5. Hong, J. (1986), Biotechnol. Bioeng. 28, 1421–1431.

    Article  CAS  Google Scholar 

  6. Modak, J. M., Lim, H. C., and Tayeb, Y. J. (1986), Biotechnol. Bioeng. 28, 1396–1407.

    Article  CAS  Google Scholar 

  7. Lim, H. C., Tayeb, Y. J., Modak, J. M., and Bonte, P. (1986), Biotechnol. Bioeng. 28, 1408–1420.

    Article  CAS  Google Scholar 

  8. Guthke, R. and Knorre, W. A. (1981), Biotechnol. Bioeng. 23, 2771.

    Article  CAS  Google Scholar 

  9. San, K. Y. and Stephanopoulos, G. (1984), Biotechnol. Bioeng. 26, 1261–1264.

    Article  Google Scholar 

  10. Modak, J. M. and Lim, H. C. (1989), Biotechnol. Bioeng. 33, 11–15.

    Article  CAS  Google Scholar 

  11. Fu, P. C. and Barford, J. P. (1993), J. Proc. Cont. 3, 211–218.

    Article  CAS  Google Scholar 

  12. Kelly, J. H. (1965), SIAM J. Control 2, 234–240.

    Article  Google Scholar 

  13. Chen, C.-T. and Hwang, C. (1990), Ind. Eng. Chem. Res. 29, 1869–1875.

    Article  CAS  Google Scholar 

  14. Aiba, S., Humphrey, A. E., and Mills, N. F. (1973), Biochemical Engineering, University of Tokyo Press, Tokyo.

    Google Scholar 

  15. Lee, J. H., Hong, J., and Lim, H. C. (1997), Biotechnol. Bioeng. 56, 697–705.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bioprocess Technology Research Division, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, 305-600, Yusong, Taejon, Korea

    Jung-Heon Lee

Authors
  1. Jung-Heon Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, JH. Comparison of various optimization approaches for fed-batch ethanol production. Appl Biochem Biotechnol 81, 91–106 (1999). https://doi.org/10.1385/ABAB:81:2:91

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/ABAB:81:2:91

Index Entries

Search

Navigation