The effect of nutrients on L(+)-lactic acid production from glucose was investigated using Rhizopus oryzae ATCC 523 11. From the shake-flask experiments, the optimal medium composition was defined for improved lactic-acid production. In order to enhance lactic-acid production rate and product yield, controlled aeration in a bubble column was conducted under optimal conditions. Results showed a maximum lactic-acid production rate of 2.58 g/L/h was obtained with an initial glucose concentration of 94 g/L. Finallactic-acid concentration of 83 g/L was achieved after 32 h of fermentation with a weight of 0.88 glactic acid/g glucose consumed.
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Zhou, Y., Domínguez, J.M., Cao, N. et al. Optimization of L-Lactic acid production from glucose by Rhizopus oryzae ATCC 52311. Appl Biochem Biotechnol 78, 401–407 (1999). https://doi.org/10.1385/ABAB:78:1-3:401
- Bubble column
- lactic acid
- Rhizopus oryzae