NeuroMolecular Medicine

, Volume 5, Issue 1, pp 85–108

Genes associated with addiction

Alcoholism, opiate, and cocaine addiction
  • Mary Jeanne Kreek
  • David A. Nielsen
  • K. Steven LaForge
Article

Abstract

Drug addiction is a complex disorder that has a large spectrum of causes. Vulnerability to addiction has been shown in twin studies to have a robust genetic component. This genetic basis for addiction has general and specific components for each drug abused. Although many genes have been implicated in drug addiction, only a handful have either been replicated to have an association or to have an identified functional mechanism related to specific effects of abused drugs. A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article.

Index Entries

Addiction alcohol cocaine genetics genotype opiate physiogenetics physiogenomics polymorphism single nucleotide polymorphism 

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Copyright information

© Humana Press Inc 2004

Authors and Affiliations

  • Mary Jeanne Kreek
    • 1
  • David A. Nielsen
    • 1
  • K. Steven LaForge
    • 1
  1. 1.Laboratory of the Biology of Addictive DiseasesThe Rockefeller UniversityNew York

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