Stem Cell Reviews

, Volume 1, Issue 1, pp 45–51 | Cite as

Stem cell plasticity

A rare cell, not a rare event
  • Yoon-Young Jang
  • Saul J. SharkisEmail author


Purification to homogeneity for a rare stem cell (SC) population by both function and phenotype is a prerequisite to determine if SCs can change their fate (plasticity). Since cell fate determination has been suggested by both external environmental cues and intrinsic gene regulation, plasticity should be studied using both influences. Different frequencies of marrow SC plasticity may be attributed to either different isolation technologies or different developmental stage SCs with more or less multipotentiality. Tissue-specific SCs may reside in marrow, or alternatively, primitive marrow SC may respond directly to regenerative signals by migration to injury sites and repairing the damaged tissue. It is important to dissect the relationship between primitive/tissue-specific SCs and regenerative signals.

Index Entries

Plasticity marrow stem cell tissue-specific stem cell regenerative signals cell fate change 


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Copyright information

© Humana Press Inc. 2005

Authors and Affiliations

  1. 1.Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsJohns Hopkins University School of MedicineBaltimoreUSA

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